Patents by Inventor Samuel K. Sia
Samuel K. Sia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170227537Abstract: Diagnostic systems, methods, and devices employing low-cost handheld components are disclosed herein. A diagnostic system can include a diagnostic device that is configured to perform one or more assays on a fluid sample, such as a whole blood sample, in one or more microfluidic channels or chambers. The diagnostic device can move the fluid sample into or through the one or more microfluidic channels or chambers without using any electrical power, for example, using manual actuation to generate a positive or negative pressure within the diagnostic device. The diagnostic device can have a connector for interfacing with a separate handheld unit that can provide power and data processing. For example, the separate handheld unit can be a smartphone or PDA, and the connector can interface with an existing input/output port of the unit to draw power and/or transmit data.Type: ApplicationFiled: August 13, 2015Publication date: August 10, 2017Applicant: The Trustees of Columbia University in the City of New YorkInventors: Tiffany GUO, Samuel K. SIA, Jeisun Shi XIE, Fanxing MENG, Keith YEAGER
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Publication number: 20170191035Abstract: Provided are methods, apparatus, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes, by administration to a subject of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues or brown adipose tissue directly converted from white adipose tissue. Modified approaches to creating brown adipose tissue involve differentiation of explanted white adipose tissue and direct browning of white adipose tissue in a bioreactor rather than isolation and expansion of adipose stems cells or endothelial cells and formation and differentiation of 3D cell aggregates.Type: ApplicationFiled: July 10, 2015Publication date: July 6, 2017Applicant: The Trustees of Columbia University in the City of New YorkInventors: Samuel K. SIA, Brian M. GILLETTE
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Patent number: 9683993Abstract: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area.Type: GrantFiled: April 10, 2013Date of Patent: June 20, 2017Assignees: President and Fellows of Harvard College, OPKO Diagnostics, LLCInventors: Vincent Linder, Samuel K. Sia, George M. Whitesides, Max Narovlyansky, Adam Carlyn Siegel
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Publication number: 20160324991Abstract: Microfabricated platforms can be used to study a heterogeneous panel of biosamples in a realistic in vivo setting. The platform can be formed of a polymer (e.g., a hydrogel) and can be constructed for implantation into an animal host for in vivo testing. The platform can have a plurality of testing regions therein that are constructed to allow exposure of the testing region to the host stroma when implanted in vivo. For example, the microfabricated platform can be used for screening different cancer cell-lines (e.g., to identify which cell line responds to an anti-cancer drug) or for screening different biomaterials (e.g., to identify a composition with ideal host response for a specific implantable device).Type: ApplicationFiled: July 18, 2016Publication date: November 10, 2016Applicant: The Trustees of Columbia University in the City of New YorkInventors: Samuel K. SIA, Hesam PARSA
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Publication number: 20160305938Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: ApplicationFiled: June 29, 2016Publication date: October 20, 2016Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Publication number: 20160077087Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: ApplicationFiled: November 24, 2015Publication date: March 17, 2016Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Patent number: 9268911Abstract: A portable unitary device handheld diagnostic device can be operated with minimal power requirement and provides ease of operation as well as low cost communication of diagnostic data from remote locations. The device can provide nucleic-acid based diagnostics with minimal training, little to no sample preparation, and generates diagnostic data in about 45 minutes. A system can enable point of care transmission from any location globally using a low cost satellite-based data link technique, for example, Short Burst Data (SBD), combined with data encoding.Type: GrantFiled: July 23, 2014Date of Patent: February 23, 2016Assignee: The Trustees of Columbia University in the City of New YorkInventors: Samuel K. Sia, Mario Matteo Modena, Paolo Cadinu, Keith Yeager, Yuk Kee Cheung Poh, Robert Houghtaling, Tassaneewan Laksanasopin, Curtis D. Chin
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Publication number: 20160029937Abstract: Devices systems and methods for fluid extraction and delivery to human or animal hosts are described. In embodiments, microneedles are employed to provide low infection risk and painless access to and administration of fluids. The disclosed embodiments address, among others, issues of cost, portability, ease of use in remote settings including use by untrained personnel, and others.Type: ApplicationFiled: March 26, 2014Publication date: February 4, 2016Inventors: Samuel K. SIA, Nalin TEJAVIBULYA
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Patent number: 9234888Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: GrantFiled: November 26, 2014Date of Patent: January 12, 2016Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Patent number: 9188243Abstract: Microfabricated microvalves may be used with liquid-filled control channels and actuated using compact and battery-powered components, without the need for heavier or fixed infrastructure. The disclosed embodiments include microvalves with on-off fluid control with relatively fast response times, coordinated switching of multiple valves, and operation of a biological (enzyme-substrate) assay in a handheld configuration.Type: GrantFiled: January 28, 2011Date of Patent: November 17, 2015Assignee: The Trustees of Columbia University in the City of New YorkInventors: Kweku Addae-Mensah, Yuk Kee Cheung, Samuel K. Sia
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Patent number: 9116148Abstract: A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process.Type: GrantFiled: January 31, 2013Date of Patent: August 25, 2015Assignee: President and Fellows of Harvard CollegeInventors: Vincent Linder, Samuel K. Sia, George M. Whitesides
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Publication number: 20150233901Abstract: A method and apparatus for delivering one or more fluids. Fluids may be delivered from a common vessel to a chemical, biological or biochemical process.Type: ApplicationFiled: May 1, 2015Publication date: August 20, 2015Applicant: President and Fellows of Harvard CollegeInventors: Vincent Linder, Samuel K. Sia, George M. Whitesides
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Patent number: 9075047Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: GrantFiled: March 21, 2014Date of Patent: July 7, 2015Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Publication number: 20150079606Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: ApplicationFiled: November 26, 2014Publication date: March 19, 2015Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Patent number: 8921121Abstract: A chemiluminescence-based detection system and method for counting blood cells by capturing and isolating target blood cells flowing through a microfluidic chip and detecting light emitted by the captured target blood cells.Type: GrantFiled: August 20, 2010Date of Patent: December 30, 2014Assignee: The Trustees of Columbia University in the City of New YorkInventors: Zuankai Wang, Sau Yin Chin, Samuel K. Sia
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Publication number: 20140333453Abstract: A portable unitary device handheld diagnostic device can be operated with minimal power requirement and provides ease of operation as well as low cost communication of diagnostic data from remote locations. The device can provide nucleic-acid based diagnostics with minimal training, little to no sample preparation, and generates diagnostic data in about 45 minutes. A system can enable point of care transmission from any location globally using a low cost satellite-based data link technique, for example, Short Burst Data (SBD), combined with data encoding.Type: ApplicationFiled: July 23, 2014Publication date: November 13, 2014Inventors: Samuel K. SIA, Mario Matteo MODENA, Paolo CADINU, Keith YEAGER, Yuk Kee Cheung POH, Robert HOUGHTALING, Tassaneewan LAKSANASOPIN, Curtis D. CHIN
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Publication number: 20140220687Abstract: Methods and systems forming biocompatible materials are disclosed herein. Forming a biocompatible material may include contacting a liquid, having a linking material, with an adjoining material having embedded therein a nucleating material that causes the linking material to nucleate and grow into the liquid. After a time sufficient to cause the linking material to grow substantially from the nucleating material into a space occupied by the liquid, the liquid may be solidified to form a solid such that the linking material secures the solid to the adjoining material.Type: ApplicationFiled: November 7, 2013Publication date: August 7, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Samuel K. SIA, Brian Michael GILLETTE
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Publication number: 20140205997Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.Type: ApplicationFiled: March 21, 2014Publication date: July 24, 2014Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller, Samuel K. Sia
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Publication number: 20140134603Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.Type: ApplicationFiled: September 30, 2013Publication date: May 15, 2014Inventors: Samuel K. Sia, Vincent Linder, Babak Amir-parviz, Adam Siegel, George M. Whitesides
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Publication number: 20140038167Abstract: A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process.Type: ApplicationFiled: January 31, 2013Publication date: February 6, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: VINCENT LINDER, SAMUEL K. SIA, GEORGE M. WHITESIDES