Patents by Inventor Samuel JESKE

Samuel JESKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HEPATITIS B AND/OR HEPATITIS D-PERMISSIVE CELLS AND ANIMALS
    Publication number: 20210269499
    Abstract: The present invention relates to a porcine sodium taurocholate cotransporter polypeptide (NTCP) mutein, which has been modified at sequence positions 157-167 with the human sequence. This NTCP mutein renders a host cell and a transgenic animal susceptible for an infection with hepatitis B virus (HBV) and/or hepatitis D virus (HDV). The present invention further relates to a nucleic acid and a vector comprising the NTCP mutein of the invention. Also presented are methods for producing cells and transgenic animals, which are susceptible to HBV and/or HDV as well as uses of the NTCP mutein screening for compounds or rendering a cell susceptible for an infection with HBV and/or HDV. Additionally provided is a method for identifying a compound, which is useful in the prevention and/or treatment of HBV and/or HDV infection.
    Type: Application
    Filed: June 21, 2019
    Publication date: September 2, 2021
    Applicant: TECHNISCHE UNIVERSITAET MUENCHEN
    Inventors: Ulrike PROTZER, Jochen WETTENGEL, Samuel JESKE, Konrad FISCHER, Angelika SCHNIEKE