Patents by Inventor Samuel J. Asirvatham

Samuel J. Asirvatham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220362545
    Abstract: This document describes implantable medical devices and methods of using such devices. The implantable medical devices include a cardiac lead sized for insertion in a cardiac cavity, the cardiac lead having a distal end and a proximal end and a lead body extending therebetween, a heat exchange module disposed at the distal end of the lead body, the heat exchange module comprising an enclosure having a first surface and a second surface, and one or more temperature sensors located within the enclosure.
    Type: Application
    Filed: May 12, 2022
    Publication date: November 17, 2022
    Inventors: Steve Maschino, Samuel J. Asirvatham, Jeffrey Rynbrandt, Charles Ritrivi, Paul A. Friedman, Richard Scott Sanders
  • Publication number: 20220346870
    Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.
    Type: Application
    Filed: July 18, 2022
    Publication date: November 3, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: David R. Holmes, JR., Samuel J. Asirvatham, Christopher V. DeSimone
  • Publication number: 20220296881
    Abstract: The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.
    Type: Application
    Filed: June 6, 2022
    Publication date: September 22, 2022
    Inventors: Samuel J. Asirvatham, Suraj Kapa, Sarah M. Gruba, Douglas D. Pagoria, James P. Rohl, Chance M. Witt, Ammar M. Killu, Niyada Naksuk
  • Patent number: 11426233
    Abstract: Embodiments of the present disclosure relate to treating diseased tissue with ablation therapy. In an embodiment, an apparatus comprises a catheter having an elongate body extending between a proximal end and a distal end. The apparatus further includes a balloon structure arranged proximal to the distal end of the catheter, wherein the balloon structure has a first portion with a first permeability and a second portion with a second permeability such that the first permeability is different than the second permeability. In addition, the apparatus includes a first electrode arranged on or within the balloon structure and configured to: transmit current through the first portion, receive current transmitted through the first portion or both.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: August 30, 2022
    Assignees: Cardiac Pacemakers, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Sarah M. Gruba, James P. Rohl, Samuel J. Asirvatham, Suraj Kapa, Chance M. Witt, Deepak Padmanabhan, Christopher V. DeSimone
  • Publication number: 20220249006
    Abstract: Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The ECG circuit board and the plurality of IC circuit boards share substantially a same circuit configuration and components. The ECG circuit board further processes the ECG signal using substantially a same path as each IC circuit board uses to process its corresponding IC signal.
    Type: Application
    Filed: April 13, 2022
    Publication date: August 11, 2022
    Applicants: BioSig Technologies, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Budimir S. DRAKULIC, Sina FAKHAR, Thomas G. FOXALL, Branislav VLAJINIC, Samuel J. ASIRVATHAM
  • Patent number: 11389642
    Abstract: The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: July 19, 2022
    Assignees: Cardiac Pacemakers, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Suraj Kapa, Sarah M. Gruba, Douglas D. Pagoria, James P. Rohl, Chance M. Witt, Ammar M. Killu, Niyada Naksuk
  • Publication number: 20220218289
    Abstract: Apparatuses and methods are provided to predict or diagnose an ischemic event, such as a stroke or a transient ischemic attack (TIA). A machine-learning model such as a neural network is generated that allows for recognition of an ECG consistent with an ischemic event. A system is trained and used to process a recording of ECG data from a patient to generate a prediction indicating a likelihood that the patient will experience a stroke. In other examples, a system is trained and used to process a recording of ECG data from a patient and detect an ischemic event for the patient who did not appear to have such an ischemic event.
    Type: Application
    Filed: March 31, 2022
    Publication date: July 14, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Itzhak Zachi Attia, Paul A. Friedman, Samuel J. Asirvatham, Peter A. Noseworthy, Suraj Kapa, Francisco Lopez-Jimenez
  • Publication number: 20220212010
    Abstract: A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.
    Type: Application
    Filed: January 18, 2022
    Publication date: July 7, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Samuel J. Asirvatham
  • Publication number: 20220189634
    Abstract: Provided herein are methods, systems, and computer program products for the detection of pulmonary hypertension comprising receiving voltage-time data of a plurality of leads of an electrocardiograph of a subject; generating a feature vector from the voltage-time data; providing the feature vector to a pretrained learning system; and receiving from the pretrained learning system an indication of the presence or absence of pulmonary hypertension in the subject.
    Type: Application
    Filed: October 13, 2021
    Publication date: June 16, 2022
    Inventors: Tyler Wagner, Samir Awasthi Awasthi, Venkataramanan Soundararajan, Murali Aravamudan, Corinne Carpenter, Katherine Carlson, Itzhak Zachi Attia, Paul A. Friedman, Samuel J. Asirvatham, Surai Kapa, Francisco Lopez-Jimenez, Hilary M. Dubrock
  • Patent number: 11337749
    Abstract: Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: May 24, 2022
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Christopher V. DeSimone, Barham K. Abu Dayyeh, Samuel J. Asirvatham
  • Patent number: 11337637
    Abstract: Systems, methods, devices, and techniques for analyzing and applying features of a T-wave derived from an electrocardiogram. A computing system can receive a set of data that characterizes an electrocardiogram of a patient. The system can analyze the set of data to identify a T-wave that occurs in the electrocardiogram. The system can determine values of one or more features of the T-wave and provide the information that identifies the values of the one or more features of the T-wave to a user.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: May 24, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Peter A. Noseworthy, Bo Qiang, Paul A. Friedman, Alan M. Sugrue, Vaclav Kremen, Bryan L. Striemer, Charles J. Bruce, Virend K. Somers, Kevin E. Bennet, Michael J. Ackerman, Samuel J. Asirvatham, John J. Dillon, Christopher V. DeSimone
  • Patent number: 11324431
    Abstract: Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The ECG circuit board and the plurality of IC circuit boards share substantially a same circuit configuration and components. The ECG circuit board further processes the ECG signal using substantially a same path as each IC circuit board uses to process its corresponding IC signal.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: May 10, 2022
    Assignees: BioSig Technologies, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Budimir S. Drakulic, Sina Fakhar, Thomas G. Foxall, Branislav Vlajinic, Samuel J. Asirvatham
  • Patent number: 11317872
    Abstract: Apparatuses and methods are provided to predict or diagnose an ischemic event, such as a stroke or a transient ischemic attack (TIA). A machine-learning model such as a neural network is generated that allows for recognition of an ECG consistent with an ischemic event. A system is trained and used to process a recording of ECG data from a patient to generate a prediction indicating a likelihood that the patient will experience a stroke. In other examples, a system is trained and used to process a recording of ECG data from a patient and detect an ischemic event for the patient who did not appear to have such an ischemic event.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 3, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Itzhak Zachi Attia, Paul A. Friedman, Samuel J. Asirvatham, Peter A. Noseworthy, Suraj Kapa, Francisco Lopez-Jimenez
  • Publication number: 20220071801
    Abstract: Devices and methods are provided for the treatment of pathological conditions including arrhythmias and trauma using temperature modulation via implantable or worn devices. For example, in one example embodiment this document relates to devices and methods for treating atrial or ventricular fibrillation by cooling the epicardium. The devices and methods can also be used to treat other disorders by applying heating and/or cooling to a patient in a number of different manners.
    Type: Application
    Filed: November 19, 2021
    Publication date: March 10, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Douglas S. Beinborn
  • Publication number: 20220071700
    Abstract: Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.
    Type: Application
    Filed: November 17, 2021
    Publication date: March 10, 2022
    Inventors: Christopher V. DESIMONE, Barham K. ABU DAYYEH, Samuel J. ASIRVATHAM
  • Patent number: 11260228
    Abstract: A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: March 1, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Samuel J. Asirvatham
  • Publication number: 20220047686
    Abstract: Various methods and devices of treating infectious diseases are described. In one example embodiment, a method of treating an infectious disease in an individual in need thereof is provided, including administering a therapeutic agent to the individual and electroporating a tissue of the individual, wherein the therapeutic agent is inhalable.
    Type: Application
    Filed: July 23, 2021
    Publication date: February 17, 2022
    Inventor: Samuel J. Asirvatham
  • Patent number: 11219772
    Abstract: This document relates to methods and materials for improving artificial cardiac pacing and/or resynchronization. For example, this document relates to methods and devices for artificial cardiac pacing and/or resynchronization by stimulating the His bundle.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: January 11, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman
  • Patent number: 11191459
    Abstract: Systems, methods, and other techniques for estimating the level of an analyte present in a patient during a time interval using electrocardiogram (ECG) signals. The estimate can be improved using information about the patient's posture.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: December 7, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Paul A. Friedman, Michael J. Ackerman, Samuel J. Asirvatham, Itzhak Zachi Attia, Kevin E. Bennet, Charles J. Bruce, John J. Dillon, Jennifer L. Dugan, Dorothy J. Ladewig, Virend K. Somers
  • Patent number: 11179270
    Abstract: Devices and methods are provided for the treatment of pathological conditions including arrhythmias and trauma using temperature modulation via implantable or worn devices. For example, in one example embodiment this document relates to devices and methods for treating atrial or ventricular fibrillation by cooling the epicardium. The devices and methods can also be used to treat other disorders by applying heating and/or cooling to a patient in a number of different manners.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: November 23, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Douglas S. Beinborn