Patents by Inventor Samuele Frigoli

Samuele Frigoli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of enzalutamide
    Patent number: 10035776
    Abstract: Disclosed is a process for the preparation of Enzalutamide comprising the reaction (Scheme 2), wherein R can be alkyl, aryl, aryl-alkyl or heterocyclyl.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: July 31, 2018
    Assignee: Olon S.P.A.
    Inventors: Samuele Frigoli, Davide Longoni, Marco Alpegiani, Claudio Fuganti, Stefano Serra
  • INDUSTRIAL PROCESS FOR THE PREPARATION OF ENZALUTAMIDE
    Publication number: 20180148416
    Abstract: Disclosed is an efficient method of synthesising Enzalutamide, which comprises the cyclisation reaction of isothiocyanate 1 with acid 3 pre-treated with a silylating agent, or reacting 1 and 3 in the presence of a silylating agent.
    Type: Application
    Filed: May 24, 2016
    Publication date: May 31, 2018
    Applicant: Olon S.P.A.
    Inventors: Samuele Frigoli, Davide Longoni, Marco Alpegiani
  • PROCESS FOR THE PREPARATION OF ENZALUTAMIDE
    Publication number: 20180141914
    Abstract: Disclosed is a process for the preparation of Enzalutamide comprising the reaction (Scheme 2), wherein R can be alkyl, aryl, aryl-alkyl or heterocyclyl.
    Type: Application
    Filed: May 24, 2016
    Publication date: May 24, 2018
    Applicant: Olon S.P.A.
    Inventors: Samuele Frigoli, Davide Longoni, Marco Alpegiani, Claudio Fuganti, Stefano Serra
  • Crystalline salts of asenapine
    Patent number: 9447109
    Abstract: Disclosed is asenapine phosphate of formula (I) and its enantiomer (I) which can be used to prepare asenapine maleate. Further disclosed is a monoclinic crystalline form of asenapine maleate.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: September 20, 2016
    Assignee: OLON S.P.A.
    Inventors: Samuele Frigoli, Davide Longoni, Tamara Danelli, Marco Alpegiani
  • CRYSTALLINE SALTS OF ASENAPINE
    Publication number: 20140051741
    Abstract: Disclosed is asenapine phosphate of formula (I) and its enantiomer (I) which can be used to prepare asenapine maleate. Further disclosed is a monoclinic crystalline form of asenapine maleate.
    Type: Application
    Filed: April 30, 2012
    Publication date: February 20, 2014
    Applicant: OLON SPA
    Inventors: Samuele Frigoli, Davide Longoni, Tamara Danelli, Marco Alpegiani
  • Process for the preparation of 1-naphthol mixed ethers and intermediates of crystalline forms of (+) and (?)-duloxetine
    Patent number: 7553978
    Abstract: The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-1-(2-thienyl)-propan-1-ol in the presence of 1,3-dimethyl-2-oxo-hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: June 30, 2009
    Assignee: Solmag S.p.A.
    Inventors: Samuele Frigoli, Claudio Fuganti, Roberta Pizzocaro
  • Process for the Preparation of 1-Naphthol Mixed Ethers and Intermediates of Crystalline Forms of (+) and (-)-Duloxetine
    Publication number: 20080287693
    Abstract: The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-1-(2-thienyl)-propan-1-ol in the presence of 1,3-dimethyl-2-oxo-hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed.
    Type: Application
    Filed: October 13, 2006
    Publication date: November 20, 2008
    Inventors: Samuele Frigoli, Claudio Fuganti, Roberta Pizzocaro
  • Process for the preparation of Tazarotene
    Patent number: 7273937
    Abstract: Tazarotene is prepared by deoxygenation of the corresponding S-oxide, in turn obtained according to two alternative synthetic pathways.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: September 25, 2007
    Assignee: Solmag S.p.A.
    Inventors: Samuele Frigoli, Claudio Fuganti, Stefano Serra, Francesco Pizzocaro, Angelo Bedeschi, Paolo Tubertini
  • Process for the preparation of Tazarotene
    Publication number: 20060205950
    Abstract: Tazarotene is prepared by deoxygenation of the corresponding S-oxide, in turn obtained according to two alternative synthetic pathways.
    Type: Application
    Filed: March 7, 2006
    Publication date: September 14, 2006
    Applicant: Solmag S.p.A.
    Inventors: Samuele Frigoli, Claudio Fuganti, Stefano Serra, Francesco Pizzocaro, Angelo Bedeschi, Paolo Tubertini