Patents by Inventor Samuel Slone

Samuel Slone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the treatment of cardiac hypertrophy
    Patent number: 10933135
    Abstract: Methods for the treatment of cardiac hypertrophy are described. Additionally, the presently disclosed subject matter relates to the use of small molecule compounds for the inhibition of Human antigen R (HuR)-mRNA interaction, and more particularly for the reduction of nuclear factor of activated T cells (NFAT) transcriptional activity. Novel methods of screening for small molecule compounds for inhibition of RNA binding proteins interaction with their target RNA (such as HuR-mRNA interactions) or for inhibition of DNA binding proteins to their target DNA are also described.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: March 2, 2021
    Assignee: University of Cincinnati
    Inventors: Michael Tranter, Sarah Anthony, Samuel Slone
  • METHODS FOR THE TREATMENT OF CARDIAC HYPERTROPHY
    Publication number: 20190117772
    Abstract: Methods for the treatment of cardiac hypertrophy are described. Additionally, the presently disclosed subject matter relates to the use of small molecule compounds for the inhibition of Human antigen R (HuR)-mRNA interaction, and more particularly for the reduction nuclear factor of activated T cells (NFAT) transcriptional activity. Novel methods of screening for small molecule compounds for inhibition of RNA binding proteins interaction with their target RNA (such as HuR-mRNA interactions) or for inhibition of DNA binding proteins to their target DNA are also described.
    Type: Application
    Filed: April 5, 2017
    Publication date: April 25, 2019
    Inventors: Michael Tranter, Sarah Anthony, Samuel Slone, Jie He, George Yoshida, Andrew Gabanic