Abstract: Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2?-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia.

Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.

Abstract: A window security device includes a pull handle, the pull handle defining a tongue slot extending through the pull handle from a top paddle surface to a bottom paddle surface; and a locking bar slidably attached to the pull handle, a locking bar body of the locking bar positioned adjacent to the bottom paddle surface, a tongue of the locking bar extending through the tongue slot.

Abstract: A system and method for forming a strut. A strut comprises a laminated composite tube having a substantially hollow interior and a pair of longitudinal stiffeners attached to opposite sides of the laminated composite tube.

Abstract: A structure comprising a plurality of walls defining a bladder cavity, the bladder cavity comprises an initial cross section size. A first plurality of wave features provided along at least one of the plurality of walls defining the bladder cavity. In one arrangement, the first plurality of wave features allow the structure to expand from the initial cross section size to a second cross section size after the structure becomes inflated during a composite charge cure, the second cross section size larger than the initial cross sectional size.

Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.

Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.

Abstract: Methods of assembling stiffened composite structures are disclosed. Some methods include forming a stiffener assembly by compacting it within a trough formed in a trunnion. A single trunnion may accommodate two or more different types of stiffeners, thereby avoiding the need for multiple sets of tooling. In some methods, a plurality of stiffener segments may be spliced together, thereby avoiding the need to transport and handle an entire stiffener. A vacuum chuck may be utilized in some examples to transfer the stiffener assembly from the trunnion to a transfer tool. The same vacuum chuck may be transferred along with the stiffener assembly on the transfer tool and loaded onto an inner mold line layup mandrel, where the vacuum chuck may be used to compact the stiffener assembly to the inner mold line layup mandrel.

Abstract: A structure comprising a plurality of walls defining a bladder cavity, the bladder cavity comprises an initial cross section size. A first plurality of wave features provided along at least one of the plurality of walls defining the bladder cavity. In one arrangement, the first plurality of wave features allow the structure to expand from the initial cross section size to a second cross section size after the structure becomes inflated during a composite charge cure, the second cross section size larger than the initial cross sectional size.

Abstract: A system and method for forming a strut. A strut comprises a laminated composite tube having a substantially hollow interior and a pair of longitudinal stiffeners attached to opposite sides of the laminated composite tube.

Abstract: A device for compacting a contoured elongate composite layup includes flexible first and second fiber reinforced resin flexible sections flexible along their lengths. The first section is flexible within a first plane and the second section is flexible within the first plane as well as within a second plane.

Abstract: A system and method for forming a strut. A strut comprises a laminated composite tube having a substantially hollow interior and a pair of longitudinal stiffeners attached to opposite sides of the laminated composite tube.

Abstract: A columnar structure comprises a generally hollow laminate core, an outer composite skin, and a sleeve-like reinforcement. The sleeve-like reinforcement surrounds the laminate core and is sandwiched between the laminate core and the outer composite skin for reacting compressive loads imposed on the columnar structure.

Abstract: A window security device includes a pull handle, the pull handle defining a tongue slot extending through the pull handle from a top paddle surface to a bottom paddle surface; and a locking bar slidably attached to the pull handle, a locking bar body of the locking bar positioned adjacent to the bottom paddle surface, a tongue of the locking bar extending through the tongue slot.

Abstract: An uncured composite member is formed over a mandrel having a contour using a flexible compactor. Forming is performed outwardly from the apex of the contour.

Abstract: The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.

Abstract: A device for compacting a contoured elongate composite layup includes flexible first and second fiber reinforced resin flexible sections flexible along their lengths. The first section is flexible within a first plane and the second section is flexible within the first plane as well as within a second plane. The second section includes flexible joints reinforced by a spine.

Abstract: Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2?-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia.

Abstract: A device for compacting a contoured elongate composite layup includes flexible first and second fiber reinforced resin flexible sections flexible along their lengths. The first section is flexible within a first plane and the second section is flexible within the first plane as well as within a second plane. The second section includes flexible joints reinforced by a spine.

Abstract: Windows and secure corner assemblies are generally described. The windows may include a sash having stiles arranged on vertical sides thereof and rails arranged on horizontal sides thereof. Primary reinforcement members may be arranged within the stiles. Secure corner assemblies may be configured to be arranged within corners of the sash formed by intersections of the stiles and the rails. The secure corner assemblies may include at least one secondary reinforcement member arranged on an external surface of one of the rails, such as a top rail. A tilt mechanism may be configured to be coupled to a primary reinforcement member and the at least one secondary reinforcement member, thereby providing a continuous reinforcement connection around the window sash. Vinyl windows using corner assemblies according to some embodiments may have increased pressure ratings compared to vinyl windows that do not include such corner assemblies.