Patents by Inventor Samuel K. Martin
Samuel K. Martin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140243402Abstract: The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.Type: ApplicationFiled: February 4, 2014Publication date: August 28, 2014Applicant: The United States of America as represented by the Secretary of the ArmyInventors: Bruno K. Kubata, Samuel K. Martin, Wilbur K. Milhous
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Patent number: 8715751Abstract: The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.Type: GrantFiled: July 16, 2009Date of Patent: May 6, 2014Assignee: The United States of America as Represented by the Secretary of the ArmyInventors: Bruno K. Kubata, Samuel K. Martin, Wilbur K. Milhous
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Patent number: 7993917Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.Type: GrantFiled: August 20, 2009Date of Patent: August 9, 2011Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Samuel K. Martin
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Publication number: 20100092938Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.Type: ApplicationFiled: August 20, 2009Publication date: April 15, 2010Inventor: Samuel K. Martin
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Publication number: 20090317499Abstract: The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.Type: ApplicationFiled: July 16, 2009Publication date: December 24, 2009Inventors: Bruno K. Kubata, Samuel K. Martin, Wilbur K. Milhous
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Patent number: 7611896Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.Type: GrantFiled: June 13, 2005Date of Patent: November 3, 2009Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Samuel K. Martin
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Patent number: 7566465Abstract: The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.Type: GrantFiled: December 21, 2006Date of Patent: July 28, 2009Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Bruno K. Kubata, Samuel K. Martin, Wilbur K. Milhous
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Patent number: 7452721Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.Type: GrantFiled: November 18, 2004Date of Patent: November 18, 2008Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Samuel K. Martin
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Publication number: 20080152729Abstract: The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.Type: ApplicationFiled: December 21, 2006Publication date: June 26, 2008Inventors: Bruno K. Kubata, Samuel K. Martin, Wilbur K. Milhous
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Patent number: 7008774Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.Type: GrantFiled: June 18, 2002Date of Patent: March 7, 2006Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Jeffrey R. Ryan, Samuel K. Martin, Anthony M. Smithyman
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Publication number: 20030008332Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.Type: ApplicationFiled: June 18, 2002Publication date: January 9, 2003Inventors: Jeffrey R. Ryan, Samuel K. Martin, Anthony M. Smithyman
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Publication number: 20020064801Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.Type: ApplicationFiled: November 29, 2000Publication date: May 30, 2002Inventors: Jeffrey R. Ryan, Samuel K. Martin, Anthony M. Smithyman
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Patent number: 5199731Abstract: A step assembly (438) includes two step supporting members (444) which have proximal ends pivotally attached to the underside of a mounting bracket (440). The step supporting members (444) support a plurality of rungs (445). A step plate (446) is attached in cantilevered manner to each of the rungs (445) whereby a rear one of the step supporting members (444) is intermediate the step plate (446) and the front step supporting member. A transmission assembly is provided for causing distal ends of the step supporting members to contact the ground (G) and thereby acquire an extended, angularly inclined position. In one embodiment, the transmission assembly includes an actuator (470). In another embodiment, the transmission assembly includes a motor and cable assembly (472).Type: GrantFiled: November 26, 1991Date of Patent: April 6, 1993Inventor: Samuel K. Martin
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Patent number: 5137294Abstract: A folding step apparatus (38) is provided for vehicles having either a hinged door (26) or a sliding door (26'). The apparatus includes two parallel step supporting members (44) pivotally attached to the underside of the vehicle for adjustably supporting a step (42) or plurality of steps. A spring member (46) is used to bias the supporting members (44) and attached steps to a retracted position beneath the vehicle. A cable (64) has a first end attached to the locking end of the door and a second end attached to a front one of the supporting members (44). The cable is at least partially disposed within a hollow cord (70) which extends through portions of the vehicle frame. Opening the vehicle door causes the folding step assembly (38) to pivot about an axis perpendicular to the longitudinal horizontal axis (36) of the vehicle, thereby extending the step assembly (38) for facilitating easy boarding of the vehicle.Type: GrantFiled: September 4, 1990Date of Patent: August 11, 1992Inventor: Samuel K. Martin
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Patent number: 4897403Abstract: An antimalarial composition contains as the active ingredient a mixture of chemical compound effective in reversing the resistance of cancer cells to chemotherapy drugs and at least one antimalarial agent. A method for treating malaria in mammals comprises administering a composition containing the active ingredient. A method for reducing the resistance of a malarial parasite to an antimalarial agent comprises administering a composition containing the active ingredient.Type: GrantFiled: November 18, 1986Date of Patent: January 30, 1990Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Samuel K. Martin, Ayo M. J. Oduola, Wilbur K. Milhous