Patents by Inventor Samuel Strober

Samuel Strober has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR CANCER TREATMENT
    Publication number: 20200164195
    Abstract: Residual, refractory or relapsed cancer is treated by immunostimulation in the presence of allogeneic immune effector cells, optimally in combination with radiation therapy. The methods of the disclosure induce a systemic allogeneic anti-tumor immune response that results in tumor regression in untreated sites of disease, i.e. non-injected, non-irradiated, etc.
    Type: Application
    Filed: December 16, 2019
    Publication date: May 28, 2020
    Inventors: Robert Lowsky, Edgar George Engleman, Samuel Strober
  • Combined organ and hematopoietic cells for transplantation tolerance of grafts
    Patent number: 10603340
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: March 31, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Robert Lowsky
  • Combined organ and hematopoietic cells for transplantation tolerance of HLA mismatched grafts
    Patent number: 10555971
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an HLA mismatched recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: February 11, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Robert Lowsky
  • Methods for cancer treatment
    Patent number: 10549082
    Abstract: Residual, refractory or relapsed cancer is treated by immunostimulation in the presence of allogeneic immune effector cells, optimally in combination with radiation therapy. The methods of the disclosure induce a systemic allogeneic anti-tumor immune response that results in tumor regression in untreated sites of disease, i.e. non-injected, non-irradiated, etc.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: February 4, 2020
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Robert Lowsky, Edgar George Engleman, Samuel Strober
  • COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
    Publication number: 20190358257
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Application
    Filed: July 18, 2019
    Publication date: November 28, 2019
    Inventors: Samuel Strober, Robert Lowsky
  • COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
    Publication number: 20190336528
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Application
    Filed: July 18, 2019
    Publication date: November 7, 2019
    Inventors: Samuel Strober, Robert Lowsky
  • COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
    Publication number: 20190298762
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Application
    Filed: June 20, 2019
    Publication date: October 3, 2019
    Inventors: Samuel Strober, Robert Lowsky
  • TUMOR VACCINATION IN COMBINATION WITH HEMATOPOIETIC CELL TRANSPLANTATION FOR CANCER THERAPY
    Publication number: 20190201514
    Abstract: In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments, the method involves autologous tumor cell vaccination prior to autologous hematopoietic and immune cell transplantation. In another aspect, the present invention provides a method of purifying tumor cells from a subject in preparation for vaccination.
    Type: Application
    Filed: March 21, 2019
    Publication date: July 4, 2019
    Inventors: Samuel Strober, Alexander Filatenkov
  • COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
    Publication number: 20190192562
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Inventors: Samuel Strober, Robert Lowsky
  • COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
    Publication number: 20190192561
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Inventors: Samuel Strober, Robert Lowsky
  • Tumor vaccination in combination with hematopoietic cell transplantation for cancer therapy
    Patent number: 10286049
    Abstract: In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments, the method involves autologous tumor cell vaccination prior to autologous hematopoietic and immune cell transplantation. In another aspect, the present invention provides a method of purifying tumor cells from a subject in preparation for vaccination.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: May 14, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Alexander Filatenkov
  • Combined organ and hematopoietic cells for transplantation tolerance of grafts
    Patent number: 10258648
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: April 16, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Robert Lowsky
  • COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
    Publication number: 20190091262
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Application
    Filed: November 26, 2018
    Publication date: March 28, 2019
    Inventors: Samuel Strober, Robert Lowsky
  • ANTI-TUMOR T CELL IMMUNITY INDUCED BY HIGH DOSE RADIATION
    Publication number: 20190083537
    Abstract: Cancer treatment is provided, by irradiating an individual with a localized, high single dose or short course of doses at a primary tumor site; collecting T cells from the individual after a period of time sufficient activation of an anti-tumor response; treating the individual with an effective dose of dose of chemotherapy; and reintroducing the T cell population back to the individual.
    Type: Application
    Filed: November 28, 2018
    Publication date: March 21, 2019
    Inventors: Samuel Strober, Alexander Filatenkov
  • COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
    Publication number: 20190083530
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Application
    Filed: November 20, 2018
    Publication date: March 21, 2019
    Inventors: Samuel Strober, Robert Lowsky
  • Combined organ and hematopoietic cells for transplantation tolerance of grafts
    Patent number: 10183043
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: January 22, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Robert Lowsky
  • COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF HLA MISMATCHED GRAFTS
    Publication number: 20190000877
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an HLA mismatched recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Application
    Filed: August 22, 2018
    Publication date: January 3, 2019
    Inventors: Samuel Strober, Robert Lowsky
  • Anti-tumor T cell immunity induced by high dose radiation
    Patent number: 10166256
    Abstract: Cancer treatment is provided, by irradiating an individual with a localized, high single dose or short course of doses at a primary tumor site; collecting T cells from the individual after a period of time sufficient activation of an anti-tumor response; treating the individual with an effective dose of dose of chemotherapy; and reintroducing the T cell population back to the individual.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: January 1, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Alexander Filatenkov
  • Combined organ and hematopoietic cells for transplantation tolerance of grafts
    Patent number: 10159694
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: December 25, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel Strober, Robert Lowsky
  • COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
    Publication number: 20180344766
    Abstract: Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
    Type: Application
    Filed: August 10, 2018
    Publication date: December 6, 2018
    Inventors: Samuel Strober, Robert Lowsky