Abstract: A method and system for patient-specific predicting of cyclic loading failure of a cardiac implant. The method includes providing an implant model representing a three dimensional mesh based representation of a cardiac implant, and providing a four-dimensional, 4D, patient-specific anatomical model representing a mesh based representation of a patient-specific cardiac region including a deployment site for the cardiac implant in a plurality of states corresponding to a plurality of moments in the cardiac cycle. A computer calculates deformation of the implant model deployed at the deployment site when, or before, the 4D patient-specific anatomical model transforms consecutively through the plurality of states, and the computer determines a risk of cyclic loading failure of the cardiac implant on the basis of the calculated implant deformation.