Patents by Inventor Samuel I. Stupp

Samuel I. Stupp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COVALENT AND SUPRAMOLECULAR POLYMERS
    Publication number: 20170088706
    Abstract: Provided herein are compositions comprising covalent and supramolecular polymers, and methods of preparation and use thereof.
    Type: Application
    Filed: September 28, 2016
    Publication date: March 30, 2017
    Inventors: Zhilin Yu, Samuel I. Stupp
  • Modular Supramolecular Approach for Co-Crystallization of Donors and Acceptors into Ordered Networks
    Publication number: 20170053721
    Abstract: Organic charge-transfer (CT) co-crystals in a mixed stack system are disclosed, wherein a donor molecule (D) and an acceptor molecule (A) occupy alternating positions (DADADA) along the CT axis. A platform is provided which amplifies the molecular recognition of donors and acceptors and produces co-crystals at ambient conditions, wherein the platform comprises (i) a molecular design of the first constituent (?-complement), (ii) a molecular design of the second compound (?-complement), and (iii) a solvent system that promotes co-crystallization.
    Type: Application
    Filed: August 31, 2016
    Publication date: February 23, 2017
    Inventors: Samuel I. Stupp, J. Fraser Stoddart, Alexander K. Shveyd, Alok S. Tayi, Chi-Hau Sue, Ashwin Narayanan
  • Anti-angiogenic molecules, nanostructures and uses thereof
    Patent number: 9556232
    Abstract: The disclosure is generally directed toward the design and synthesis of peptide amphiphile (PA) molecules that comprises a peptide configured to inhibit angiogenesis. The peptide amphiphile comprises a hydrophobic tail, peptide sequence capable of beta-sheet formation; and a peptide, wherein the peptide is configured to inhibit angiogenesis. Optionally the PA further comprises a flexible linker between the peptide sequence capable of beta-sheet formation and the peptides. Further this disclosure is directed to nanostructures comprising peptide amphiphiles configured to inhibit angiogenesis.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: January 31, 2017
    Assignee: Northwestern University
    Inventors: Runye H. Zha, Ming Zhang, Samuel I. Stupp
  • PEPTIDE AMPHIPHILE BIOMATERIALS FOR NERVE REPAIR
    Publication number: 20170021056
    Abstract: Provided herein are compositions comprising aligned peptide amphiphile biomaterials, methods of generating such alignment, and their use in nerve repair applications. In particular, peptide amphiphile nanofibers are aligned using a screen extrusion method, and find use in the repair of peripheral nerve injuries.
    Type: Application
    Filed: July 20, 2016
    Publication date: January 26, 2017
    Inventors: Samuel I. Stupp, Mark T. McClendon, Reza Jarrahy, Akishige Hokugo
  • Supramolecular Networks with Electron Transfer in Two Dimensions
    Publication number: 20160372229
    Abstract: Organic charge-transfer (CT) co-crystals in a crossed stack system are disclosed. The co-crystals exhibit bidirectional charge transfer interactions where one donor molecule shares electrons with two different acceptors, one acceptor face-to-face and the other edge-to-face. The assembly and charge transfer interaction results in a pleochroic material whereby the optical absorption continuously changes depending on the polarization angle of incident light.
    Type: Application
    Filed: August 30, 2016
    Publication date: December 22, 2016
    Inventors: Samuel I. Stupp, J. Fraser Stoddart, Alexander K. Shveyd, Alok S. Tayi, Chi-Hau Sue, Ashwin Narayanan
  • Targeted therapy for the prevention of restenosis in the cardiovascular system
    Patent number: 9517275
    Abstract: Provided herein are compositions and methods for targeted drug delivery to prevent restenosis in the cardiovascular system. In particular, provided herein are nanoscale delivery vehicles for drugs that prevent proliferation and neointimal hyperplasia.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: December 13, 2016
    Assignee: Northwestern University
    Inventors: Melina R. Kibbe, Samuel I. Stupp, Tyson J. Moyer, Edward Moreira Bahnson
  • Aligned nanofibers and related methods of use
    Patent number: 9512404
    Abstract: The present invention relates to nanofibers. In particular, the present invention provides aligned nanofiber bundle assemblies. In some embodiments, the aligned nanofiber bundle assemblies are used for tissue regeneration, controlled growth of cells, and related methods (e.g., diagnostic methods, research methods, drug screening).
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: December 6, 2016
    Assignee: Northwestern University
    Inventors: Samuel I. Stupp, Shuming Zhang, Alvaro Mata, Megan A. Greenfield
  • Modular supramolecular approach for co-crystallization of donors and acceptors into ordered networks
    Patent number: 9449731
    Abstract: Organic charge-transfer (CT) co-crystals in a mixed stack system are disclosed, wherein a donor molecule (D) and an acceptor molecule (A) occupy alternating positions (DADADA) along the CT axis. A platform is provided which amplifies the molecular recognition of donors and acceptors and produces co-crystals at ambient conditions, wherein the platform comprises (i) a molecular design of the first constituent (?-complement), (ii) a molecular design of the second compound (?-complement), and (iii) a solvent system that promotes co-crystallization.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: September 20, 2016
    Assignee: Northwestern University
    Inventors: Samuel I. Stupp, J. Fraser Stoddart, Alex K. Shveyd, Alok S. Tayi, Andrew C. H. Sue, Ashwin Narayanan
  • Supramolecular networks with electron transfer in two dimensions
    Patent number: 9443636
    Abstract: Organic charge-transfer (CT) co-crystals in a crossed stack system are disclosed. The co-crystals exhibit bidirectional charge transfer interactions where one donor molecule shares electrons with two different acceptors, one acceptor face-to-face and the other edge-to-face. The assembly and charge transfer interaction results in a pleochroic material whereby the optical absorption continuously changes depending on the polarization angle of incident light.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: September 13, 2016
    Assignee: Northwestern University
    Inventors: Samuel I. Stupp, J. Fraser Stoddart, Alexander K. Shveyd, Alok S. Tayi, Chi-Hau Sue, Ashwin Narayanan
  • BMP-2-BINDING PEPTIDE AMPHIPHILE NANOFIBERS
    Publication number: 20160159869
    Abstract: Provided herein are peptide amphiphiles with binding affinity for the bone promoting growth factor BMP-2, and methods of use thereof. In particular nanofibers and gel scaffolds of BMP-2-binding peptide amphiphiles are provided.
    Type: Application
    Filed: December 9, 2015
    Publication date: June 9, 2016
    Inventors: Samuel I. Stupp, Erin L. Hsu, Wellington K. Hsu, Sungsoo Lee
  • ANTI-ANGIOGENIC MOLECULES, NANOSTRUCTURES AND USES THEREOF
    Publication number: 20160108088
    Abstract: The disclosure is generally directed toward the design and synthesis of peptide amphiphile (PA) molecules that comprises a peptide configured to inhibit angiogenesis. The peptide amphiphile comprises a hydrophobic tail, peptide sequence capable of beta-sheet formation; and a peptide, wherein the peptide is configured to inhibit angiogenesis. Optionally the PA further comprises a flexible linker between the peptide sequence capable of beta-sheet formation and the peptides. Further this disclosure is directed to nanostructures comprising peptide amphiphiles configured to inhibit angiogenesis.
    Type: Application
    Filed: October 27, 2015
    Publication date: April 21, 2016
    Inventors: Runye H. Zha, Ming Zhang, Samuel I. Stupp
  • Anti-angiogenic molecules, nanostructures and uses thereof
    Patent number: 9169294
    Abstract: The disclosure is generally directed toward the design and synthesis of peptide amphiphile (PA) molecules that comprises a peptide configured to inhibit angiogenesis. The peptide amphiphile comprises a hydrophobic tail, peptide sequence capable of beta-sheet formation; and a peptide, wherein the peptide is configured to inhibit angiogenesis. Optionally the PA further comprises a flexible linker between the peptide sequence capable of beta-sheet formation and the peptides. Further this disclosure is directed to nanostructures comprising peptide amphiphiles configured to inhibit angiogenesis.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 27, 2015
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Runye H. Zha, Ming Zhang, Samuel I. Stupp
  • TARGETED THERAPY FOR THE PREVENTION OF RESTENOSIS IN THE CARDIOVASCULAR SYSTEM
    Publication number: 20150151002
    Abstract: Provided herein are compositions and methods for targeted drug delivery to prevent restenosis in the cardiovascular system. In particular, provided herein are nanoscale delivery vehicles for drugs that prevent proliferation and neointimal hyperplasia.
    Type: Application
    Filed: September 30, 2014
    Publication date: June 4, 2015
    Inventors: Melina R. Kibbe, Samuel I. Stupp, Tyson J. Moyer
  • ELECTROSPINNING OF PEPTIDE AMPHIPHILES
    Publication number: 20150093574
    Abstract: Provided herein are methods for the manufacture of fibers from solution-phase peptide-based polymers by electrospinning, and compositions produced thereby. In particular embodiments, various embodiments provide electrospinning supramolecular fibers from low concentration peptide amphiphile filaments.
    Type: Application
    Filed: September 30, 2014
    Publication date: April 2, 2015
    Inventors: Alok S. Tayi, E. Thomas Pashuck, III, Samuel I. Stupp
  • SELF-ASSEMBLED NANOSTRUCTURES
    Publication number: 20150031127
    Abstract: The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nano structures.
    Type: Application
    Filed: August 31, 2012
    Publication date: January 29, 2015
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Samuel I. Stupp, Yves Ruff
  • ALIGNED NANOFIBERS AND RELATED METHODS OF USE
    Publication number: 20140315302
    Abstract: The present invention relates to nanofibers. In particular, the present invention provides aligned nanofiber bundle assemblies. In some embodiments, the aligned nanofiber bundle assemblies are used for tissue regeneration, controlled growth of cells, and related methods (e.g., diagnostic methods, research methods, drug screening).
    Type: Application
    Filed: July 8, 2014
    Publication date: October 23, 2014
    Inventors: Samuel I. Stupp, Shuming Zhang, Alvaro Mata, Megan A. Greenfield
  • Magnetic resonance imaging of self-assembled biomaterial scaffolds
    Patent number: 8834840
    Abstract: Compositions and/or mixtures comprising peptide amphiphile compounds comprising one or more contrast agents, as can be used in a range of magnetic resonance imaging applications.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: September 16, 2014
    Assignee: Northwestern University
    Inventors: Steve R. Bull, Thomas J. Meade, Samuel I. Stupp
  • ANTI-ANGIOGENIC MOLECULES, NANOSTRUCTURES AND USES THEREOF
    Publication number: 20140256635
    Abstract: The disclosure is generally directed toward the design and synthesis of peptide amphiphile (PA) molecules that comprises a peptide configured to inhibit angiogenesis. The peptide amphiphile comprises a hydrophobic tail, peptide sequence capable of beta-sheet formation; and a peptide, wherein the peptide is configured to inhibit angiogenesis. Optionally the PA further comprises a flexible linker between the peptide sequence capable of beta-sheet formation and the peptides. Further this disclosure is directed to nanostructures comprising peptide amphiphiles configured to inhibit angiogenesis.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 11, 2014
    Applicant: Northwestern University
    Inventors: Runye H. Zha, Ming Zhang, Samuel I. Stupp
  • Aligned nanofibers and related methods of use
    Patent number: 8772228
    Abstract: The present invention relates to nanofibers. In particular, the present invention provides aligned nanofiber bundle assemblies. In some embodiments, the aligned nanofiber bundle assemblies are used for tissue regeneration, controlled growth of cells, and related methods (e.g., diagnostic methods, research methods, drug screening).
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: July 8, 2014
    Assignee: Northwestern University
    Inventors: Samuel I. Stupp, Shuming Zhang, Alvaro Mata, Megan A Greenfield
  • Peptide amphiphiles and methods to electrostatically control bioactivity of the ikvav peptide epitope
    Patent number: 8748569
    Abstract: The present invention is directed to peptide amphiphile compounds, compositions and methods of use, wherein nanofiber bundling or epitope aggregation is inhibited. In certain embodiments, the peptide amphiphiles of the present invention have increased solubility and reduced nanofiber bundling. The molecules may be used in pharmaceutical applications, for example for in vivo administration to human patients, by increasing biological activity of the compositions toward neurite outgrowth and nerve regeneration.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: June 10, 2014
    Assignee: Northwestern University
    Inventors: Samuel I. Stupp, Joshua E. Goldberger, Eric J. Berns