Patents by Inventor Samuel J. Asirvatham

Samuel J. Asirvatham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8538501
    Abstract: A mapping and ablation catheter system including a radio frequency ablation source having an output, a mapping device, a catheter, and two or more capacitive components. The catheter may include two or more catheter electrodes, wherein two of the two or more catheter electrodes may be electrically coupled to the mapping device. Each of the two or more catheter electrodes may be electrically coupled to a capacitive component, wherein each capacitive component may be electrically coupled to the output of the radio frequency ablation source such that energy delivered to each catheter electrode of the two or more catheter electrodes passes through the capacitive component.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: September 17, 2013
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Kalpathi Venkatachalam, Samuel J. Asirvatham
  • Patent number: 8409192
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: April 2, 2013
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
  • Patent number: 8388674
    Abstract: Materials and methods for making conformable stents. The stents can be generated by, for example, injecting a fluid into a scaffold on the outer surface of an angioplasty balloon inflated at the site of a stenosis, and allowing the fluid to harden or set, thus generating a stent that can remain in the vessel at the site of stenosis.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: March 5, 2013
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Gurpreet S. Sandhu, Dan Dragomir Daescu, Charanjit S. Rihal, Samuel J. Asirvatham
  • Publication number: 20130012938
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Application
    Filed: December 3, 2010
    Publication date: January 10, 2013
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Publication number: 20120330351
    Abstract: Systems and methods capture and/or occlusion of selected body tissue using various tissue characteristics and/or techniques are described. In the context of left atrial appendage closure, the systems and methods can be used to capture the left atrial appendage while a closure instrument (suture, clip, ring, etc.) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage.
    Type: Application
    Filed: September 30, 2010
    Publication date: December 27, 2012
    Applicants: Aegis Medical Innovations Inc., Mayo Foundation for Medical Reearch
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
  • Publication number: 20120327204
    Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
    Type: Application
    Filed: September 30, 2010
    Publication date: December 27, 2012
    Applicants: Aegis Medical Innovations Inc., Mayo Foundation for Medical Education and Research
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
  • Patent number: 8315716
    Abstract: The invention describes a steerable sheath for percutaneous epicardial access. The invention also describes a novel lead to facilitate left ventricular pacing and efficient defibrillation.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: November 20, 2012
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Paul A Friedman, Charles J Bruce, Samuel J Asirvatham
  • Publication number: 20120245665
    Abstract: An electrical lead for a cardiac device includes a body having a distal end sized for insertion through a catheter, first and second electrodes extending through the body, with each electrode terminating in a tip having proximal and distal ends and arranged to extend to an area of cardiac tissue. The tips include a fully insulated portion on the proximal and distal ends measuring in a range between 5 percent and 40 percent of the lengths of the tips, and further include an uninsulated intermediate section. The tip of the second electrode includes a helical section surrounding the first electrode and has an insulated portion on an inwardly facing portion surface facing toward the first electrode. The tip of the second electrode also includes a fully insulated portion on the proximal and distal ends measuring in the same or similar percentage range.
    Type: Application
    Filed: September 2, 2010
    Publication date: September 27, 2012
    Applicant: MAYO FOUNDATIONFOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham
  • Publication number: 20120220890
    Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
    Type: Application
    Filed: May 10, 2012
    Publication date: August 30, 2012
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, JR.
  • Patent number: 8204600
    Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: June 19, 2012
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, Jr.
  • Publication number: 20120150171
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/C1fA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Application
    Filed: February 13, 2012
    Publication date: June 14, 2012
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B.C. Lim, Kalpathi L. Venkatachalam
  • Publication number: 20120143099
    Abstract: Systems and methods for impairing smooth muscle tissue function using energy and/or pressure are described herein. The systems and/or methods may be used in some embodiments to target smooth muscle tissue in the bronchial passages.
    Type: Application
    Filed: June 1, 2010
    Publication date: June 7, 2012
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Craig E. Daniels, Samuel J. Asirvatham, Dorothy J. Ladewig
  • Patent number: 8162936
    Abstract: Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: April 24, 2012
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Arshad Jahangir, Bernard B. C. Lim, Kalpathi L. Venkatachalam
  • Publication number: 20120059459
    Abstract: This document relates to materials and methods for circulatory bypass of a ventricle in the heart of a mammal. For example, materials and methods for bypassing a permanently or temporarily impaired left ventricle in the heart of a mammal (e.g., a human) are provided.
    Type: Application
    Filed: May 11, 2010
    Publication date: March 8, 2012
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Samuel J. Asirvatham, Soon J. Park, Paul A. Friedman, Charles J. Bruce, Sudhir S. Kushwaha
  • Publication number: 20120022558
    Abstract: Devices and methods for ligating structures where the loop of the ligation element can be temporarily pre-tightened without locking the loop. This pre-tightening without locking allows the loop of the ligation element to be loosened and repositioned, if necessary, before locking the loop around the anatomical structure.
    Type: Application
    Filed: October 20, 2009
    Publication date: January 26, 2012
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.K. Hong
  • Publication number: 20110224655
    Abstract: Intracardiac devices that can provide a plurality of functions (e.g., pacing, defibrillation, cardiac assist, or valve replacement) via a single support member and control means.
    Type: Application
    Filed: September 11, 2009
    Publication date: September 15, 2011
    Inventors: Samuel J. Asirvatham, Charles J. Bruce, Paul A. Friedman, Giovanni Speziali
  • Publication number: 20110190756
    Abstract: A mapping and ablation catheter system including a radio frequency ablation source having an output, a mapping device, a catheter, and two or more capacitive components. The catheter may include two or more catheter electrodes, wherein two of the two or more catheter electrodes may be electrically coupled to the mapping device. Each of the two or more catheter electrodes may be electrically coupled to a capacitive component, wherein each capacitive component may be electrically coupled to the output of the radio frequency ablation source such that energy delivered to each catheter electrode of the two or more catheter electrodes passes through the capacitive component.
    Type: Application
    Filed: January 9, 2009
    Publication date: August 4, 2011
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Kalpathi Venkatachalam, Samuel J. Asirvatham
  • Publication number: 20110178539
    Abstract: This document provides methods and materials related to minimally invasive techniques for reducing the volume of and/or occluding left atrial appendages.
    Type: Application
    Filed: July 8, 2009
    Publication date: July 21, 2011
    Inventors: David R. Holmes, Jr., David R. Holmes, III, Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Susan B. Johnson, Rebecca B. Fountain
  • Publication number: 20110112569
    Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.
    Type: Application
    Filed: March 27, 2009
    Publication date: May 12, 2011
    Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, AEGIS MEDICAL INNOVATIONS INC.
    Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y.k. Hong
  • Publication number: 20100331809
    Abstract: Materials and methods for making conformable stents. The stents can be generated by, for example, injecting a fluid into a scaffold on the outer surface of an angioplasty balloon inflated at the site of a stenosis, and allowing the fluid to harden or set, thus generating a stent that can remain in the vessel at the site of stenosis.
    Type: Application
    Filed: February 25, 2009
    Publication date: December 30, 2010
    Inventors: Gurpreet S. Sandhu, Dan Dragomir Daescu, Charanjit S. Rihal, Samuel J. Asirvatham