Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure is generally directed to Siglec-9 ECDs and Siglec-9 ECD fusion molecules, and methods of treatment using Siglec-9 ECDs and Siglec-9 ECD fusion molecules.

Abstract: A robotic line kitting system is disclosed. In various embodiments, a signal associated with an unsafe condition is received via a communication interface. In response to the signal, a controlled operation to reduce a speed of movement of a robotic instrumentality is performed prior to a safety stop of the robotic instrumentality being triggered.

Abstract: Data indicating a corresponding safety state information indicating an extent to which that operating zone currently is or is not available to the robotic system to perform tasks using one or more robotic instrumentalities associated with a robotic system is used, for each of a plurality of operating zones, to dynamically schedule and perform tasks associated with a higher level objective. The corresponding safety state information associated with the first operating zone indicating one of a plurality of safety states associated with a presence of a human worker in the first operating zone is received from one or more sensors associated with a first operating zone of the plurality of operating zones. Autonomous behavior of the one or more robotic instrumentalities is altered based on the one of the plurality of safety states associated with the presence of the human worker in the first operating zone indicated by the corresponding safety state information.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Exemplary embodiments are disclosed of multiband vehicular antenna assemblies with Global Navigation Satellite System (GNSS) capabilities. In exemplary embodiments, a multiband antenna assembly is operable with more than two satellite navigation system frequencies (e.g., Global Positioning System (GPS), BeiDou Navigation Satellite System (BDS), the Russian Global Navigation Satellite System (GLONASS), etc.). For example, a multiband antenna assembly may include a first patch antenna operable with at least three different satellite navigation system frequencies, e.g., GPS, BeiDou, and GLONASS, etc. The first patch antenna may be stacked on a second patch antenna. The second patch antenna may be operable with other frequencies, such as Satellite Digital Audio Radio Services (SDARS) signals (e.g., Sirius XM, etc.). The antenna assembly may also include a coupler that couples the signals from the feed ports of the first patch antenna.

Abstract: Exemplary embodiments are disclosed of multiband vehicular antenna assemblies with Global Navigation Satellite System (GNSS) capabilities. In exemplary embodiments, a multiband antenna assembly is operable with more than two satellite navigation system frequencies (e.g., Global Positioning System (GPS), BeiDou Navigation Satellite System (BDS), the Russian Global Navigation Satellite System (GLONASS), etc.). For example, a multiband antenna assembly may include a first patch antenna operable with at least three different satellite navigation system frequencies, e.g., GPS, BeiDou, and GLONASS, etc. The first patch antenna may be stacked on a second patch antenna. The second patch antenna may be operable with other frequencies, such as Satellite Digital Audio Radio Services (SDARS) signals (e.g., Sirius XM, etc.). The antenna assembly may also include a coupler that couples the signals from the feed ports of the first patch antenna.

Abstract: In an embodiment, a given user equipment (UE) in a local communication session (e.g., a P2P or ad-hoc session) between multiple UEs is designated to record session data. The given UE records the session data exchanged between the multiple UEs during the local communication session and uploads the recorded session data to a server after the local communication session has terminated. In another embodiment, a session controller (e.g., a remote server or a P2P node) receives multiple media feeds from multiple transmitting UEs, and selectively interlaces subsets of the multiple media feeds into interlaced output feed(s) that are transmitted to target UE(s). The target UE(s) provide feedback which permits the session controller to determine a lowest relevant configuration (LRC) for the target UE(s) that is used to regulate the interlaced output feed(s) transmitted thereto.

Abstract: The disclosed invention relates to expression systems that effect production of a protein in plants that confers resistance to trauma. The expression systems are used to modify plants to improve their resistance to infections and wounding.

Abstract: The disclosed invention relates to expression systems that effect production of a protein in plants that confers resistance to trauma. The expression systems are used to modify plants to improve their resistance to infections and wounding.

Abstract: Enhancing the expression of nucleotide sequences encoding proteins that comprise at least a DnaJ-type J-domain provides tolerance to plants or plant cells against abiotic stress, especially dehydration and salinity stress.

Abstract: Fusion proteins that comprise at least one subunit of glutelin and a desired protein permit enhanced production of the desired protein in a useable form in plants. Such fusion proteins may be used to improve the nutritional value of plants, such as rice, by enhancing the production of specific essential amino acids in a useable form.

Abstract: Disclosed is an isolated protein from the Chinese medicinal herb, Yuzhu, Polygonatum odoratum (Liliaceae). The protein disclosed is an effective agent showing potent antiviral activities while demonstrating antiproliferative effect on HL-60 leukemia and MCF-7 breast cancer cell lines in vitro. A method of obtaining the target protein and use thereof are also provided.

Abstract: The present invention relates to isolated actin and ?-actin nucleic acid promoter molecules from shrimp; nucleic acid expression cassettes including actin and ?-actin promoter molecules isolated from shrimp; and expression vectors, host cells, and transgenic animals transduced with the isolated actin and ?-actin nucleic acid promoter. Also disclosed are methods for imparting to an animal resistance against a pathogen; regulating growth of an animal; increasing stress tolerance in an animal; and increasing cold tolerance in an animal that involve transforming an animal with a nucleic acid construct including the isolated actin and ?-actin nucleic acid promoter molecules of the present invention. The present invention also relates to isolated nucleic acid molecules encoding for actin and ?-actin proteins or polypeptides, as well as the proteins or polypeptides themselves.

Abstract: Disclosed is a method for identification of key amino acids in plant proteins critical in generating allergenic activity through mapping the epitope(s) harboring human IgE binding activity. The identified epitope (s) are then modified by amino acid substitution preferably by alanine substitution, for reduced or negative IgE-binding activity. A plant gene expression system comprising a DNA construct placed operably under the control of a promoter sequence that confers seed-specific expression is also disclosed for the expression of the modified proteins. The Brazil nut 2S sulfur-rich protein was exemplified. The method disclosed herein is particularly useful for the production of dietary proteins with improved nutritional quality and reduced or negative allergenicity for human and animal consumption through genetic engineering.

Abstract: The present invention is to provide a recombinant construct for transforming a plant comprising a DNA sequence encoding a recombinant human cytokine and a promoter capable of directing the expression of the recombinant human cytokine in the plant. The present invention is also to provide a method for constructing a transgenic plant, comprising the steps of transforming a plant cell with a recombinant construct of the invention, and regenerating the transgenic plant from the plant cell to produce recombinant human cytokine, for example, human granulocyte colony stimulating factor (hG-CSF), in seeds of the transgenic plant. The plant production method of the invention thus has a promising potential to mass-produce some of the most expensive biopharmaceuticals of restricted availability in a much cheaper way, which has high economic value for disease therapy, diagnosis and prevention, and is more accessible to the less affluent countries.