Abstract: The present disclosure provides methods and compositions for immunotherapy employing a modified T cell or NK cell comprising a chimeric LILRB4 antigen receptor (CAR) that can be administered to patients for disease (e.g., cancer) treatment.

Abstract: Systems and methods are provided for automated metadata tag score determination that leverages machine learning (ML) models and weighted knowledge graphs to obtain and assign metadata tag scores to instances of underlying data. Examples include generating a domain-specific knowledge graph related to a particular domain. The domain-specific knowledge graph comprising a plurality of domain-specific features connected via a plurality of domain-specific relationships. Responsive to receiving an input tag, examples extract domain-specific features of the plurality of domain-specific features associated with the input tag and a subset of domain-specific relationships of the plurality of domain-specific relationships corresponding to the subset of domain-specific features.

Abstract: The present disclosure provides methods and compositions for immunotherapy employing a modified T cell or NK cell comprising a chimeric LILRB4 antigen receptor (CAR) that can be administered to patients for disease (e.g., cancer) treatment.

Abstract: A computer-implemented system and method can be used to identify policy information applicable to a compute resource within a specified time range, the policy information related to data management for the compute resource. Based on the identified policy information, a set of expected data management events for the compute resource is generated within the specified time range. The set of expected data protection events is modified based on information related to exceptions to the data management indicated by the policy information. The modified set of data protection events provides lineage information for the compute resource.

Abstract: The invention relates to a patient-specific implant (5) for insertion into a body cavity of a patient, for example into the round window niche of the middle ear. The invention also relates to a method of manufacturing such an implant (5).

Abstract: The present disclosure provides methods and compositions for immunotherapy employing a modified T cell or NK cell comprising a chimeric LILRB4 antigen receptor (CAR) that can be administered to patients for disease (e.g., cancer) treatment.

Abstract: A positioning aid for surgical procedures has a carrier system and a template. The carrier system consists of a carrier plate, which is provided with a recess, and supports. The carrier plate can be secured to a cranial bone via the supports over an operating field for the surgical procedure. The template has a template plate which can be connected to the carrier plate in a play-free manner and which comprises a guiding aperture. The guiding aperture is arranged and oriented in the template plate, which consists of a blank, in an individualized manner according to coordinates ascertained in advance. The central longitudinal axis of the guiding aperture matches a trajectory for accessing the operating field for the surgical procedure when the carrier system and the template are assembled and the carrier system is secured to the cranial bone.

Abstract: A positioning aid for surgical procedures has a carrier system and a template. The carrier system consists of a carrier plate, which is provided with a recess, and supports. The carrier plate can be secured to a cranial bone via the supports over an operating field for the surgical procedure. The template has a template plate which can be connected to the carrier plate in a play-free manner and which comprises a guiding aperture. The guiding aperture is arranged and oriented in the template plate, which consists of a blank, in an individualized manner according to coordinates ascertained in advance. The central longitudinal axis of the guiding aperture matches a trajectory for accessing the operating field for the surgical procedure when the carrier system and the template are assembled and the carrier system is secured to the cranial bone.