Abstract: There is disclosed a rivet die (13) for a rivet setting tool (2). The rivet die (13) comprises a main body (20) that defines an upper surface (39). The rivet die (13) further comprises a die cavity (21) that is formed in the upper surface (39). The die cavity (21) is defined at least in part by a base surface (42). The base surface (42) comprises a groove (50) that extends at least partly around a central axis C, a first portion (46) through which the central axis C extends, and a second portion (48). The groove (50) is disposed radially outwards of the first portion (46). The second portion (48) is disposed radially outwards of the groove (50). The groove (50) and the second portion 48 border one another at an interface (56). The first portion (46) defines a first portion depth d1 in a direction along the central axis C. The interface (56) defines an interface depth d5 in a direction along the central axis C. The first portion depth dl is less than the interface depth d5.

Abstract: A roll transfer assembly for a web processing system includes a support beam configured to be mounted to a frame. The assembly includes a segmented roll assembly mounted to the support beam and includes a first and second end segments and a central segment positioned between the first and second end segments. The assembly includes a first transfer roll positioned between the first end segment and the central segment and a second transfer roll positioned between the second segment and the central segment. The assembly includes an actuation assembly that includes a first drive system configured to translationally move the first transfer roll and the second transfer roll. A second drive system is configured to move the roll transfer assembly relative to the frame.

Abstract: A propulsion system is provided. The propulsion system includes a housing and a rotatable vector-flow nozzle that extends from the housing and is configured to eject a fluid in a plurality of directions. The propulsion system also has a propeller disposed within the housing and in fluid communication with the rotatable vector-flow nozzle. The propeller includes a blade that pitches in a first direction. A fluid intake is located at an end of the propulsion system housing and opposite the rotatable vector-flow nozzle. The propulsion system also has an intake grate at the fluid intake where the intake grate defines a hub and a rim spaced apart and about the hub. The intake grate includes a plurality of intake grate blades that pitch in a second direction opposite the first direction.

Abstract: An electric direct-drive motor for an underwater vehicle comprises a fully-encapsulated stator and a rotor. The fully-encapsulated stator may comprise a stator encapsulated in a thermally-conductive and electrically-isolative encapsulant. The encapsulant may be configured to align the rotor within the fully-encapsulated stator. The fully-encapsulated stator may have an internal surface to operate as a bearing surface for the rotor. A radial gap between the rotor and the internal surface may provide a fluid bearing between the rotor and stator. The internal surface of the fully-encapsulated stator operates as a bearing surface for the rotor and the radial gap provides a fluid bearing when operating in a flooded assembly. This allows the electric direct-drive motor to be directly exposed to seawater and the high external water pressure eliminating any need for a pressure compensated housing and dynamic seals and bearings.

Abstract: Provided herein are recombinant nucleic acids that reduce expression of CD5, CBLB, CISH, DGKA, DGKZ, DNMT3A, MAP4K1, NR4A1, PTPN2, TET2, or ZC3H12A and cells comprising such recombinant nucleic acids. Also provided are methods of making and using such cells.

Abstract: A rivet die for a rivet setting tool configured to set a fully tubular or semi tubular self-piercing rivet into a workpiece, said rivet having an outer shank diameter D. The rivet die comprises a main body and a mounting stem depending from the main body. The main body is generally cylindrical about a central axis. The main body has an upper surface. A die cavity is formed in the upper surface. The die cavity includes a central bore which extends along the central axis all the way through the mounting stem. The diameter of the central bore at the upper surface is less than the outer shank diameter.

Abstract: Provided herein are chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.

Abstract: A self-piercing rivet (10) for joining high strength aluminium, the rivet comprising a head (12) and a shank (14) which is provided with a bore (16), wherein the shank has a diameter D1 of between 3.6 mm and 4.4 mm, and wherein a tip (28) of the shank is separated by a radial distance Tx of least 0.2 mm from an outer diameter of the shank.

Abstract: A method for joining two workpieces, which each have a joining surface for joining the workpieces, applies a viscous adhesive to a first joining surface in the form of a continuous material strand along an application path extending in an application direction. The joining surfaces are arranged facing each other in order to delimit an intermediate gap, in which the material strand is arranged. The workpieces are joined to each other in the region of the material strand by at least one further joining device. The first joining surface includes an alternately arranged hybrid adhering regions and adhering regions. A further joining device is arranged in each hybrid adhering region. The adhesive amount applied in each length unit measured in the application direction in the hybrid adhering regions is less than the adhesive amount applied in each length unit measured in the application direction in the adhering regions.

Abstract: According to a first aspect of the invention there as provided a method of forming a riveted joint comprising a UHSS layer and a non-UHSS layer using a self-piercing rivet comprising a head and a shank, an outer diameter of a top of the shank being greater than an outer diameter of a bottom of the shank before insertion of the rivet, the method comprising pushing the self-piercing rivet into the UHSS layer such that the lower portion of the shank flares outwards and cuts a slug from the UHSS, and pushing the flared shank of the self-piercing rivet and the slug into the non-UHSS layer such that the non-UHSS layer deforms into a die recess and flows around an outer surface of the flared shank.

Abstract: According to a first aspect of the application, there as provided a method of forming a riveted joint comprising a UHSS layer and a non-UHSS layer using a self-piercing rivet comprising a head and a shank, an outer diameter of a top of the shank being greater than an outer diameter of a bottom of the shank before insertion of the rivet, the method comprising pushing the self-piercing rivet into the UHSS layer such that the lower portion of the shank flares outwards and cuts a slug from the UHSS, and pushing the flared shank of the self-piercing rivet and the slug into the non-UHSS layer such that the non-UHSS layer deforms into a die recess and flows around an outer surface of the flared shank.

Abstract: The disclosure described herein can be used for very rapid real-time acquisition of short DNA reads that can be used for time-sensitive aneuploidy detection in prenatal and IVF care as well as sequencing of small DNA fragments and amplicons in the field or clinic. This ability can expand the utility of nanopore-based sequencing methods for clinical and research applications.

Abstract: Disclosed herein are methods to determine the abundance of nucleotide sequences relative to other nucleotide sequences in a complex genome.

Abstract: A system for controlling parameters of polymeric film includes an extruder and a die which has a gap. A plurality of regulators are positioned along the die for regulating the gap. A cooling cylinder is located downstream of the die and a polymeric melt extends from the die to the cooling cylinder. An applicator device for creating a tracking lane in the polymeric melt is located proximate the gap. A sensor system is located downstream from the gap in a measuring location. The sensor system locates a transverse point for the respective tracking lane in the polymeric film at the measuring location. The sensor system is in communication with the regulators to adjust the gap based on a correlation of tracking lane position at origin point and transverse point at the measuring location.

Abstract: According to a first aspect of the invention there as provided a method of forming a riveted joint comprising a UHSS layer and a non-UHSS layer using a self-piercing rivet comprising a head and a shank, an outer diameter of a top of the shank being greater than an outer diameter of a bottom of the shank before insertion of the rivet, the method comprising pushing the self-piercing rivet into the UHSS layer such that the lower portion of the shank flares outwards and cuts a slug from the UHSS, and pushing the flared shank of the self-piercing rivet and the slug into the non-UHSS layer such that the non-UHSS layer deforms into a die recess and flows around an outer surface of the flared shank.

Abstract: A method for joining two workpieces, which each have a joining surface for joining the workpieces, applies a viscous adhesive to a first joining surface in the form of a continuous material strand along an application path extending in an application direction. The joining surfaces are arranged facing each other in order to delimit an intermediate gap, in which the material strand is arranged. The workpieces are joined to each other in the region of the material strand by at least one further joining device. The first joining surface includes an alternately arranged hybrid adhering regions and adhering regions. A further joining device is arranged in each hybrid adhering region. The adhesive amount applied in each length unit measured in the application direction in the hybrid adhering regions is less than the adhesive amount applied in each length unit measured in the application direction in the adhering regions.

Abstract: The disclosure described herein can be used for very rapid real-time acquisition of short DNA reads that can be used for time-sensitive aneuploidy detection in prenatal and WF care as well as sequencing of small DNA fragments and amplicons in the field or clinic. This ability can expand the utility of nanopore-based sequencing methods for clinical and research applications.

Abstract: Provided are novel anti-MFI2 antibodies and antibody drug conjugates, and methods of using such anti-MFI2 antibodies and antibody drug conjugates to treat cancer.

Abstract: Anti-DLL3 antibodies and antibody drug conjugates for use in the diagnosis and treatment of melanoma.

Abstract: A multi-core computer processor including a plurality of processor cores interconnected in a Network-on-Chip (NoC) architecture, a plurality of caches, each of the plurality of caches being associated with one and only one of the plurality of processor cores, and a plurality of memories, each of the plurality of memories being associated with a different set of at least one of the plurality of processor cores and each of the plurality of memories being configured to be visible in a global memory address space such that the plurality of memories are visible to two or more of the plurality of processor cores, wherein at least one of a number of the processor cores, a size of each of the plurality of caches, or a size of each of the plurality of memories is configured for performing a reverse-time-migration (RTM) computation.