Patents by Inventor Samuel Poore

Samuel Poore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Penetration of Cerebral Spinal Fluid into the Brain Parenchyma Using Temporally Patterned Neuromodulation
    Publication number: 20220331583
    Abstract: Electrical stimulation of specific facial and lingual nerves creates a more sustained pulsatility activity compared to stimulation of other cranial nerves. Pulsatility of arteries has intrinsic time constraints related to the time for vasodilation/constriction and time to return to baseline (TBL) after electrical stimulation which may affect the pulsatility response. Control of temporal patterning and the stimulation waveform maximizes the physiological response to cerebral pulsatility and its resulting effects on cerebral spinal fluid penetration into the brain parenchyma for a multitude of therapeutic uses including clearing misfolded proteins and/or administered pharmacological agents, diluting endogenous neurochemical concentrations within the brain, and reducing non-synaptic coupling.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 20, 2022
    Inventors: Kip Ludwig, Justin Williams, Angela Williams, Samuel Poore
  • Penetration of cerebral spinal fluid into the brain parenchyma using temporally patterned neuromodulation
    Patent number: 11395914
    Abstract: Electrical stimulation of specific facial and lingual nerves creates a more sustained pulsatility activity compared to stimulation of other cranial nerves. Pulsatility of arteries has intrinsic time constraints related to the time for vasodilation/constriction and time to return to baseline (TBL) after electrical stimulation which may affect the pulsatility response. Control of temporal patterning and the stimulation waveform maximizes the physiological response to cerebral pulsatility and its resulting effects on cerebral spinal fluid penetration into the brain parenchyma for a multitude of therapeutic uses including clearing misfolded proteins and/or administered pharmacological agents, diluting endogenous neurochemical concentrations within the brain, and reducing non-synaptic coupling.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: July 26, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Kip Ludwig, Justin Williams, Angela Williams, Samuel Poore
  • Penetration of Cerebral Spinal Fluid into the Brain Parenchyma Using Temporally Patterned Neuromodulation
    Publication number: 20210038884
    Abstract: Electrical stimulation of specific facial and lingual nerves creates a more sustained pulsatility activity compared to stimulation of other cranial nerves. Pulsatility of arteries has intrinsic time constraints related to the time for vasodilation/constriction and time to return to baseline (TBL) after electrical stimulation which may affect the pulsatility response. Control of temporal patterning and the stimulation waveform maximizes the physiological response to cerebral pulsatility and its resulting effects on cerebral spinal fluid penetration into the brain parenchyma for a multitude of therapeutic uses including clearing misfolded proteins and/or administered pharmacological agents, diluting endogenous neurochemical concentrations within the brain, and reducing non-synaptic coupling.
    Type: Application
    Filed: July 22, 2020
    Publication date: February 11, 2021
    Inventors: Kip Ludwig, Justin Williams, Angela Williams, Samuel Poore