Abstract: The invention provides methods of using low coverage sequencing to assess the relative fraction of tumor versus normal DNA in a sample, and to assess copy number alterations present in the sample.

Abstract: The present invention provides methods of predicting a patient's response to immunotherapy, in particular checkpoint blockade therapy, and provides for treatments. Disclosed herein are novel combinations of factors identified in tumors used to predict response and provide for treatments. Also, disclosed are methods of treatment that can shift a tumor to a responder phenotype.

Abstract: A kit for attenuation of noise includes a noise source audio transducer, two ear pieces, and a control unit. The two ear pieces have respective resilient bodies that engage outer portions of ear canals of respective ears of a user while respective in-ear transducers of the two ear pieces are respectively positioned in inner portions of the ear canals. The respective in-ear transducers detect discrepancies (e.g., incomplete superpositioning) between the noise and the anti-noise. The respective in-ear transducers optionally detect respective secondary path effects in the ear canals. The noise source audio transducer detects noise generated by a noise source (e.g., snoring noise). The control unit configures an adaptive filter based at least in part on an error signal, and optionally based in part on secondary path effects. The control unit generates signals representative of anti-noise. The two ear pieces produce the anti-noise responsive to the signals.

Abstract: A kit for attenuation of noise includes a noise source audio transducer, two ear pieces, and a control unit. The two ear pieces have respective resilient bodies that engage outer portions of ear canals of respective ears of a user while respective in-ear transducers of the two ear pieces are respectively positioned in inner portions of the ear canals. The respective in-ear transducers detect discrepancies (e.g., incomplete superpositioning) between the noise and the anti-noise. The respective in-ear transducers optionally detect respective secondary path effects in the ear canals. The noise source audio transducer detects noise generated by a noise source (e.g., snoring noise). The control unit configures an adaptive filter based at least in part on an error signal, and optionally based in part on secondary path effects. The control unit generates signals representative of anti-noise. The two ear pieces produce the anti-noise responsive to the signals.

Abstract: The invention provides methods of using low coverage sequencing to assess the relative fraction of tumor versus normal DNA in a sample, and to assess copy number alterations present in the sample.

Abstract: A kit for attenuation of noise includes a noise source audio transducer, two ear pieces, and a control unit. The two ear pieces have respective resilient bodies that engage outer portions of ear canals of respective ears of a user while respective in-ear transducers of the two ear pieces are respectively positioned in inner portions of the ear canals. The respective in-ear transducers detect discrepancies (e.g., incomplete superpositioning) between the noise and the anti-noise. The respective in-ear transducers optionally detect respective secondary path effects in the ear canals. The noise source audio transducer detects noise generated by a noise source (e.g., snoring noise). The control unit configures an adaptive filter based at least in part on an error signal, and optionally based in part on secondary path effects. The control unit generates signals representative of anti-noise. The two ear pieces produce the anti-noise responsive to the signals.

Abstract: A method and system for dynamically manipulating values associated with graphical elements displayed within a graphic interface of a data-processing system. Initially a pointer element associated with a pointing device is displayed within the graphic interface, such that the pointer element is capable of movement in multiple directions in response to movement of the pointing device. A trackslide element and a moveable slider are displayed within the graphic interface. The moveable slider permits users to dynamically decrease or increase values associated with the trackslide element, such that the moveable slider is constrained to move only in a first direction along the trackslide element. The pointer element is then graphically attached to the moveable slider.

Abstract: This invention relates to the photographic reproduction of color or monochromatic still pictures as displayed on the face of a cathode-ray tube (CRT). The invention combines the arts of television and photographics to make possible the retention of still color photographs (slides) from a television screen. A "frame grabber" is used to stop the motion of a television image and hold it while a simple color photographic process captures it.