Abstract: Apparatus and associated methods relate to multi-faceted implantable physiological interface system including an array of panels each panel including a substrate defining opposing first and second sides, a bioprocessor supported on the first side and operatively coupled to an electrode disposed on the second side. In an illustrative example, the substrate of each of the panels joins the substrate of at least one other adjacent panel such that the array of panels collectively define an outer enclosure having an internal volume configured to house one or more internal components. The internal components, may, for example, include sensors, actuators, therapeutic components, communication modules, data stores, security modules, thermal management units, and power sources. Various embodiments may advantageously provide multi-faceted, modular, adaptive physiological interfaces enabling precise monitoring, stimulation, and therapeutic interventions while dynamically conforming to a target environment.

Abstract: Apparatus and associated methods relate to multi-modal fluid management module (MMFMM) including a conduit in fluid communication with a cerebrospinal fluid (CSF) filled region of the brain, two or more electrodes in electrical contact with a region of a brain or dura, and at least one optical emitter configured to emit light to a target spot within a brain. The light may, for example, include a wavelength suitable for optogenetics. The MMFMM may, for example, include at least one pressure sensor mechanically coupled to the conduit configured to measure intracranial pressure. In an illustrative example, the MMFMM may, for example, include a valve configured to control fluid flow in and out of the conduit. Various embodiments may advantageously provide a system to monitor and control intracranial pressure and monitor and stimulate electrical activity of the brain (e.g., brain activity).

Abstract: Apparatus and associated methods relate to a multimodal signal management system (MMSMS) that includes two or more electrodes, and a cerebrospinal fluid pressure (CSF) monitor enclosed within a housing implanted in the brain. In an illustrative example, the MMSMS, may, for example, include a conduit configured to provide fluid communication between the CSF-containing region in the brain and a remote location. Various embodiments may advantageously provide therapeutical CSF draining while monitoring electroencephalogram (EEG) and CSF pressure waveform information.

Abstract: Apparatus and associated methods relate to automatically generate an immersive digital prehabilitation package (IDPP) to a user device based on a dynamically determined fitness metric associated with the user device. In an illustrative example, an adaptive personalized prehabilitation system (APPS) may, in response to an activation signal, retrieve a fitness metric and a prehabilitation experience associated with a user associated with the user device. The APPS, for example, may determine a mental fitness and a physical fitness of the user based on the fitness metric. For example, the APPS may adaptively generate a target state based on the fitness of the user and the prehabilitation experience, and the current state of the user. The APPS, for example, may generate the IDPP configured to induce the user to progress from a current state to the adaptive target state. Various embodiments may advantageously increase prehabilitation efficiency and/or reduce post-experience interventions.

Abstract: Apparatus and associated methods relate to smart shunt systems. In an illustrative example, a cerebrospinal fluid (CSF) shunt system includes an interface module and conduit(s) configured to provide selective fluid communication between a brain ventricle(s) and at least one reservoir. The interface module may be operably coupled to one or more control module(s). The control module(s) may, for example, be operably coupled to one or more actuator(s) and/or sensor(s) (e.g., in the interface module(s), external to the interface module(s)). The control module(s) may, for example, selectively operate one or more of the actuator(s) as a function of input received from one or more of the sensors based on one or more predetermined control profile(s). Various embodiments may advantageously dynamically (e.g., automatically) control physiological attributes (e.g., CSF attributes).

Abstract: A vacuum fixation device to provide semi-rigid head fixation during medical imaging and medical procedures/operations of the face and head is disclosed. The invention addresses the problem of patient movement during medical/imaging procedures. The invention is a vacuum fixation bag that is designed to provide maximum surface area contact with the subject's head creating semi-rigid immobilization while allowing access to the face and cranial vault. The invention is comprised of an airtight flexible bag containing an effective amount of Styrofoam beads and a closable port providing semi-rigid fixation. The bag is especially configured to provide stabilization to the neck, the under surface of the mandible, the lateral head around the peri-auricular surfaces, and the forehead. The current invention is provided as a sterile, single use item that provides semi-rigid head fixation during medical imaging and medical procedures/operations of the face and head.

Abstract: A vacuum fixation device to provide semi-rigid head fixation during medical imaging and medical procedures/operations of the face and head is disclosed. The invention addresses the problem of patient movement during medical/imaging procedures. The invention is a vacuum fixation bag that is designed to provide maximum surface area contact with the subject's head creating semi-rigid immobilization while allowing access to the face and cranial vault. The invention is comprised of an airtight flexible bag containing an effective amount of Styrofoam beads and a closable port providing semi-rigid fixation. The bag is especially configured to provide stabilization to the neck, the under surface of the mandible, the lateral head around the peri-auricular surfaces, and the forehead. The current invention is provided as a sterile, single use item that provides semi-rigid head fixation during medical imaging and medical procedures/operations of the face and head.