Patents by Inventor Samuel E. Driver

Samuel E. Driver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetic inhibition by double-stranded RNA
    Patent number: 10358653
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: July 23, 2019
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic Inhibition by Double-Stranded RNA
    Publication number: 20160208280
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: January 22, 2016
    Publication date: July 21, 2016
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig c. Mello
  • Genetic inhibition by double-stranded RNA
    Patent number: 9102939
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: August 11, 2015
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic Inhibition by Double-Stranded RNA
    Publication number: 20140350083
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 27, 2014
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition by double-stranded RNA
    Patent number: 8580754
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: November 12, 2013
    Assignees: Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Z. Fire, Stephen A. Kostas, Mary K. Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • GENETIC INHIBITION BY DOUBLE-STRANDED RNA
    Publication number: 20130230492
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: October 8, 2012
    Publication date: September 5, 2013
    Applicants: THE UNIVERSITY OF MASSACHUSETTS, CARNEGIE INSTITUTION OF WASHINGTON
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic Inhibition by Double-Stranded RNA
    Publication number: 20130029425
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 31, 2013
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition of double-stranded RNA
    Patent number: 8283329
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 9, 2012
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Z. Fire, Stephen A. Kostas, Mary K. Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition by double-stranded RNA
    Patent number: 7622633
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: November 24, 2009
    Assignee: Carnegie Institution of Washington
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition by double-stranded RNA
    Patent number: 7560438
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: July 14, 2009
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition by double-stranded RNA
    Patent number: 7538095
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: May 26, 2009
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic Inhibition of double-stranded RNA
    Publication number: 20080248576
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: September 28, 2007
    Publication date: October 9, 2008
    Applicants: Carnegie Institution of Washington, the, University of Massachusetts, the
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Transplacental delivery of oligonucleotides
    Patent number: 6576218
    Abstract: This invention provides synthetic oligonucleotides that are useful for transplacental delivery, the oligonucleotides being DNA or RNA or both, preferably between 12-35 nucleotides in length, having a stabilized and charged backbone and at least one chemically modified base or sugar moiety, wherein the modified base or sugar moiety facilitates transplacental delivery.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: June 10, 2003
    Assignee: Quantitative Informational Knockout Technology
    Inventors: Peter C. Roberts, Samuel E. Driver
  • Genetic inhibition by double-stranded RNA
    Publication number: 20030056235
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: October 30, 2002
    Publication date: March 20, 2003
    Applicant: THE CARNEGIE INSTITUTION OF WASHINGTON
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition by double-stranded RNA
    Publication number: 20030055020
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: October 30, 2002
    Publication date: March 20, 2003
    Applicant: The Carnegie Institution of Washington
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition by double-stranded RNA
    Publication number: 20030051263
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Application
    Filed: October 30, 2002
    Publication date: March 13, 2003
    Applicant: The Carnegie Institution of Washington
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition by double-stranded RNA
    Patent number: 6506559
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: January 14, 2003
    Assignee: Carnegie Institute of Washington
    Inventors: Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Transplacental delivery of oligonucleotides
    Patent number: 6306831
    Abstract: This invention provides synthetic oligonucleotides that are useful for transplacental delivery, the oligonucleotides being DNA or RNA or both, preferably between 12-35 nucleotides in length, having a stabilized and charged backbone and at least one chemically modified base or sugar moiety, wherein the modified base or sugar moiety facilitates transplacental delivery.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: October 23, 2001
    Assignee: QIK Technologies, Inc.
    Inventors: Peter C. Roberts, Samuel E. Driver