Abstract: Methods and systems for detecting container leakage using thermal imaging, for example, infrared imaging, are disclosed. A method may include a step of sensing thermal radiation emanating from a scene encompassing a liquid-holding container. For example, the container may be an intravenous fluid bag. The method may also include a step of generating a thermal image of the scene based on the sensed thermal radiation and a step of analyzing the thermal image by assessing whether the thermal image includes a thermal feature indicative of the presence of leaked liquid outside the container to determine whether a leak exists in the container. In some embodiments, the container may be enclosed in an overwrap. In such a case, the assessed thermal feature may be indicative of liquid being present in an interstitial volume defined between the container and the overwrap.