Patents by Inventor Samuel Pfaff

Samuel Pfaff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors for androgen antagonist refractory prostate cancer
    Publication number: 20070087352
    Abstract: The present invention relates to methods and antagonist compounds for modulating androgen receptor activity. The invention includes a method for identifying molecules that bind to a coactivator binding site of a receptor in the androgen receptor family. Also included is a cocrystal of an androgen receptor ligand binding domain complexed with a ligand and a coactivator. The invention further includes a method for inhibiting androgen receptor activity in a mammal, thereby facilitating treatment of diseases such as prostate cancer.
    Type: Application
    Filed: November 6, 2003
    Publication date: April 19, 2007
    Inventors: Robert Fletterick, Eva Estebanez-Perpina, Eugene Hur, Samuel Pfaff, Benjamin Buehrer
  • Inhibitors for androgen antagonist refractory prostate cancer
    Publication number: 20050202440
    Abstract: The present invention relates to methods and antagonist compounds for modulating androgen receptor activity. The invention includes a method for identifying molecules that bind to a coactivator binding site of a receptor in the androgen receptor family. Also included is a cocrystal of an androgen receptor ligand binding domain complexed with a ligand and a coactivator. The invention further includes a method for inhibiting androgen receptor activity in a mammal, thereby facilitating treatment of diseases such as prostate cancer.
    Type: Application
    Filed: November 6, 2003
    Publication date: September 15, 2005
    Inventors: Robert Fletterick, Eva Estebanez-Perpina, Eugene Hur, Samuel Pfaff, Benjamin Buehrer