Patents by Inventor Samuel G. Franklin

Samuel G. Franklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acetate-free purification of plasmid DNA on hydroxyapatite
    Patent number: 6406892
    Abstract: Plasmid DNA is purified from a cell lysate by acidifying the lysate with a combination of a mineral acid and an inorganic salt in place of the commonly used acetate buffer, allowing chromosomal DNA and other impurities to precipitate out and recovering the supernatant, and applying the supernatant directly to a hydroxyapatite chromatographic separation medium. The use of the mineral acid and organic salt avoids the degradation of the hydroxyapatite that frequently accompanies repeated use with acetate and related compounds.
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: June 18, 2002
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Cheryl S. Aberin, Samuel G. Franklin