Patents by Inventor Samuel E. Gandy

Samuel E. Gandy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation
    Patent number: 5385915
    Abstract: A method of regulating phosphorylation of proteins involved in controlling processing or function of key proteins found in intracellular neurofibrillary tangles and extracellular amyloid plaques associated with Alzheimer disease comprising introducing an effective amount of a kinase modulator or phosphatase modulator, the modulator capable of increasing or decreasing the rate of proteolytic processing, or modulating the function, of said key proteins.
    Type: Grant
    Filed: June 7, 1993
    Date of Patent: January 31, 1995
    Assignee: The Rockefeller University
    Inventors: Joseph D. Buxbaum, Samuel E. Gandy, Paul Greengard
  • Method of screening for modulators of amyloid formation
    Patent number: 5348963
    Abstract: Agents which modulate or affect the intracellular trafficking and processing of proteins in the mammalian cell can be utilized to affect the trafficking and processing of APP, thereby inhibiting production of Alzheimer type amyloidosis. Particularly useful agents are chloroquine and its related derivatives such as primaquine.
    Type: Grant
    Filed: May 26, 1993
    Date of Patent: September 20, 1994
    Assignee: The Rockefeller University
    Inventors: Samuel E. Gandy, Gregg L. Caporaso, Paul Greengard
  • Treatment of amyloidosis associated with Alzheimer disease
    Patent number: 5242932
    Abstract: Agents which modulate or affect the intracellular trafficking and processing of proteins in the mammalian cell can be utilized to affect the trafficking and processing of APP, thereby inhibiting production of Alzheimer type amyloidosis. Particularly useful agents are chloroquine and its related derivatives such as primaquine.
    Type: Grant
    Filed: December 17, 1991
    Date of Patent: September 7, 1993
    Assignee: The Rockefeller University
    Inventors: Samuel E. Gandy, Gregg L. Caporaso, Paul Greengard
  • Use of phosphoprotein patterns for diagnosis of neurological and psychiatric disorders
    Patent number: 4874694
    Abstract: A diagnostic method for neurological and psychiatric disorders utilizes the cerebrospinal fluid incubated in the presence of 32-P labelled ATP and an appropriate protein kinase. After termination of the reaction, a sample is applied to gels for electrophoresis. Subsequent autoradiography results in a disease-specific protein pattern that can be used for diagnosis of disorders such as Alzheimer disease, Huntington disease, Parkinson disease, dystonia ataxia, schizophrenia, epilepsy brain tumors, brain irradiation, head trauma, and acute and chronic encephalitic and vascular disease.
    Type: Grant
    Filed: April 7, 1987
    Date of Patent: October 17, 1989
    Assignee: The Rockefeller University
    Inventors: Samuel E. Gandy, Paul Greengard