Abstract: Disclosed herein include methods, compositions, and kits suitable for use in producing insulin in a mammalian subject. In some embodiments, the method comprises implanting a perforated cell delivery device comprising a genetically modified cell or population thereof into the subject. Also provided are combination products comprising the perforated cell delivery device comprising a genetically modified cell or population thereof.

Abstract: The present disclosure relates to methods, compositions and kits for treating conditions that are related with angiopoietin-like 3 (ANGPTL3) by gene editing.

Abstract: The present disclosure relates to methods, compositions and kits for treating conditions that are related with angiopoietin-like 3 (ANGPTL3) by gene editing.

Abstract: The present disclosure relates to methods, compositions and kits for treating conditions that are related with angiopoietin-like 3 (ANGPTL3) by gene editing.

Abstract: The present disclosure relates to methods, compositions and kits for treating conditions that are related with angiopoietin-like 3 (ANGPTL3) by gene editing.

Abstract: The technologies described herein serve contextually relevant advertisements under a guaranteed advertisement campaign. A publisher retrieves a guaranteed advertisement campaign related to a webpage available for serving an advertisement, and identifies a set of advertisements relating to the guaranteed advertisement campaign. Advertisement selecting circuitry of the publisher determines whether an advertisement that is contextually relevant to content published at the webpage is present in the set of advertisements. If there is no contextually relevant advertisement in the set of advertisements, the advertisement selecting circuitry selects an alternative advertisement from the set of advertisements that minimizes an under-delivery risk related to the guaranteed advertisement campaign. If there is a contextually relevant advertisement in the set of advertisements, the advertisement selecting circuitry selects the contextually relevant advertisement.

Abstract: A request to establish a communication session is received. A clone of a communication system object with configuration information is produced and associated with a session identifier for the communication session. The session identifier for the communication session is sent to a client. When an administrator wants to make updates to re-bootable parameter(s) in the configuration information, the re-bootable parameter(s) are updated in the clone of the communication system object based on the session identifier. A message to save the session information with the session identifier is received. In response to receiving the save session information message, the clone with the updates to the re-bootable parameter(s) is sent to the communication system. This results in the communication system rebooting. By updating multiple re-bootable parameters in the clone of the communication system, a single reboot will occur. This reduces the total number of reboots that would have occurred previously.

Abstract: The technologies described herein serve contextually relevant advertisements under a guaranteed advertisement campaign. A publisher retrieves a guaranteed advertisement campaign related to a webpage available for serving an advertisement, and identifies a set of advertisements relating to the guaranteed advertisement campaign. Advertisement selecting circuitry of the publisher determines whether an advertisement that is contextually relevant to content published at the webpage is present in the set of advertisements. If there is no contextually relevant advertisement in the set of advertisements, the advertisement selecting circuitry selects an alternative advertisement from the set of advertisements that minimizes an under-delivery risk related to the guaranteed advertisement campaign. If there is a contextually relevant advertisement in the set of advertisements, the advertisement selecting circuitry selects the contextually relevant advertisement.

Abstract: A request to establish a communication session is received. A clone of a communication system object with configuration information is produced and associated with a session identifier for the communication session. The session identifier for the communication session is sent to a client. When an administrator wants to make updates to re-bootable parameter(s) in the configuration information, the re-bootable parameter(s) are updated in the clone of the communication system object based on the session identifier. A message to save the session information with the session identifier is received. In response to receiving the save session information message, the clone with the updates to the re-bootable parameter(s) is sent to the communication system. This results in the communication system rebooting. By updating multiple re-bootable parameters in the clone of the communication system, a single reboot will occur. This reduces the total number of reboots that would have occurred previously.

Abstract: A new approach towards transmitting media across a network is disclosed. In an embodiment, the sender prioritizes the data to be sent from a pool of candidate data, and sends it under some bandwidth constraint. The pool of candidate data reflects the present state of the media, and certain data may be discarded without being sent if it becomes irrelevant to the present state of the media. The receiver sends feedback regarding what data is received by it, which may be used for choosing candidate data, or for prioritizing it.