Patents by Inventor Samuel J. Asirvatham
Samuel J. Asirvatham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8538501Abstract: A mapping and ablation catheter system including a radio frequency ablation source having an output, a mapping device, a catheter, and two or more capacitive components. The catheter may include two or more catheter electrodes, wherein two of the two or more catheter electrodes may be electrically coupled to the mapping device. Each of the two or more catheter electrodes may be electrically coupled to a capacitive component, wherein each capacitive component may be electrically coupled to the output of the radio frequency ablation source such that energy delivered to each catheter electrode of the two or more catheter electrodes passes through the capacitive component.Type: GrantFiled: January 9, 2009Date of Patent: September 17, 2013Assignee: Mayo Foundation for Medical Education and ResearchInventors: Kalpathi Venkatachalam, Samuel J. Asirvatham
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Patent number: 8409192Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.Type: GrantFiled: February 20, 2009Date of Patent: April 2, 2013Assignee: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
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Patent number: 8388674Abstract: Materials and methods for making conformable stents. The stents can be generated by, for example, injecting a fluid into a scaffold on the outer surface of an angioplasty balloon inflated at the site of a stenosis, and allowing the fluid to harden or set, thus generating a stent that can remain in the vessel at the site of stenosis.Type: GrantFiled: February 25, 2009Date of Patent: March 5, 2013Assignee: Mayo Foundation for Medical Education and ResearchInventors: Gurpreet S. Sandhu, Dan Dragomir Daescu, Charanjit S. Rihal, Samuel J. Asirvatham
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Publication number: 20130012938Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.Type: ApplicationFiled: December 3, 2010Publication date: January 10, 2013Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Samuel J. Asirvatham, Mark B. Knudson
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Publication number: 20120330351Abstract: Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.Type: ApplicationFiled: September 30, 2010Publication date: December 27, 2012Applicants: Aegis Medical Innovations Inc., Mayo Foundation for Medical ReearchInventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
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Publication number: 20120327204Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.Type: ApplicationFiled: September 30, 2010Publication date: December 27, 2012Applicants: Aegis Medical Innovations Inc., Mayo Foundation for Medical Education and ResearchInventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
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Patent number: 8315716Abstract: The invention describes a steerable sheath for percutaneous epicardial access. The invention also describes a novel lead to facilitate left ventricular pacing and efficient defibrillation.Type: GrantFiled: October 9, 2009Date of Patent: November 20, 2012Assignee: Mayo Foundation for Medical Education and ResearchInventors: Paul A Friedman, Charles J Bruce, Samuel J Asirvatham
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Publication number: 20120245665Abstract: An electrical lead for a cardiac device includes a body having a distal end sized for insertion through a catheter, first and second electrodes extending through the body, with each electrode terminating in a tip having proximal and distal ends and arranged to extend to an area of cardiac tissue. The tips include a fully insulated portion on the proximal and distal ends measuring in a range between 5 percent and 40 percent of the lengths of the tips, and further include an uninsulated intermediate section. The tip of the second electrode includes a helical section surrounding the first electrode and has an insulated portion on an inwardly facing portion surface facing toward the first electrode. The tip of the second electrode also includes a fully insulated portion on the proximal and distal ends measuring in the same or similar percentage range.Type: ApplicationFiled: September 2, 2010Publication date: September 27, 2012Applicant: MAYO FOUNDATIONFOR MEDICAL EDUCATION AND RESEARCHInventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham
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Publication number: 20120220890Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.Type: ApplicationFiled: May 10, 2012Publication date: August 30, 2012Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, JR.
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Patent number: 8204600Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.Type: GrantFiled: November 21, 2006Date of Patent: June 19, 2012Assignee: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, Jr.
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Publication number: 20120150171Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/C1fA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.Type: ApplicationFiled: February 13, 2012Publication date: June 14, 2012Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B.C. Lim, Kalpathi L. Venkatachalam
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Publication number: 20120143099Abstract: Systems and methods for impairing smooth muscle tissue function using energy and/or pressure are described herein. The systems and/or methods may be used in some embodiments to target smooth muscle tissue in the bronchial passages.Type: ApplicationFiled: June 1, 2010Publication date: June 7, 2012Applicant: Mayo Foundation for Medical Education and ResearchInventors: Craig E. Daniels, Samuel J. Asirvatham, Dorothy J. Ladewig
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Patent number: 8162936Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.Type: GrantFiled: February 20, 2009Date of Patent: April 24, 2012Assignee: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
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Publication number: 20120059459Abstract: This document relates to materials and methods for circulatory bypass of a ventricle in the heart of a mammal. For example, materials and methods for bypassing a permanently or temporarily impaired left ventricle in the heart of a mammal (e.g., a human) are provided.Type: ApplicationFiled: May 11, 2010Publication date: March 8, 2012Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Samuel J. Asirvatham, Soon J. Park, Paul A. Friedman, Charles J. Bruce, Sudhir S. Kushwaha
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Publication number: 20120022558Abstract: Devices and methods for ligating structures where the loop of the ligation element can be temporarily pre-tightened without locking the loop. This pre-tightening without locking allows the loop of the ligation element to be loosened and repositioned, if necessary, before locking the loop around the anatomical structure.Type: ApplicationFiled: October 20, 2009Publication date: January 26, 2012Applicant: Mayo Foundation for Medical Education and ResearchInventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
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Publication number: 20110224655Abstract: Intracardiac devices that can provide a plurality of functions (e.g., pacing, defibrillation, cardiac assist, or valve replacement) via a single support member and control means.Type: ApplicationFiled: September 11, 2009Publication date: September 15, 2011Inventors: Samuel J. Asirvatham, Charles J. Bruce, Paul A. Friedman, Giovanni Speziali
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Publication number: 20110190756Abstract: A mapping and ablation catheter system including a radio frequency ablation source having an output, a mapping device, a catheter, and two or more capacitive components. The catheter may include two or more catheter electrodes, wherein two of the two or more catheter electrodes may be electrically coupled to the mapping device. Each of the two or more catheter electrodes may be electrically coupled to a capacitive component, wherein each capacitive component may be electrically coupled to the output of the radio frequency ablation source such that energy delivered to each catheter electrode of the two or more catheter electrodes passes through the capacitive component.Type: ApplicationFiled: January 9, 2009Publication date: August 4, 2011Applicant: Mayo Foundation for Medical Education and ResearchInventors: Kalpathi Venkatachalam, Samuel J. Asirvatham
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Publication number: 20110178539Abstract: This document provides methods and materials related to minimally invasive techniques for reducing the volume of and/or occluding left atrial appendages.Type: ApplicationFiled: July 8, 2009Publication date: July 21, 2011Inventors: David R. Holmes, Jr., David R. Holmes, III, Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Susan B. Johnson, Rebecca B. Fountain
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Publication number: 20110112569Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.Type: ApplicationFiled: March 27, 2009Publication date: May 12, 2011Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, AEGIS MEDICAL INNOVATIONS INC.Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.k. Hong
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Publication number: 20100331809Abstract: Materials and methods for making conformable stents. The stents can be generated by, for example, injecting a fluid into a scaffold on the outer surface of an angioplasty balloon inflated at the site of a stenosis, and allowing the fluid to harden or set, thus generating a stent that can remain in the vessel at the site of stenosis.Type: ApplicationFiled: February 25, 2009Publication date: December 30, 2010Inventors: Gurpreet S. Sandhu, Dan Dragomir Daescu, Charanjit S. Rihal, Samuel J. Asirvatham