Abstract: A system and a method of providing electromagnetic compatibility (EMC) protection. A removable component is inserted into an end product. The removable component includes a retractable EMC protection apparatus. In response to the insertion of the removable component a shape memory alloy on the EMC protection apparatus is heated to a temperature above the activation temperature of the shape memory alloy. The shape memory alloy then changes from a first shape to a second shape in response to the heating. In response to the change in the shape of the shape memory alloy an EMC protection component of the EMC protection apparatus is inserted into an enclosure opening of the removable component.

Abstract: The present disclosure relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a subject. Accordingly, in certain non-limiting embodiments, the present disclosure provides for methods, compositions and kits for a companion diagnostic for CDK4 inhibitors, and in particular, for the use of the colocalization of Enigma and CDH18 biomarkers to foci within the cancer for determining whether the cancer can be successfully treated by CDK4 inhibition.

Abstract: The present invention relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a subject. Accordingly, in certain non-limiting embodiments, the present invention provides for methods, compositions and kits for a companion diagnostic for CDK4 inhibitors, and in particular, for the use of the colocalization of Enigma and CDH18 biomarkers to foci within the cancer for determining whether the cancer can be successfully treated by CDK4 inhibition.

Abstract: The present invention relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a subject. It is based, at least in part, on the discovery that cancer treatment with a CDK4 inhibitor is more effective where treated cancer cells undergo cellular senescence rather than a transient cell cycle arrest, where cellular senescence is associated with decreased MDM2 protein level. Accordingly, in non-limiting embodiments, the present invention provides for methods, compositions, and kits for a companion diagnostic for CDK4 inhibitors, and in particular, to the use of MDM2 expression as a biomarker for the likelihood that a cancer can be successfully treated by CDK4 inhibition.

Abstract: The present invention relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a subject. It is based, at least in part, on the discovery that cancer cells expressing ATRX prior to treatment are more likely to undergo cellular senescence in response to treatment with a CDK4 inhibitor. It is also based, at least in part, on the discovery that ATRX is phosphorylated in cancer cells that are not as responsive to CDK4 inhibitor therapy. Accordingly, in non-limiting embodiments, the present invention provides for methods, compositions, and kits for a companion diagnostic for CDK4 inhibitors, and in particular, to the use of ATRX expression as a biomarker for determining the likelihood that a cancer can be successfully and/or unsuccessfully treated by CDK4 inhibition.

Abstract: The present invention relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a subject. It is based, at least in part, on the discovery that cancer treatment with a CDK4 inhibitor is more effective where treated cancer cells undergo cellular senescence rather than a transient cell cycle arrest, where cellular senescence is associated with decreased MDM2 protein level. Accordingly, in non-limiting embodiments, the present invention provides for methods, compositions, and kits for a companion diagnostic for CDK4 inhibitors, and in particular, to the use of MDM2 expression as a biomarker for the likelihood that a cancer can be successfully treated by CDK4 inhibition.

Abstract: Techniques for corrected nuclear magnetic resonance (NMR) data include applying a presaturation radio frequency (RF) magnetic field different from a fat molecule resonance for a particular time to a target tissue; and applying a first measurement RF magnetic field within a first time after the particular time. Correction nuclear magnetic resonance (NMR) data from the target tissue is determined based on first NMR data received in response to applying the first measurement RF magnetic field. In some embodiments, a second measurement RF magnetic field is also applied in a second time different from both the particular time and the first time. Corrected NMR data is determined by subtracting the correction NMR data from second NMR data received in response to applying the second measurement RF magnetic field. Among other applications, these techniques allow distinguishing either fat or proteins in edemas, or both, from proteins in other tissues.

Abstract: Techniques for corrected nuclear magnetic resonance (NMR) data include applying a presaturation radio frequency (RF) magnetic field different from a fat molecule resonance for a particular time to a target tissue; and applying a first measurement RF magnetic field within a first time after the particular time. Correction nuclear magnetic resonance (NMR) data from the target tissue is determined based on first NMR data received in response to applying the first measurement RF magnetic field. In some embodiments, a second measurement RF magnetic field is also applied in a second time different from both the particular time and the first time. Corrected NMR data is determined by subtracting the correction NMR data from second NMR data received in response to applying the second measurement RF magnetic field. Among other applications, these techniques allow distinguishing either fat or proteins in edemas, or both, from proteins in other tissues.

Abstract: The present invention is based on the finding that activation of PPAR? plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR? agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proliferation of such cells.

Abstract: The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.

Abstract: The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.

Abstract: The bandwidth of a two-way broadband signal transmission system is expanded by frequency stacking shared band signals. The up conversion (stacking) and down conversion (destacking) systems utilize matched filters, preferably in a multiplexer configuration, which are directly connected, without a combiner, to output the stacked frequency signal in the case of the up conversion system, and without a splitter to separate the frequency stacked signals in the down conversion system. A single base local oscillator signal is used to generate all of the local oscillator signals needed in the system for up and down conversion.

Abstract: Broadband RF circuits in which multiple circuit elements are interconnected by microstrips arranged in regular patterns on printed circuit boards have the microstrips laid out in randomly meandering paths such that adjacent paths are non-parallel and non-symmetrical about a common axis, to increase the isolation between adjacent signal paths in broadband splitters, combiners, routers, switching systems and control systems operating up to the GHz frequency range.

Abstract: An orthopaedic brace for a joint includes a support mechanism attached to limb members on either side of the joint for providing support to the joint and for permitting a predetermined range of movement of the joint. The support mechanism defines a void space substantially surrounding the joint between the support mechanism and the joint. An inflatable air bag that preferably includes several air cells substantially surrounds the joint in the void space. At least one sensor attached to the support mechanism provides a trigger signal in response to a predetermined, potentially injurious condition, such as a severe force, stress, strain or acceleration. An inflation mechanism operatively connected to the air bag and the sensor inflates the air bag in response to the trigger signal, thereby providing additional support to the joint before the joint is injured.

Abstract: The basic element of a modular, bidirectional broadband programmable switch system is a switch module having a thin rectangular housing with a single first connector preferably in the center of an elongated rear face and n second connectors equally spaced along the elongated front face. Broadband switches within the module selectively connect the single first connector with any one of the second connectors to provide an n.times.1 or 1.times.n switch. Up to n of the switch modules can be stacked side-by-side with an additional module extending transversely with its n second connectors connected to the first connectors on the stacked modules to provide an n.sup.2 .times.1 or 1.times.n.sup.2 switch. The first connectors on the additional modules of two such stacks can be connected to provide an n.sup.2.times.n.sup.2 switch.

Abstract: A conventional STOP/SLOW traffic control sign mounted on a pole is supported and remotely operated by a portable stand having a tubular support mounted on a foldable frame which also carries a remotely controlled drive assembly so that the sign can be operated at a safe distance even by a person with disabilities.

Abstract: A knee brace has an adjustable rigid posterior strut with an arcuate member which extends through the popliteal space behind the knee joint and is made of two halves which can be extended or retracted axially or rotated with respect to one another. Terminal portions of the strut, to which supports secured to the leg and thigh are hinged, are adjustably secured by ball and socket connections to mounting members which in turn are adjustably attached to the arcuate member by stems which telescope into and rotate within bores in the ends of the two halves of the arcuate member. With these adjustments the components of the posterior strut can be locked in a myriad of configurations to accommodate for various sizes and deformities of protected joints.

Abstract: A knee brace has a rigid posterior strut behind the knee joint in the popliteal area with terminal portions adjacent, but spaced from the lateral and medial sides of the knee. A prophylactic embodiment of the invention has a lateral inferior rigid support member pivoted on the lateral terminal portion of the strut and secured to the leg, and a medial superior rigid support member pivoted on the medial terminal portion of the strut and secured to the thigh. Stiff anterior, generally triangular, cuff members each have one edge secured to one of the rigid support members and an opposite vertex detachably, pivotally secured to the opposite terminal portion of the strut. A functional brace in accordance with the invention has both lateral and medial rigid support members pivoted on the terminal portions on the posterior strut, additional stiff anterior generally triangular cuffs criss-crossing above and below the knee join and stiff posterior cuffs between the pairs of rigid support members.

Abstract: Nematodes are controlled in host animals by contacting the animal or its environment with a bacterial toxin produced by strains of Bacillus laterosporus, the toxin being capable of inhibiting nematode egg hatchability and/or larval development.

Abstract: A support for a keyboard for a computer resting on spaced apart feet on a narrow support surface includes two articulated elongated members which are spaced apart laterally the distance between the feet on the computer by cross-braces. The first end sections of the elongated members are placed on the support surface under the spaced apart feet of the computer to cantilever the middle sections and second end sections out over the edge of the support surface with the middle sections extending generally downward adjacent the edge of the support surface and the second end sections extending generally laterally outward from the middle sections to form spaced part supports for the keyboard.