Patents by Inventor Samuel W. Fielden
Samuel W. Fielden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11644520Abstract: Described herein are systems, methods, and computer-readable medium for magnetic resonance (MR) based thermometry. In one aspect, in accordance with one embodiment, a method for magnetic resonance based thermometry includes: acquiring, by a variable flip-angle T1 mapping sequence, MR data in an area of interest of a subject that is heated by the application of focused ultrasound (FUS) to the brain of the subject, where the MR data includes T1 values over time, and where the acquisition of the MR data includes applying an accelerated three-dimensional ultra-short spiral acquisition sequence with a nonselective excitation pulse; and determining, based at least in part on a mathematical relationship established by T1 mapping thermometry, a temperature change in the area of interest over time, and where the temperature change is caused at least in part by a change in the applied FUS.Type: GrantFiled: January 8, 2021Date of Patent: May 9, 2023Assignee: University of Virginia Patent FoundationInventors: Yekaterina K. Gilbo, Helen L. Sporkin, Samuel W. Fielden, John P. Mugler, III, Grady W. Miller, IV, Steven P. Allen, Craig H. Meyer
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Patent number: 11085980Abstract: In one aspect, in accordance with one embodiment, a method includes acquiring magnetic resonance (MR) data corresponding to bone tissue in an area of interest of a subject that is heated from the application of localized energy. The acquiring includes applying a three-dimensional (3D) ultra-short echo time (UTE) spiral acquisition sequence. The method also includes detecting, from the acquired magnetic resonance data, a change in MR response signal due to a change in at least one of relaxation rate and magnetization density caused by heating of the bone tissue; and determining, based at least in part on the change in the MR response signal, that the temperature of the bone tissue has changed.Type: GrantFiled: May 12, 2017Date of Patent: August 10, 2021Assignees: University of Virginia Patent Foundation, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Samuel W. Fielden, John P. Mugler, III, G. Wilson Miller, IV, Kim Butts Pauly, Craig H. Meyer
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Publication number: 20210208225Abstract: Described herein are systems, methods, and computer-readable medium for magnetic resonance (MR) based thermometry. In one aspect, in accordance with one embodiment, a method for magnetic resonance based thermometry includes: acquiring, by a variable flip-angle T1 mapping sequence, MR data in an area of interest of a subject that is heated by the application of focused ultrasound (FUS) to the brain of the subject, where the MR data includes T1 values over time, and where the acquisition of the MR data includes applying an accelerated three-dimensional ultra-short spiral acquisition sequence with a nonselective excitation pulse; and determining, based at least in part on a mathematical relationship established by T1 mapping thermometry, a temperature change in the area of interest over time, and where the temperature change is caused at least in part by a change in the applied FUS.Type: ApplicationFiled: January 8, 2021Publication date: July 8, 2021Inventors: Yekaterina K. Gilbo, Helen L. Sporkin, Samuel W. Fielden, John P. Mugler, III, Grady W. Miller, IV, Steven P. Allen, Craig H. Meyer
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Patent number: 10718837Abstract: Some aspects of the present disclosure relate to ultrashort-echo-time (UTE) imaging. In one embodiment, a method includes acquiring UTE imaging data associated with an area of interest of a subject. The acquiring comprises applying an imaging pulse sequence with a three-dimensional (3D) spiral acquisition and a nonselective excitation pulse. The method also includes reconstructing at least one image of the area of interest from the acquired UTE imaging data.Type: GrantFiled: April 21, 2017Date of Patent: July 21, 2020Assignees: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, SIEMENS HEALTHCARE GMBHInventors: John P. Mugler, III, Samuel W. Fielden, G. Wilson Miller, IV, Craig H. Meyer, Talissa A. Altes, Alto Stemmer, Josef Pfeuffer, Berthold Kiefer
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Patent number: 10557908Abstract: In some aspects, the disclosed technology relates to magnetic field monitoring of spiral echo train imaging. In one embodiment, a method for spiral echo train imaging of an area of interest of a subject includes measuring k-space values and field dynamics corresponding to each echo of a spiral echo pulse train, using a dynamic field camera and a magnetic resonance imaging (MRI) system. The dynamic field camera is configured to measure characteristics of fields generated by the MRI system; the characteristics include at least one imperfection associated with the MRI system. The spiral echo pulse train corresponds to a spiral trajectory scan from the MRI system that obtains magnetic resonance imaging data using a pulse sequence which applies spiral gradients in-plane with through-plane phase encoding.Type: GrantFiled: April 6, 2018Date of Patent: February 11, 2020Assignee: University of Virginia Patent FoundationInventors: Craig H. Meyer, John P. Mugler, III, Samuel W. Fielden, Gudrun Ruyters, Berthold Kiefer, Josef Pfeuffer
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Publication number: 20180292499Abstract: In some aspects, the disclosed technology relates to magnetic field monitoring of spiral echo train imaging. In one embodiment, a method for spiral echo train imaging of an area of interest of a subject includes measuring k-space values and field dynamics corresponding to each echo of a spiral echo pulse train, using a dynamic field camera and a magnetic resonance imaging (MRI) system. The dynamic field camera is configured to measure characteristics of fields generated by the MRI system; the characteristics include at least one imperfection associated with the MRI system. The spiral echo pulse train corresponds to a spiral trajectory scan from the MRI system that obtains magnetic resonance imaging data using a pulse sequence which applies spiral gradients in-plane with through-plane phase encoding.Type: ApplicationFiled: April 6, 2018Publication date: October 11, 2018Inventors: Craig H. Meyer, John P. Mugler, III, Samuel W. Fielden, Gudrun Ruyters, Berthold Kiefer, Josef Pfeuffer
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Patent number: 9874623Abstract: Systems and methods for magnetic resonance imaging (MRI) using side information for improved reconstruction are disclosed. In one aspect, in accordance with one example embodiment, images obtained using heteronuclei, such as Fluorine-19 (19F), can be reconstructed using one or more methods to provide improved resolution and detail. The system can use anatomical proton MRI scans. The system can use multiple smoothing techniques to improve the signal-to-noise ratio (SNR). The system can also use weighted smoothing using information from anatomical proton MRI scans to improve resolution.Type: GrantFiled: April 22, 2013Date of Patent: January 23, 2018Assignee: University of Virginia Patent FoundationInventors: Samuel W. Fielden, Craig H. Meyer
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Publication number: 20170328972Abstract: In one aspect, in accordance with one embodiment, a method includes acquiring magnetic resonance (MR) data corresponding to bone tissue in an area of interest of a subject that is heated from the application of localized energy. The acquiring includes applying a three-dimensional (3D) ultra-short echo time (UTE) spiral acquisition sequence. The method also includes detecting, from the acquired magnetic resonance data, a change in MR response signal due to a change in at least one of relaxation rate and magnetization density caused by heating of the bone tissue; and determining, based at least in part on the change in the MR response signal, that the temperature of the bone tissue has changed.Type: ApplicationFiled: May 12, 2017Publication date: November 16, 2017Inventors: Samuel W. Fielden, John P. Mugler, III, G. Wilson Miller, IV, Kim Butts Pauly, Craig H. Meyer
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Publication number: 20170307705Abstract: Some aspects of the present disclosure relate to ultrashort-echo-time (UTE) imaging. In one embodiment, a method includes acquiring UTE imaging data associated with an area of interest of a subject. The acquiring comprises applying an imaging pulse sequence with a three-dimensional (3D) spiral acquisition and a nonselective excitation pulse. The method also includes reconstructing at least one image of the area of interest from the acquired UTE imaging data.Type: ApplicationFiled: April 21, 2017Publication date: October 26, 2017Inventors: John P. Mugler, III, Samuel W. Fielden, G. Wilson Miller, IV, Craig H. Meyer, Talissa A. Altes, Alto Stemmer, Josef Pfeuffer, Berthold Kiefer
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Patent number: 9651645Abstract: Systems, methods of reducing off-resonance blurring in acquired magnetic resonance imaging data. The method includes acquiring a first set of spiral interleaf data for each of one or more spiral-in/out interleaves by performing a first sampling each of one or more locations in k-space along a first redundant spiral-in/out trajectory, and acquiring a second set of spiral interleaf data for each of the one or more spiral-in/out interleaves by performing a second sampling of each of the one or more locations in the k-space along a second redundant spiral-in/out trajectory, wherein the second redundant spiral-in/out trajectory corresponds to a time-reversed trajectory of the first redundant spiral-in/out trajectory. The method may yet further include combining the first set of spiral interleaf data and the second set of spiral interleaf data with an averaging operation such as to reduce artifacts.Type: GrantFiled: March 23, 2016Date of Patent: May 16, 2017Assignee: University of Virginia Patent FoundationInventors: Samuel W. Fielden, Craig H. Meyer, Xue Feng
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Patent number: 9589345Abstract: Systems and methods for accelerated arterial spin labeling (ASL) using compressed sensing are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds to one or more physiological activities of the subject. The method also includes performing image reconstruction using temporally constrained compressed sensing reconstruction on at least a portion of the acquired magnetic resonance data, wherein acquiring the magnetic resonance data includes receiving data associated with ASL of the area of interest of the subject.Type: GrantFiled: September 30, 2015Date of Patent: March 7, 2017Assignee: University of Virginia Patent FoundationInventors: Li Zhao, Xiao Chen, Samuel W. Fielden, Frederick H. Epstein, John P. Mugler, III, Manal Nicolas-Jilwan, Max Wintermark, Craig H. Meyer
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Publication number: 20160202335Abstract: Systems, methods of reducing off-resonance blurring in acquired magnetic resonance imaging data. The method includes acquiring a first set of spiral interleaf data for each of one or more spiral-in/out interleaves by performing a first sampling each of one or more locations in k-space along a first redundant spiral-in/out trajectory, and acquiring a second set of spiral interleaf data for each of the one or more spiral-in/out interleaves by performing a second sampling of each of the one or more locations in the k-space along a second redundant spiral-in/out trajectory, wherein the second redundant spiral-in/out trajectory corresponds to a time-reversed trajectory of the first redundant spiral-in/out trajectory. The method may yet further include combining the first set of spiral interleaf data and the second set of spiral interleaf data with an averaging operation such as to reduce artifacts.Type: ApplicationFiled: March 23, 2016Publication date: July 14, 2016Inventors: Samuel W. Fielden, Craig H. Meyer, Xue Feng
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Patent number: 9322896Abstract: Systems, methods of reducing off-resonance blurring in acquired magnetic resonance imaging data. The method includes acquiring a first set of spiral interleaf data for each of one or more spiral-in/out interleaves by performing a first sampling each of one or more locations in k-space along a first redundant spiral-in/out trajectory, and acquiring a second set of spiral interleaf data for each of the one or more spiral-in/out interleaves by performing a second sampling of each of the one or more locations in the k-space along a second redundant spiral-in/out trajectory, wherein the second redundant spiral-in/out trajectory corresponds to a time-reversed trajectory of the first redundant spiral-in/out trajectory. The method may yet further include combining the first set of spiral interleaf data and the second set of spiral interleaf data with an averaging operation such as to reduce artifacts.Type: GrantFiled: April 22, 2013Date of Patent: April 26, 2016Assignee: University of Virginia Patent FoundationInventors: Samuel W. Fielden, Craig H. Meyer, Xue Feng
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Publication number: 20160098835Abstract: Systems and methods for accelerated arterial spin labeling (ASL) using compressed sensing are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds to one or more physiological activities of the subject. The method also includes performing image reconstruction using temporally constrained compressed sensing reconstruction on at least a portion of the acquired magnetic resonance data, wherein acquiring the magnetic resonance data includes receiving data associated with ASL of the area of interest of the subject.Type: ApplicationFiled: September 30, 2015Publication date: April 7, 2016Inventors: Li Zhao, Xiao Chen, Samuel W. Fielden, Frederick H. Epstein, John P. Mugler, III, Manal Nicolas-Jilwan, Max Wintermark, Craig H. Meyer
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Patent number: 9183626Abstract: Systems and methods for accelerated arterial spin labeling (ASL) using compressed sensing are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds to one or more physiological activities of the subject. The method also includes performing image reconstruction using temporally constrained compressed sensing reconstruction on at least a portion of the acquired magnetic resonance data, wherein acquiring the magnetic resonance data includes receiving data associated with ASL of the area of interest of the subject.Type: GrantFiled: April 22, 2013Date of Patent: November 10, 2015Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Li Zhao, Xiao Chen, Samuel W. Fielden, Frederick H. Epstein, John P. Mugler, III, Manal Nicolas-Jilwan, Max Wintermark, Craig H. Meyer
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Publication number: 20140152304Abstract: Systems, methods of reducing off-resonance blurring in acquired magnetic resonance imaging data. The method includes acquiring a first set of spiral interleaf data for each of one or more spiral-in/out interleaves by performing a first sampling each of one or more locations in k-space along a first redundant spiral-in/out trajectory, and acquiring a second set of spiral interleaf data for each of the one or more spiral-in/out interleaves by performing a second sampling of each of the one or more locations in the k-space along a second redundant spiral-in/out trajectory, wherein the second redundant spiral-in/out trajectory corresponds to a time-reversed trajectory of the first redundant spiral-in/out trajectory. The method may yet further include combining the first set of spiral interleaf data and the second set of spiral interleaf data with an averaging operation such as to reduce artifacts.Type: ApplicationFiled: April 22, 2013Publication date: June 5, 2014Applicant: UNIVERSITY OF VIRGINIA LICENSING & VENTURES GROUPInventors: Samuel W. Fielden, Craig H. Meyer, Xue Feng
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Publication number: 20130315461Abstract: Systems and methods for accelerated arterial spin labeling (ASL) using compressed sensing are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds to one or more physiological activities of the subject. The method also includes performing image reconstruction using temporally constrained compressed sensing reconstruction on at least a portion of the acquired magnetic resonance data, wherein acquiring the magnetic resonance data includes receiving data associated with ASL of the area of interest of the subject.Type: ApplicationFiled: April 22, 2013Publication date: November 28, 2013Applicant: UNIVERSITY OF VIRGINIA LICENSING & VENTURES GROUPInventors: Li Zhao, Xiao Chen, Samuel W. Fielden, Frederick H. Epstein, John P. Mugler, III, Manal Nicolas-Jilwan, Max Wintermark, Craig H. Meyer
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Publication number: 20130278261Abstract: Systems and methods for magnetic resonance imaging (MRI) using side information for improved reconstruction are disclosed. In one aspect, in accordance with one example embodiment, images obtained using heteronuclei, such as Fluorine-19 (19F), can be reconstructed using one or more methods to provide improved resolution and detail. The system can use anatomical proton MRI scans. The system can use multiple smoothing techniques to improve the signal-to-noise ratio (SNR). The system can also use weighted smoothing using information from anatomical proton MRI scans to improve resolution.Type: ApplicationFiled: April 22, 2013Publication date: October 24, 2013Applicant: UNIVERSITY OF VIRGINIA LICENSING & VENTURES GROUPInventors: Samuel W. Fielden, Craig H. Meyer