Patents by Inventor Samuel I. Miller

Samuel I. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-substituted-2-imino-thiazolidinone compounds and their use as inhibitors of bacterial infection
    Patent number: 8252940
    Abstract: A method for inhibiting Gram-negative bacterial pathogenesis, a method of screening for compounds that inhibit type III secretion in Gram-negative bacteria, and compounds that inhibit type III secretion in Gram-negative bacteria.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: August 28, 2012
    Assignee: University of Washington
    Inventors: Heather B. Felise, Samuel I. Miller, Toni Kline
  • 5-SUBSTITUTED-2-IMINO-THIAZOLIDINONE COMPOUNDS AND THEIR USE AS INHIBITORS OF BACTERIAL INFECTION
    Publication number: 20110039849
    Abstract: A method for inhibiting Gram-negative bacterial pathogenesis, a method of screening for compounds that inhibit type III secretion in Gram-negative bacteria, and compounds that inhibit type III secretion in Gram-negative bacteria.
    Type: Application
    Filed: August 16, 2010
    Publication date: February 17, 2011
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Heather B. Felise, Samuel I. Miller, Toni Kline
  • Salmonella secreted proteins and uses thereof
    Patent number: 6861247
    Abstract: Substantially pure Salmonella secreted proteins (Ssp), the sercetion of which is dependent upon the expession of PrgH; methods of diagnosing Salmonella infection; and live attenuated vaccine strains in which Ssp secretion is decreased.
    Type: Grant
    Filed: November 14, 1996
    Date of Patent: March 1, 2005
    Assignee: The General Hospital Corporation
    Inventor: Samuel I. Miller
  • Salmonella virulence genes
    Patent number: 6010901
    Abstract: A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 4, 2000
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Samuel I. Miller, III, John J. Mekalanos
  • Salmonella vaccines
    Patent number: 5843426
    Abstract: The invention features a Salmonella cell the virulence of which is attenuated by a deletion of a portion of the PhoQ gene and Salmonella cells having a deletion of the PhoQ gene and a deletion of the PhoP gene. The invention also features vaccines comprising such bacteria.
    Type: Grant
    Filed: December 1, 1995
    Date of Patent: December 1, 1998
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Samuel I. Miller, John J. Mekalanos
  • Salmonella vectors encoding truncated pag fusion protein, method of making, and uses thereof
    Patent number: 5733760
    Abstract: A modified Salmonella, wherein the wild type pag gene such as pagC has been replaced by a gene encoding a truncated pag gene such as pagC gene fused to a heterologous DNA segment, is disclosed. This modification significantly attenuates the virulence of the Salmonella. In addition, immune reaction to the portion of the fusion protein encoded by the heterologous gene can be generated. Uses of the vector, including its use in a drug screen are also disclosed.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: March 31, 1998
    Assignees: Virus Research Institute, The General Hospital Corporation
    Inventors: Yichen Lu, Samuel I. Miller, Kevin Killeen
  • Salmonella virulence genes
    Patent number: 5731196
    Abstract: A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: March 24, 1998
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Samuel I. Miller, III, John J. Mekalanos
  • Salmonella vaccines
    Patent number: 5695983
    Abstract: A bacterial cell the virulence of which is attentuated by a first mutation in a PhoP regulon and a second mutation in an aromatic amino acid synthetic gene and bacterial cells the virulence of which is attenuated by a mutation in one or more PhoP-activated genes or one or more PhoP-repressed genes.
    Type: Grant
    Filed: July 6, 1994
    Date of Patent: December 9, 1997
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Samuel I. Miller, John J. Mekalanos
  • Salmonella virulence genes
    Patent number: 5674724
    Abstract: A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Samuel I. Miller, III, John J. Mekalanos
  • Salmonella virulence genes
    Patent number: 5674736
    Abstract: A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Samuel I. Miller, III, John J. Mekalanos
  • Salmonella virulence genes
    Patent number: 5599537
    Abstract: A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated.
    Type: Grant
    Filed: July 9, 1993
    Date of Patent: February 4, 1997
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Samuel I. Miller, III, John J. Mekalanos
  • Antibiotic cryptdin peptides and methods of their use
    Patent number: 5422424
    Abstract: The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence as follows:X.sub.1 -C-X.sub.2 -C-R-X.sub.3 -C-X.sub.4 -E-X.sub.5 -G-X.sub.6 -C-X.sub.7 -C-C-X.sub.8wherein X.sub.1 is 3-6 amino acids; X.sub.2 is one amino acid; X.sub.3 is 2 or 3 amino acids; X.sub.4 is three amino acids; X.sub.5 is three amino acids; X.sub.6 is one amino acid; X.sub.7 is 6 to 10 amino acids; and X.sub.8 is 0 to 7 amino acids.The invention further provides substantially purified cryptdin peptides having a consensus amino acid sequence as follows:X.sub.1 -L-X.sub.2 -C-Y-C-R-X.sub.3 -C-K-X.sub.4 -E-R-X.sub.5 -G-T-C-X.sub.6 -C-C-X.sub.7wherein X.sub.1 is one to four amino acids; X.sub.2 is one amino acid; X.sub.3 is three amino acids; X.sub.4 is two amino acids; X.sub.5 is two amino acids; and X.sub.6 is six to nine amino acids; and X.sub.7 is zero to seven amino acids.
    Type: Grant
    Filed: August 14, 1992
    Date of Patent: June 6, 1995
    Assignees: The Regents of the University of California, The Shriner's Hospital for Crippled Children, The General Hospital Corporation
    Inventors: Michael E. Selsted, Andre J. Ouellette, Samuel I. Miller