Abstract: Provided herein are lipidic furan, pyrrole, and thiophene compounds, compositions, and methods using such compounds and compositions for the treatment of atrophic vaginitis. Specifically, the invention includes administering an effective amount of a compound of Formula I, I?, or I?, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from atrophic vaginitis.

Abstract: In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the saphenous and/or tibial nerves. The stimulation could include burst stimulation, and involve receiving an input relating to autonomic nervous system activity of the patient, and modifying at least one brain or spinal cord autonomic feedback loop relating to bladder function based on the input to balance parasympathetic and sympathetic nervous system activity of the patient.

Abstract: Synchronizing operation between a digital radiographic detector's integration periods and an x-ray generator's x-ray pulse rate by transmitting a frame rate to the detector and the generator. In a first mode, the detector monitors one or more pixels to detect an x-ray pulse. The firing time of the detected x-ray pulse relative to an internal clock of the detector is used to synchronize the detector's integration periods with the pulse rate of the x-ray generator based on the transmitted frame rate and the detected firing time of the x-ray pulses. Successive pulses may also be used to determine a frame rate without prior transmission thereof.

Abstract: A system and method for providing therapy to a patient can include a monitoring unit and a therapy unit. The monitoring unit can have a user interface and one or more sensors to measure patient data. The therapy unit can have a stimulator for generating electrical stimulation and a microcontroller for controlling the generation of the electrical stimulation based on the measured patient data.

Abstract: A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator can have electrodes that are placed circumferentially around the patient's wrist or arm. Specific nerves in the wrist or arm can be targeted by appropriate spacing of the electrodes. Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate tremor feedback, external data, predictive adaptation, and long-term monitoring data.

Abstract: Provided herein are lipidic furan, pyrrole, and thiophene compounds, compositions, and methods using such compounds and compositions for the treatment of atrophic vaginitis. Specifically, the invention includes administering an effective amount of a compound of Formula I, I?, or I?, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from atrophic vaginitis.

Abstract: A digital radiographic detector detects a first mode signal and dispositions a received digital image according to a procedure associated with the first mode signal. A second mode signal results in dispositioning a second received digital image according to a second image disposition procedure. The detector determines the first mode or second mode based on the signal's pulse width, a number and timing of rising edges (peaks), a digital code, a voltage level, or a combination thereof.

Abstract: A method for fluoroscopy energizes a radiation source to form a scout image on a detector and processes the scout image to determine and report a radiation field position with respect to a predetermined zone of the detector. The radiation source is energized for fluoroscopic imaging of a subject when the reported radiation field position is fully within the predetermined zone.

Abstract: A sterilization system consisting of a mobile emitter, a sensing subsystem and a data logging subsystem is described. The emitter has one or more UV emitting lamps or devices. The sensing system comprises at least one remote UV sensor and at least one door sensor. The door sensor comprises a safety shut off door detector and may contain an emergency stop detector and arming detector to protect people from being exposed to UV energy. The system has a remote control for starting, stopping and setting system parameters which include but are not limited to: treatment time, dosage, room size, room number, unit number, floor, facility name, operator name, operator identification number, password, default dosage values, dosage, and patient identification number. The number of treatments per unit of time can be maximized because of the use of incident light measurement.

Abstract: A depth-first walk of a tree structure is performed to populate nodes of the tree structure with corresponding merged tiles of a merged data pyramid to be generated during the walk from source tiles. At a first visit of a target node, a source tile from a first source data layer corresponding to the target is fetched and stored in memory as a first source-derived tile corresponding to the target. At a last visit of the target, a resampling on source-derived tiles from a second source data layer stored in memory corresponding to children nodes of the target node is performed to generate and store in memory a second source-derived tile corresponding to the target node. Also, at the last visit of the target, at least the first and second source-derived tiles are merged to generate a merged tile of the merged data pyramid corresponding to the target.

Abstract: Disclosed herein are systems, devices, and methods for peripheral nerve stimulation, particularly for treating tremor. The nerve stimulation may be accomplished by a wearable nerve stimulation device, such as a band configured to be worn on the wrist or other body part. The device can accomplish targeted nerve stimulation using circumferentially spaced electrodes. In some embodiments, the device may use only the same number of electrodes as the number of nerves that are to be stimulated. A biphasic charge-balanced waveform may be used to selectively stimulate a nerve near one of the activated electrodes but not to stimulate the nerve near the other activated electrode. The device may use dry electrodes for long-term, repeated use. The dry electrodes may include a conductive base layer and a polymeric, plastic or rubber skin contact layer comprising a conductive filler. The filler may be a powder, fiber, conductive coating, etc.

Abstract: A depth-first walk of a tree structure is performed to populate nodes of the tree structure with corresponding merged tiles of a merged data pyramid to be generated during the walk from source tiles. At a first visit of a target node, a source tile from a first source data layer corresponding to the target is fetched and stored in memory as a first source-derived tile corresponding to the target. At a last visit of the target, a resampling on source-derived tiles from a second source data layer stored in memory corresponding to children nodes of the target node is performed to generate and store in memory a second source-derived tile corresponding to the target node. Also, at the last visit of the target, at least the first and second source-derived tiles are merged to generate a merged tile of the merged data pyramid corresponding to the target.

Abstract: Systems, devices, and methods for stimulating peripheral nerves in the fingers or hand to treat tremor are described. For example, a wearable ring device for delivering electrical stimulation to sensory nerves in a patient's finger can include an annular ring having a plurality of electrodes and a detachable unit having a power source and a pulse generator.

Abstract: A system and method for providing therapy to a patient can include a monitoring unit and a therapy unit. The monitoring unit can have a user interface and one or more sensors to measure patient data. The therapy unit can have a stimulator for generating electrical stimulation and a microcontroller for controlling the generation of the electrical stimulation based on the measured patient data.

Abstract: A method for fluoroscopy energizes a radiation source to form a scout image on a detector and processes the scout image to determine and report a radiation field position with respect to a predetermined zone of the detector. The radiation source is energized for fluoroscopic imaging of a subject when the reported radiation field position is fully within the predetermined zone.

Abstract: A remote robot monitoring system. It has a remote data server; a remote user interface; a robot with a general-purpose in processor programmable by program-code instructions; and computer-readable memory in communication with and accessible by the general-purpose processor, including: robot-task program code comprising instructions for execution by the processor to control functioning of the robot to perform a task; and robot monitoring program code distinct from the robot-task program code, wherein the robot monitoring program code is configured as a plug-in to the robot-task program code, the robot monitoring program code including: a data reception module to receive robot performance data; and remote data transmission program code to establish a connection with the remote data server to receive the robot performance data and transmit robot monitoring data according to the robot performance data to the remote data server.

Abstract: A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator can have electrodes that are placed circumferentially around the patient's wrist or arm. Specific nerves in the wrist or arm can be targeted by appropriate spacing of the electrodes. Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate tremor feedback, external data, predictive adaptation, and long-term monitoring data.

Abstract: A slot scanning system and method for imaging a patient. The method comprises: providing a source of x-ray radiation, directed toward a subject; providing a large flat portable freely-positionable non-tethered stationary digital detector spaced from the source and positioned to receive the x-ray radiation; providing a slotted collimator intermediate the x-ray source and digital detector; and generating a digital x-ray image of the patient by combining a captured plurality of line images.

Abstract: Disclosed are improved LiDAR systems methods employing late-lock Geiger mode detection. In sharp contrast to the prior art, a late-lock Geiger mode detection system and/or method utilizes a pulsed laser and asynchronous avalanche photodiodes with a holdoff time between photodiode arm pulses that are substantially equal to—but slightly less than—the laser pulse period. Preferably, such difference between the holdoff time and the pulse period is <10 nsec.