Abstract: Utilizing reference/identification (ID) linking in extensible markup language (XML) wrapper code generation in a data processing system. A code generator receives a type document and reference/ID constraints document and accesses the reference/ID constraints document to translate between XML structures and object structures.

Abstract: Utilizing reference/identification (ID) linking in extensible markup language (XML) wrapper code generation in a data processing system. A code generator receives a type document and reference/ID constraints document and accesses the reference/ID constraints document to translate between XML structures and object structures.

Abstract: The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.

Abstract: Utilizing reference/identification (ID) linking in extensible markup language (XML) wrapper code generation in a data processing system. A code generator receives a type document and reference/ID constraints document and accesses the reference/ID constraints document to translate between XML structures and object structures.

Abstract: Embodiments are directed to a method, medium, and system for generating a distribution attribution value to analyze distribution of telecommunications services. The method including compiling values for at least three variable elements associated with the distribution of telecommunication services. A first total value being defined as a product of first element values associated with the at least three variable elements. A second total value being defined as a product of second element values associated with the at least three variable elements. The method also including generating an attribution value representing an amount of influence at least one of the at least three variable elements has on a difference between the first and the second total values. The attribution value being calculated using the first and second total values. Also, the attribution value being adapted to at least one of verify and adjust the distribution of telecommunication services.

Abstract: The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.

Abstract: The present invention relates to microarray polymeric barriers designed to control the release rate of therapeutic agents. By varying the thickness of the coating or affecting, physically and/or chemically, the constituents of the barrier composition, the release profile of the underlying therapeutic agent can be modified and controlled.

Abstract: The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.

Abstract: Embodiments are directed to a method, medium, and system for generating a distribution attribution value to analyze distribution of telecommunications services. The method including compiling values for at least three variable elements associated with the distribution of telecommunication services. A first total value being defined as a product of first element values associated with the at least three variable elements. A second total value being defined as a product of second element values associated with the at least three variable elements. The method also including generating an attribution value representing an amount of influence at least one of the at least three variable elements has on a difference between the first and the second total values. The attribution value being calculated using the first and second total values. Also, the attribution value being adapted to at least one of verify and adjust the distribution of telecommunication services.

Abstract: Utilizing reference/identification (ID) linking in extensible markup language (XML) wrapper code generation in a data processing system. A code generator receives a type document and reference/ID constraints document and accesses the reference/ID constraints document to translate between XML structures and object structures.

Abstract: The present invention relates to the direct delivery of therapeutic to a target tissue. In one embodiment a method for direct injection of plug forming material into a body tissue is provided. The method may comprise providing a catheter including a injection tube having a first channel, a second channel and a piercing tip. The first and second channels can be in fluid communication with a pressure source and a plug forming material. The injection tube may be slidably positioned in a pressure apron and moved from a first position to a second position so that the piercing tip extends beyond the tissue-mating surface in the second position to deliver the plug forming material.

Abstract: A medical device for: delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.

Abstract: Embodiments of the present invention permit the specification and servicing of aggregations of content constituent parts that derive from electronic documents. An incorporated content constituent part may correspond to any constituent part of any accessible document. In various embodiments, information derived from the intended layouts of source documents is employed to construct specifications of the constituent parts. The specifications may include search conditions. Graphic methods may be employed to construct the specification. Embodiments of the present invention enable content aggregations to appear in display presentations whose layouts may be adaptive to varying degrees. In various embodiments, flexible content-shifting methods are employed for display presentations of content aggregations. Resultantly, the display of content aggregations on mobile and other devices may be effectuated without wasting download bandwidth and display screen real estate.

Abstract: This invention provides a high-solids therapeutic composition for coating a medical device comprising: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the composition is in a singular stable phase. Also provided is a mold-cast medical device, said medical device comprising a cured mixture of: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the mixture forms a high-solids device. Further provided is an injectable polymer comprising: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the polymer is in a singular stable phase.

Abstract: Injection devices are provided, which reduce potential outflow of therapeutic agents from an injection site. Devices are provided having at least a first lumen containing one or more therapeutic agents and a second lumen containing a second material for injection into tissue. Other devices are provided having an inner lumen with an injection needle to inject a therapeutic agent and an outer lumen that provides a vacuum seal between the injection needle and the needle track. Further provided are methods of delivering a therapeutic agent to tissue.

Abstract: The present invention regards the delivery of therapeutic at a target site. Systems that employ the present invention may employ a medical device sized to be inserted into a target site, a driving layer covering at least a portion of an accessible surface of the medical device, and a therapeutic interfaced with at least a portion of the driving layer. In this system, the driving layer may have a material characteristic that serves to release the therapeutic from the medical device when the medical device is at the target site. Other systems that employ the invention may also have properties that include having a driving layer with a higher solubility than the therapeutic at the target site, a medical device that is hydrophobic while the therapeutic is hydrophilic, and a coating covering at least a portion of the therapeutic.

Abstract: Methods and apparatuses for generating rendering layout specifications for content items to be rendered, using display containers, and/or rendering the content items using the generated rendering layout specification are disclosed. In various embodiments, the generating of a rendering layout specification may include one or more of selecting a display container for a content item, selecting a content item for a display container, and selecting a display container for a display container.

Abstract: Methods and apparatus for coating at least a portion of the surface of medical devices using an injection coating device are disclosed. In one embodiment, the invention includes a coating method wherein an orifice of the injection coating device is placed adjacent a vertically positioned medical device, coating material is ejected from the orifice onto the medical device, and the coating material gravitationally flows downward coating the medical device. In another embodiment, an orifice of an injection coating device is positioned adjacent a horizontally positioned medical device to gravitationally flow and deposit coating material onto the medical device. These methods may be used to apply one or more coating materials, simultaneously or in sequence. In another embodiment, multiple injection coating devices may be utilized. In certain embodiments of the invention, the coating materials include therapeutic or biologically active agents.

Abstract: A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.

Abstract: A device, system, and method for direct delivery of a therapeutic to a target site that utilizes the non-Newtonian characteristics of shear thinning and shear thickening to allow easy passage of a therapeutic through a delivery lumen yet facilitate retention of the therapeutic in the target site. The device, system, and method includes increasing the shear rate or shear stress of a non-Newtonian fluid having therapeutic properties thereby increasing or decreasing the viscosity of the non-Newtonian fluid.