Abstract: The present invention provides a commode comprising: a frame, a seat-shell that rests on the frame, and a pan cover wherein in use a disposable pan rests on the seat shell. Commodes of the invention have one or more of the following features: they are portable, robust, easy and quick to clean, are simple and easy to manufacture and store. They have relatively few parts to assist in manufacture, repair, and cleaning. They are easy and comfortable to use and, as far as possible, preserve the users' dignity.

Abstract: Compounds of the general formula ##STR1## wherein Ph is a phenyl group which is optionally substituted by one or more substituents selected from halo (i.e. fluoro, chloro, bromo or iodo), C.sub.1-4 alkyl, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, nitro, sulphonyl, aminosulphonyl, trihalomethyl, carboxy, C.sub.1-4 alkoxycarbonyl, amido, C.sub.1-4 alkylamido, C.sub.1-4 alkoxy, C.sub.2-4 alkenyl, cyano, aminomethyl, or methylsulphonyl; Y is a group of formula ##STR2## where R.sup.1 is hydrogen or methyl; R.sup.2 is alkyl of 1 to 3 carbon atoms or is methylthiomethyl; and Z is --OR.sup.3 or --NR.sup.4 R.sup.5 where R.sup.3, R.sup.4 and R.sup.5 are each hydrogen or alkyl of 1 to 4 carbon atoms and R.sup.3 can further be phenylalkyl having 1 to 3 carbon atoms in the alkylene moiety thereof, or phenyl; and basic salts thereof. These compounds have an advantageous enkephalinase inhibitory activity which renders the compounds useful in medical therapy, e.g.

Abstract: Novel peptides of formula (I)X--Tyr--X.sup.2 --Gly--Phe(4NO.sub.2)--Pro--NH.sub.2 (I)and salts thereof, wherein X is hydrogen or an amidino group and X.sup.2 is a radical selected from D-S-methylmethionyl and D-arginyl, have a selectively peripheral analgesic effect when administered to mammals.The compounds also exhibit antidiarrhoeal and antitussive activity and may thus be used in human or veterinary medicine for the relief or prevention of pain, for the treatment of diarrhoea or dysentery and for the suppression of cough.

Abstract: Compounds of the general formula ##STR1## wherein Ph is a phenyl group which is optionally substituted by one or more substituents selected from halo (i.e. fluoro, chloro, bromo or iodo), C.sub.1-4 alkyl, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, nitro, sulphonyl, aminosulphonyl, trihalomethyl, carboxy, C.sub.1-4 alkoxycarbonyl, amido, C.sub.1-4 alkylamido C.sub.1-4 alkoxy, C.sub.2-4 alkenyl, cyano, aminomethyl or methylsulphonyl; R.sup.a and R.sup.b, which may be the same or different, each represents a hydrogen or alkali metal (e.g. sodium or lithium) atom or a C.sub.1-4 (e.g. ethyl) group; m is 0 or 1; Y is a group of formula:--NH--CH.sub.2 --CO--or a group of formula: ##STR2## where R.sup.1 is hydrogen or methyl;R.sup.2 is alkyl of 1 to 3 carbon atoms or is methylthiomethyl; andZ is --OR.sup.3 or --NR.sup.4 R.sup.5 where R.sup.3, R.sup.4 and R.sup.5 are each hydrogen or alkyl of 1 to 4 carbon atoms (i.e. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, or t-butyl) and R.sup.

Abstract: Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met.Gly.Phe (4NO.sub.2).ProNH.sub.2 and Tyr.D-Met(O). Gly. Phe(4NO.sub.2). ProNH.sub.2 as anti-diarrhoeals and anti-tussives.

Abstract: Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met. Gly.Phe(4NO.sub.2).ProNH.sub.2 and Tyr.D-Met(O).Gly.Phe(4NO.sub.2).ProNH.sub.2 as anti-diarrhoeals and anti-tussives.

Abstract: Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met.Gly.Phe(4NO.sub.2).ProNH.sub.2 and Tyr.D-Met(O).Gly.Phe(4NO.sub.2).ProNH.sub.2 as anti-diarrhoeals and anti-tussives.

Abstract: Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met. Gly.Phe (4NO.sub.2). ProNH.sub.2 and Tyr. D-Met(O). Gly. Phe(4NO.sub.2). ProNH.sub.2 as anti-diarrhoeals and anti-tussives.

Abstract: The present invention provides novel peptides of formula (I):R--(X.sup.1).sub.m --(X.sup.2).sub.n --X.sup.3 --X.sup.4 --X.sup.5 --X.sup.6 --X.sup.7 --(X.sup.8).sub.p --(X.sup.9).sub.q --R.sup.1 (I)together with their salts, esters, amides, N-alkylamides and N,N-dialkylamides and acid addition salts thereof.These compounds exhibit morphine agonist activity in both in vitro and in vivo tests and may be used in the treatment of mammals in the fields of both human and veterinary medicine in any condition where an agent with a morphine-like effect is indicated.

Abstract: A method for the induction and/or maintenance of anaesthesia or of neuroleptanalgesia in a mammal comprising the administration to the mammal of an anaesthetic-effective or of a neuroleptanalgesic-effective, non-toxic amount of a peptide of formulaH.Tyr.D-Ala.Gly.Phe.D-Leu.NHEtor a pharmacologically and pharmaceutically acceptable acid addition salt thereof.

Abstract: Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met.Gly.Phe(4NO.sub.2).ProNH.sub.2 and Tyr.D-Met(O).Gly.Phe(4NO.sub.2).ProNH.sub.2 as anti-diarrhoeals and anti-tussives.

Abstract: Reagent of value in the radioimmunoassay of digoxin. Also provided by the invention are a radioimmunoassay method utilizing such reagent and a test kit suitable for use in performing the assay.

Abstract: A method for the induction and/or maintenance of anaesthesia or of neuroleptanalgesia in a mammal comprising the administration to the mammal of an anaesthetic-effective or of a neuroleptanalgesic-effective, non-toxic amount of a peptide of formulaH.Tyr.D-Ala.Gly.Phe.D-Leu.NHEtor a pharmacologically and pharmaceutically acceptable acid addition salt thereof.

Abstract: Immunogenic conjugates of prostaglandins of the A, B, D and E series and their structural analogues of value in the proplylaxis or therapy in mammals of pathological conditions in which prostaglandins are involved. Also provided are pharmaceutical formulations comprising the conjugates together with a carrier therefor and methods for the treatment of mammals comprising the administration thereto of a conjugate or formulation thereof.

Abstract: Novel peptide compounds of the formulaGlu-His-X.sup.3 -X.sup.4 -X.sup.5 -X.sup.6 -X.sup.7 -X.sup.8 -Pro-Ware provided together with their acid addition salts and their complexes with pharmaceutically acceptable metals. The compounds are LH-RH analogues and together with their salts and complexes exhibit LH-RH agonist activity. In the formulaX.sup.3 and X.sup.5 are the same or different and each is phenylalanyl optionally substituted in the benzene ring;X.sup.4 and X.sup.6 are the same or different and each is selected from glycyl, alanyl (D- or L-) and asparaginyl;X.sup.7 is a radical of a neutral hydrophobic non-sulphur containing non-heterocyclic amino acid;X.sup.8 is a radical of a basic amino acid or is glycyl or phenylalanyl optionally substituted in the benzene ring; andW is selected from glycine amide and a group --NR.sup.1 R.sup.2.All references are to the L-amino acids and their radicals except in the case of glycine and unless otherwise stated.

Abstract: The present invention provides novel peptides of formula (I):R--(X.sup.1).sub.m --(X.sup.2).sub.n --X.sup.3 --X.sup.4 --X.sup.5 --X.sup.6 --X.sup.7 --(X.sup.8).sub.p --(X.sup.9).sub.q --R.sup.1 (I)together with their salts, esters, amides, N-alkylamides and N,N-dialkylamides and acid addition salts thereof.These compounds exhibit morphine agonist activity in both in vitro and in vivo tests and may be used in the treatment of mammals in the fields of both human and veterinary medicine in any condition where an agent with a morphine-like effect is indicated.