Patents by Inventor Samuel Padula

Samuel Padula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A PSEUDO-RANDOM DNA EDITOR FOR EFFICIENT AND CONTINUOUS NUCLEOTIDE DIVERSIFICATION IN HUMAN CELLS
    Publication number: 20220170006
    Abstract: The present disclosure provides compositions and methods for performance of targeted mutagenesis in higher eukaryotic cells, e.g., mammalian cells, across large stretches of targeted sequence. Compositions and methods that rely upon combination of a bacteriophage polymerase with a nucleic acid-editing deaminase to achieve robust mutagenesis of targeted regions of nucleic acid sequence under control of a phage promoter are specifically provided.
    Type: Application
    Filed: April 3, 2020
    Publication date: June 2, 2022
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Fei Chen, Haiqi Chen, Sophia Liu, Samuel Padula, Kettner Griswold