Abstract: The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures. The hydrogel compositions can also include various stabilizing polymers and active agents to further aid their use in the body.

Abstract: The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures. The hydrogel compositions can also include various stabilizing polymers and active agents to further aid their use in the body.

Abstract: The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having a graft material and a stent structure attached with a suture, or a seam formed by a suture, where the suture has a coating that expands upon exposure to body fluids. The expansion allows for the coating to fill suture holes in the graft material so as to reduce or eliminate endoleaks.

Abstract: The techniques of this disclosure generally relate to applying an armor coating to a graft material. The armor coating is armor, impermeable to fluid, and elastic. The armor coating seals openings within the graft material eliminating passage of fluid through the graft material.

Abstract: The techniques of this disclosure generally relate to a prosthesis including framed biodegradable yarn graft material having a frame and biodegradable yarns combined with the frame. The biodegradable yarns seal tissue integration openings within the frame. The frame provides long term mechanical strength while the biodegradable yarns provide acute strength and impermeability to prevent endoleaks. As the biodegradable yarns degrade, the drop in textile density creates tissue integration openings, through which tissue grows. The integrate of tissue into the framed biodegradable yarn graft material provides biological fixation of the prosthesis in vessels and prevents endoleaks and migration of the prosthesis.

Abstract: The techniques of this disclosure generally relate to prosthesis formed from a biodegradable composite yarn. The biodegradable composite yarn includes a permanent core and a biodegradable shell. The biodegradable shell slowly dissolves over a period of time when placed in a vessel. As the biodegradable shell dissolves, openings are created in the prosthesis that are filled with tissue from the vessel wall of the vessel. The integration of the tissue into the prosthesis provides biological fixation of prosthesis in the vessel and prevents endoleaks and migration of prosthesis.

Abstract: A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.

Abstract: A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.

Abstract: A handle component of a medical device is disclosed for delivering a material to an enclosed cavity or space. The handle component includes a self-contained mechanism for holding the material and for providing or releasing the material to the enclosed cavity. The handle component also includes a pressure relief valve in fluid communication with the mechanism and the enclosed cavity. The pressure relief valve is configured to indicate when delivery of the material to the enclosed cavity reaches a preselected or set pressure and to thereby assure precise filling of the enclosed cavity with the material.

Abstract: The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having a graft material and a stent structure attached with a suture, or a seam formed by a suture, where the suture has a coating that expands upon exposure to body fluids. The expansion allows for the coating to fill suture holes in the graft material so as to reduce or eliminate endoleaks.

Abstract: The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures. The hydrogel compositions can also include various stabilizing polymers and active agents to further aid their use in the body.

Abstract: Endoluminal prosthetic devices having fluid-absorbable compositions for repair of vascular tissue defects, such as an aneurysm or dissection, are disclosed herein. A prosthesis for repairing an opening or cavity within a target vessel region configured in accordance herewith includes a tubular body sized to substantially cover the opening or cavity, and having channels formed in a wall thereof. The channels can include a fluid-absorbable composition deposited therein and which is configured to absorb fluid (e.g., blood) and swell within the channels, thereby providing radial expansion of the tubular body in situ.

Abstract: A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.

Abstract: A handle component of a medical device is disclosed for delivering a material to an enclosed cavity or space. The handle component includes a self-contained mechanism for holding the material and for providing or releasing the material to the enclosed cavity. The handle component also includes a pressure relief valve in fluid communication with the mechanism and the enclosed cavity. The pressure relief valve is configured to indicate when delivery of the material to the enclosed cavity reaches a preselected or set pressure and to thereby assure precise filling of the enclosed cavity with the material.

Abstract: A variable zone high metal to vessel ratio stent includes a proximal high metal to vessel ratio zone, a central low metal to vessel ratio zone, and a distal high metal to vessel ratio zone. The proximal high metal to vessel ratio zone is deployed with fixation and sealing to healthy tissue of a main vessel superior to branch vessels and an aneurysm. The central low metal to vessel ratio zone is deployed directly on ostai of the branch vessels. However, as the central low metal to vessel ratio zone is highly permeable, blood flows from the main vessel through the central low metal to vessel ratio zone and into branch vessels.

Abstract: In embodiments, medical devices have a surface that includes a catalytic material, and a non-fouling material attached to the surface. The non-fouling material can be released from the surface, for example, by cleavage of a bond connecting the material to the surface. The bond can be a chemical bond, such as a covalent bond.

Abstract: A method includes covering ostai of branch vessels emanating from a main vessel and an aneurysm with a high metal to vessel ratio stent. A metal to vessel ratio of the high metal to vessel ratio stent is sufficiently high to encourage tissue ingrowth around the high metal to vessel ratio stent yet is sufficiently low to ensure perfusion of the branch vessels through the high metal to vessel ratio stent. The ingrowth of tissue provides secure fixation and sealing of the high metal to vessel ratio stent to the main vessel and remodels and essentially eliminates the aneurysm. Further, as the entire high metal to vessel ratio stent is permeably, the high metal to vessel ratio stent is deployed without having to rotationally position the high metal to vessel ratio stent.

Abstract: A method includes covering ostai of branch vessels emanating from a main vessel and an aneurysm with an integrated mesh high metal to vessel ratio stent. The integrated mesh high metal to vessel ratio stent includes serpentine rings integrated with an integrated mesh having holes formed therein. A metal to vessel ratio of the integrated mesh high metal to vessel ratio stent is sufficiently high to encourage tissue ingrowth around the integrated mesh high metal to vessel ratio stent yet is sufficiently low to ensure perfusion of the branch vessels through the integrated mesh high metal to vessel ratio stent.

Abstract: A method includes covering ostai of branch vessels emanating from a main vessel and an aneurysm with an integrated mesh high metal to vessel ratio stent. The integrated mesh high metal to vessel ratio stent includes serpentine rings integrated with an integrated mesh having holes formed therein. A metal to vessel ratio of the integrated mesh high metal to vessel ratio stent is sufficiently high to encourage tissue ingrowth around the integrated mesh high metal to vessel ratio stent yet is sufficiently low to ensure perfusion of the branch vessels through the integrated mesh high metal to vessel ratio stent.

Abstract: A variable zone high metal to vessel ratio stent includes a proximal high metal to vessel ratio zone, a central low metal to vessel ratio zone, and a distal high metal to vessel ratio zone. The proximal high metal to vessel ratio zone is deployed with fixation and sealing to healthy tissue of a main vessel superior to branch vessels and an aneurysm. The central low metal to vessel ratio zone is deployed directly on ostai of the branch vessels. However, as the central low metal to vessel ratio zone is highly permeable, blood flows from the main vessel through the central low metal to vessel ratio zone and into branch vessels.