Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: A device for treating a tissue opening includes a proximal portion including an elongated flexible member, a capsule releasably coupled to a distal end of the flexible member and including a lumen extending therethrough and a clip including a pair of arms movably housed within the capsule. A suture extending along a first one of the pair of arms and including a loop at a distal end thereof extending across an opening extending through the first one of the pair of arms. A suture grabbing element extending laterally from a second one of the pair of arms and including a hook so that, when the pair of arms are moved toward a closed configuration, the hook extends through the opening to grab the loop and draw the distal end of the suture from the first one of the pair of arms toward the second one of the pair of arms.

Abstract: Disclosed herein are methods and systems for generating a merged dataset, comprising: accessing data comprising a core dataset and an additional dataset; identifying a plurality of common attributes between the core dataset and the additional dataset; determining a plurality of similarity scores between an inquiring entity in the core dataset and a plurality of candidate entities in the additional dataset, including, for each candidate entity of the plurality of candidate entities: calculating a similarity score for the candidate entity based at least in part on a distance-based score and a weight influence score; selecting one or more matches for the inquiring entity in the core dataset from the plurality of candidate entities in the additional dataset based at least in part on the plurality of similarity scores; and generating the merged dataset by adding the one or more selected matches for the inquiring entity to the core dataset.

Abstract: Provided herein is a method for sequence analysis that comprises analyzing PCR reactions that each contain different portions of the same sample, wherein at least some of the primer pairs are in more than one PCR reaction and at least one of the PCR reactions contains some but not all of the primer pairs of the other reaction(s).

Abstract: A method includes receiving a series of writes that each requests respective data to be stored at a database. For each respective write, the method includes storing the respective data in a first buffer associated with a first data streaming application and a second buffer associated with a second data streaming application. The method includes transmitting the respective data to the database. The method includes receiving, from the database, confirmation that the respective data of the respective write has been committed to the database. The confirmation includes an order indicator indicating an order the respective data of the respective write was committed to the database relative to other writes in the series of writes. In response to receiving the confirmation, the method includes sending the respective data from the first buffer to the first data streaming application and from the second buffer to the second data streaming application.

Abstract: Systems and methods are described for managing inventory stock for variable weighted and variable priced agricultural products. A system includes a memory device storing a data structure that relates a plurality of available base unit values and a plurality of available base unit measurement types to each type of agricultural product type. The system also includes an interface controller configured to provide an interactive interface for a vendor. The interactive interface includes an agricultural product type field, a base unit values field, and a base unit measurement type field. The system further includes a processor that creates a product purchase interactive interface using a selected agricultural product type, a selected base unit value, and a selected base unit measurement type to enable a buyer to purchase the agricultural product type in one or more increments of the base unit value at the base unit measurement type.

Abstract: An apparatus for monitoring blood oxygen saturation of a subject is provided. The apparatus includes a unit configured for wearing on the subject's upper arm, the unit comprising first and second light sources configured to emit light of first and second wavelengths and a photodetector configured to detect light of the first and second wavelengths, where the light sources are arranged to direct light into the upper arm and the photodetector is arranged to detect light reflected from within the upper arm.

Abstract: A method for making a seat includes the step of overmolding a carrier onto a fabric seat surface. The fabric surface is formed from a woven fabric material having heating element fibers. The heating element fibers are placed in contact with a conductor. The carrier and the conductor are then positioned into a frame.

Abstract: A seat assembly includes a fabric component with a seat surface and with an interior segment directly attached to the fabric component. The interior segment extends from an exterior segment that has a greater flexural resistance than the interior segment.

Abstract: The present disclosure provides a rotational spring dampener including a core having an opening therethrough, a first solid component having a first set of bosses, a second solid component having a second set of bosses, and a tensile member positioned between the first solid component and the second solid component. The tensile member is composed of a solid silicon polymer.

Abstract: A seat assembly includes a fabric component having a seat surface and a frame including an interior segment directly attached to the fabric component. The interior segment extends from an exterior segment that has a greater flexural resistance than the interior segment.

Abstract: A vehicle seat includes a support structure, a seat surface (14) and a molded polymeric frame (18). The frame has an edge region and the seat surface (14) is mounted to the frame (18) and the frame is mounted to the support structure. At least a portion of the edge region is flexible.

Abstract: A suspended fabric seat includes a frame, a woven fabric suspended in the frame and a plurality of compression limiters attached to the woven fabric. The woven fabric is formed from monofilament fibers that are oriented in a first direction and textile fibers oriented in a second direction transverse to the first direction. The plurality of compression limiters are oriented in the first direction and are formed from a material compatible with the woven fabric. A method for making the suspended fabric seat is also disclosed.

Abstract: A seat and cooling system for the seat include a porous seat surface, an air spacer disposed on a side of the seat surface that defines an air channel, a substantially air impermeable barrier having an opening therein in communication with the air channel and a blower configured to draw air through the seat surface and from the air channel. Air drawn from around an occupant on the seat surface draws moisture from the occupant, causing moisture to evaporate, to provide a cooling sensation.

Abstract: Disclosed is a method of location identification using a single beacon. The method comprises determining a first distance between a beacon and a first sensor, where the first sensor is embedded in a mobile device. It also includes determining a second distance between the beacon and a second sensor, where the second sensor is embedded in the mobile device. The method also includes defining a vector, where the vector has a magnitude equal to the distance between the first and second sensor, and a direction pointing from the first sensor to the second sensor. The method further includes calculating a plurality of potential locations. The method then determines the actual location.

Abstract: A method for making a seat includes the step of overmolding a carrier onto a fabric seat surface. The fabric surface is formed from a woven fabric material having heating element fibers. The heating element fibers are placed in contact with a conductor. The carrier and the conductor are then positioned into a frame.

Abstract: Disclosed is a method of location identification using a single beacon. The method comprises determining a first distance between a beacon and a first sensor, where the first sensor is embedded in a mobile device. It also includes determining a second distance between the beacon and a second sensor, where the second sensor is embedded in the mobile device. The method also includes defining a vector, where the vector has a magnitude equal to the distance between the first and second sensor, and a direction pointing from the first sensor to the second sensor. The method further includes calculating a plurality of potential locations. The method then determines the actual location.

Abstract: A suspension fabric seat includes a fabric seat surface formed from a woven fabric material having heating element fibers. The heating element fibers are in electrical communication with a conductor. A carrier is overmolded onto the seat surface. The carrier and the conductor are disposed in a frame and a connector is mounted to the frame in electrical communication with the conductor.

Abstract: The present disclosure provides a rotational spring dampener that has a compression limiter, a first disk, and a second disk. The first disk is disposed at a first end of the compression limiter and the second disk is disposed at a second end of the compression limiter, where the second end is opposite the first end. The rotational spring dampener also has a tensile member. The tensile member is connected to the first disk and the second disk.