Patents by Inventor Samuel P. Yenne
Samuel P. Yenne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11427860Abstract: Methods are disclosed for identifying antibacterial compounds which inhibit propagation of selected spectrum bacteria, which bacteria use specific tRNA to code for Ala, Met, Ser, or Leu that other bacteria do not use. In one embodiment, the selected spectrum bacteria use GCA to code for Ala, whereas other bacteria use a different codon to code for alanine. The methods involve determining whether putative inhibitors promote or inhibit complex formation between the tRNA and a bacterial ribosome, or between the tRNA and an aminoacyl synthetase. Compounds which promote or inhibit complex formation can disrupt protein production, which bacteria need to propagate. The identified antibacterial compounds can selectively inhibit bacterial propagation. By limiting their effects to the selected spectrum bacteria, these compounds can treat or prevent specific bacterial infections without disrupting the normal bacterial flora, the patients' microbiome, or causing antibacterial resistance.Type: GrantFiled: August 11, 2016Date of Patent: August 30, 2022Assignee: TRANA DISCOVERY, INC.Inventors: Steven E. Peterson, Samuel P. Yenne, Joseph Christopher Ellis, Richard H. Guenther
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Patent number: 10316371Abstract: Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.Type: GrantFiled: March 29, 2012Date of Patent: June 11, 2019Assignee: TRANA DISCOVERY, INC.Inventors: Richard H. Guenther, Samuel P. Yenne, Jerzy R. Szewczyk
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Publication number: 20190024152Abstract: Methods are disclosed for identifying antibacterial compounds which inhibit propagation of selected spectrum bacteria, which bacteria use specific tRNA to code for Ala, Met, Ser, or Leu that other bacteria do not use. In one embodiment, the selected spectrum bacteria use GCA to code for Ala, whereas other bacteria use a different codon to code for alanine. The methods involve determining whether putative inhibitors promote or inhibit complex formation between the tRNA and a bacterial ribosome, or between the tRNA and an aminoacyl synthetase. Compounds which promote or inhibit complex formation can disrupt protein production, which bacteria need to propagate. The identified antibacterial compounds can selectively inhibit bacterial propagation. By limiting their effects to the selected spectrum bacteria, these compounds can treat or prevent specific bacterial infections without disrupting the normal bacterial flora, the patients' microbiome, or causing antibacterial resistance.Type: ApplicationFiled: August 11, 2016Publication date: January 24, 2019Applicant: TRANA DISCOVERY, INC.Inventors: Steven E. PETERSON, Samuel P. YENNE, Joseph Christopher ELLIS, Richard H. GUENTHER
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Publication number: 20140163037Abstract: Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.Type: ApplicationFiled: March 29, 2012Publication date: June 12, 2014Applicant: TRANA DISCOVERY, INC.Inventors: Richard H. Guenther, Samuel P. Yenne, Jerzy R. Szewczyk
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Patent number: 8431341Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.Type: GrantFiled: June 28, 2010Date of Patent: April 30, 2013Assignee: Trana Discovery, Inc.Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
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Patent number: 8232378Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.Type: GrantFiled: August 24, 2009Date of Patent: July 31, 2012Assignee: Trana Discovery, Inc.Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
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Publication number: 20110306509Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.Type: ApplicationFiled: June 28, 2010Publication date: December 15, 2011Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
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Publication number: 20110229920Abstract: Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises inhibiting ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound, and then determining whether the compound inhibits the binding of that tRNA.Type: ApplicationFiled: September 24, 2009Publication date: September 22, 2011Applicant: TRANA DISCOVERY, INC.Inventors: Richard H. Guenther, Samuel P. Yenne
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Publication number: 20100069260Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.Type: ApplicationFiled: August 24, 2009Publication date: March 18, 2010Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
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Patent number: 7598040Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.Type: GrantFiled: November 21, 2007Date of Patent: October 6, 2009Assignee: Trana Discovery, Inc.Inventors: Richard H. Guenther, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz
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Publication number: 20080199870Abstract: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.Type: ApplicationFiled: November 21, 2007Publication date: August 21, 2008Inventors: Richard H. GUENTHER, Winnell H. Newman, Samuel P. Yenne, Dan Mitchell, Andrzej Malkiewicz