Patents by Inventor Sandeep Mekde

Sandeep Mekde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pure intermediate
    Patent number: 9150524
    Abstract: The present invention relates to an improved process for the preparation of Letrozole (I) and its synthetic intermediate 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III). In particular, it relates to a process to prepare Letrozole and its intermediate (III) substantially free from regioisomeric impurities. The present invention further relates to acid addition salts of 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III) such as the oxalate salt, and also to Letrozole (I), the intermediate (III) and salts thereof preparable by the processes of the present invention.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: October 6, 2015
    Assignee: Generics [UK] Limited
    Inventors: Vinayak Govind Gore, Vinay Kumar Shukla, Sandeep Mekde, Suresh Hasbe, Shreyas Bhandari, Dhananjay Shinde, Madhukar Shaligram Patil
  • CRYSTALLINE FORMS OF THALIDOMIDE AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20150218126
    Abstract: The present invention related to crystalline forms of thalidomide having a high polymorphic purity and to processes for their preparation. The present invention also relates to pharmaceutical preparations comprising the crystalline forms for the treatment of patients suffering from autoimmune, inflammatory or angiogenic disorders.
    Type: Application
    Filed: February 12, 2015
    Publication date: August 6, 2015
    Applicant: GENERICS [UK] LIMITED
    Inventors: Vinayak Govind Gore, Vinay Kumar Shukla, Madhukar Patil, Sandeep Mekde
  • Process for preparing bosentan
    Patent number: 8785461
    Abstract: The present invention relates to a novel intermediate useful in the preparation of bosentan and to processes for the preparation of said intermediate and bosentan. The invention further relates to compositions comprising bosentan prepared according to the processes of the invention and their use in the treatment of endothelin-receptor mediated disorders.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: July 22, 2014
    Assignee: Generics [UK] Limited
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Vikas Padalkar, Hemant Mande
  • Process for the introduction of hydroxyethoxy side chain in bosentan
    Patent number: 8664390
    Abstract: The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: March 4, 2014
    Assignee: Generics (UK) Limited
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Sonawane, Dattatrey Kokane, Sandeep Mekde, Dattatraya Shinde, Prakash Bansode
  • Crystalline forms of bosentan
    Patent number: 8530488
    Abstract: The present invention relates to novel crystalline forms of bosentan and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said crystalline forms and use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: September 10, 2013
    Assignee: Generics [UK] Limited
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Prakash Bansode, Dattatraya Shinde, Sunanda Phadtare
  • Pure Intermediate
    Publication number: 20130203826
    Abstract: The present invention relates to an improved process for the preparation of Letrozole (I) and its synthetic intermediate 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III). In particular, it relates to a process to prepare Letrozole and its intermediate (III) substantially free from regioisomeric impurities. The present invention further relates to acid addition salts of 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III) such as the oxalate salt, and also to Letrozole (I), the intermediate (III) and salts thereof preparable by the processes of the present invention.
    Type: Application
    Filed: August 26, 2011
    Publication date: August 8, 2013
    Applicant: Generics [UK] Limited
    Inventors: Vinayak Govind Gore, Vinay Kumar Shukla, Sandeep Mekde, Suresh Hasbe, Shreyas Bhandari, Dhananjay Shinde, Madhukar Shaligram Patil
  • CRYSTALLINE FORMS OF THALIDOMIDE AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20130143923
    Abstract: The present invention related to crystalline forms of thalidomide having a high polymorphic purity and to processes for their preparation. The present invention also relates to pharmaceutical preparations comprising the crystalline forms for the treatment of patients suffering from autoimmune, inflammatory or angiogenic disorders.
    Type: Application
    Filed: June 9, 2011
    Publication date: June 6, 2013
    Inventors: Vinayak Govind Gore, Vinay Kumar Shukla, Madhukar Patil, Sandeep Mekde
  • Polymorphic forms
    Patent number: 8288401
    Abstract: Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: October 16, 2012
    Assignee: Generics [UK] Limited
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Dattaatraya Shinde, Prakash Bansode
  • PROCESS FOR PREPARING BOSENTAN
    Publication number: 20110039871
    Abstract: The present invention relates to a novel intermediate useful in the preparation of bosentan and to processes for the preparation of said intermediate and bosentan. The invention further relates to compositions comprising bosentan prepared according to the processes of the invention and their use in the treatment of endothelin-receptor mediated disorders.
    Type: Application
    Filed: February 6, 2009
    Publication date: February 17, 2011
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Vikas Padalkar, Hemant Mande
  • NOVEL POLYMORPHIC FORMS
    Publication number: 20100261742
    Abstract: Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.
    Type: Application
    Filed: May 8, 2008
    Publication date: October 14, 2010
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Dattatraya Shinde, Prakash Bansode
  • PROCESS FOR THE INTRODUCTION OF HYDROXYETHOXY SIDE CHAIN IN BOSENTAN
    Publication number: 20100249162
    Abstract: The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.
    Type: Application
    Filed: June 27, 2008
    Publication date: September 30, 2010
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Sonawane, Dattatrey Kokane, Sandeep Mekde, Dattatraya Shinde, Prakash Bansode
  • NOVEL PROCESS
    Publication number: 20100234468
    Abstract: The present invention relates to a process for the preparation of polymorphic forms of the R- and S-enantiomers of modafinil, R-(?)-2-benzhydrylsulfinylacetamide and S-(+)-2-benzhydrylsulfinylacetamide respectively.
    Type: Application
    Filed: May 30, 2008
    Publication date: September 16, 2010
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Dattatrey Kokane