Patents by Inventor Sandhya Kortagere

Sandhya Kortagere has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING OR PREVENTING AN ATTENTION DISORDER, COGNITIVE DISORDER, AND/OR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER
    Publication number: 20240074993
    Abstract: The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention. The present invention further provides a method of treating or preventing dementia associated with a neurodegenerative disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention.
    Type: Application
    Filed: September 5, 2023
    Publication date: March 7, 2024
    Inventor: Sandhya Kortagere
  • Methods of treating or preventing an attention disorder, cognitive disorder, and/or dementia associated with a neurodegenerative disorder
    Patent number: 11744810
    Abstract: The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention. The present invention further provides a method of treating or preventing dementia associated with a neurodegenerative disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: September 5, 2023
    Assignee: Drexel University
    Inventor: Sandhya Kortagere
  • PXR agonists and uses thereof for gut barrier dysfunction treatment and prevention
    Patent number: 11724998
    Abstract: Small molecule agonists of the pregnane X receptor (PXR), compositions and methods are disclosed for treating or preventing gut barrier dysfunction, an illness associated with gut barrier dysfunction, toxic or inflammatory injury to intestines, or leaky intestinal (gut) syndrome in a subject.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: August 15, 2023
    Assignees: Albert Einstein College of Medicine, Drexel University, Palacky University Olomouc
    Inventors: Sridhar Mani, Felix Kopp, Zdenek Dvorak, Sandhya Kortagere, Chamini Karunaratne
  • GLUTAMATE TRANSPORTER ACTIVATORS AND METHODS USING SAME
    Publication number: 20220402938
    Abstract: The present invention provides compounds useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compound stimulates a glutamate transporter.
    Type: Application
    Filed: June 23, 2022
    Publication date: December 22, 2022
    Inventors: Sandhya Kortagere, Andreia C. K. Mortensen, Ole V. Mortensen, Joseph M. Salvino
  • NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE
    Publication number: 20220233475
    Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
    Type: Application
    Filed: February 8, 2022
    Publication date: July 28, 2022
    Inventors: Sandhya Kortagere, Eldo V. Kuzhikandahil
  • Glutamate transporter activators and methods using same
    Patent number: 11377452
    Abstract: The present invention provides compounds useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compound stimulates a glutamate transporter.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: July 5, 2022
    Assignee: Drexel University
    Inventors: Sandhya Kortagere, Andreia C. K. Mortensen, Ole V. Mortensen, Joseph M. Salvino
  • Compounds and methods of treating or ameliorating an IL-1R-mediated disease or disorder using same
    Patent number: 11345696
    Abstract: The present invention provides compounds useful for treating or preventing an IL-1R-mediated disease or disorder. In certain embodiments, the disease or disorder comprises scleroderma.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: May 31, 2022
    Assignee: Drexel University
    Inventors: Sandhya Kortagere, Carol M. Artlett
  • D3 dopamine receptor agonists to treat dyskinesia in Parkinson's disease
    Patent number: 11266612
    Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: March 8, 2022
    Assignees: Drexel University, Rutgers, The State University of New Jersey
    Inventors: Sandhya Kortagere, Eldo V. Kuzhikandahil
  • METHOD FOR SYNTHESIZING D3 DOPAMINE RECEPTOR AGONISTS
    Publication number: 20220009876
    Abstract: An improved method for synthesizing a compound according to formula (I) by reaction of a compound of formula (II) with a sulfinamide according to formula (III). The resultant compound is then reduced and hydrolyzed, and optionally alkylated or arylated to arrive at the compound according to formula (I).
    Type: Application
    Filed: October 31, 2019
    Publication date: January 13, 2022
    Inventors: Thais Motria SIELECKI-DZURDZ, Baoyu Ml, Huiping ZHAO, Sandhya KORTAGERE
  • Methods of Treating or Preventing an Attention Disorder, Cognitive Disorder, and/or Dementia Associated with a Neurodegenerative Disorder
    Publication number: 20200397721
    Abstract: The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention. The present invention further provides a method of treating or preventing dementia associated with a neurodegenerative disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention.
    Type: Application
    Filed: June 4, 2020
    Publication date: December 24, 2020
    Inventor: Sandhya KORTAGERE
  • NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE
    Publication number: 20200390728
    Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
    Type: Application
    Filed: January 24, 2020
    Publication date: December 17, 2020
    Inventors: Sandhya KORTAGERE, Eldo V. KUZHIKANDAHIL
  • Glutamate Transporter Activators and Methods Using Same
    Publication number: 20200255445
    Abstract: The present invention provides compounds useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compound stimulates a glutamate transporter.
    Type: Application
    Filed: January 16, 2018
    Publication date: August 13, 2020
    Inventors: Sandhya Kortagere, Andreia C.K. Mortensen, Ole V. Mortensen, Joseph M. Salvino
  • Treatments for attention and cognitive disorders, and for dementia associated with a neurodegenerative disorder
    Patent number: 10695302
    Abstract: The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention. The present invention further provides a method of treating or preventing dementia associated with a neurodegenerative disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: June 30, 2020
    Assignee: Drexel University
    Inventor: Sandhya Kortagere
  • Ddopamine receptor agonists to treat dyskinesia in Parkinson's disease
    Patent number: 10543180
    Abstract: The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: January 28, 2020
    Assignees: Drexel University, Rutgers, The State University of New Jersey
    Inventors: Sandhya Kortagere, Eldo V. Kuzhikandahil
  • PXR AGONISTS AND USES THEREOF FOR GUT BARRIER DYSFUNCTION TREATMENT AND PREVENTION
    Publication number: 20190367475
    Abstract: Small molecule agonists of the pregnane X receptor (PXR), compositions and methods are disclosed for treating or preventing gut barrier dysfunction, an illness associated with gut barrier dysfunction, toxic or inflammatory injury to intestines, or leaky intestinal (gut) syndrome in a subject.
    Type: Application
    Filed: January 18, 2018
    Publication date: December 5, 2019
    Inventors: Sridhar Mani, Felix Kopp, Zdenek Dvorak, Sandhya Kortagere, Chamini Karunaratne
  • COMPOUNDS AND METHODS OF TREATING OR AMELIORATING AN IL-1R-MEDIATED DISEASE OR DISORDER USING SAME
    Publication number: 20190367503
    Abstract: The present invention provides compounds useful for treating or preventing an IL-1R-mediated disease or disorder. In certain embodiments, the disease or disorder comprises scleroderma.
    Type: Application
    Filed: August 12, 2019
    Publication date: December 5, 2019
    Inventors: Sandhya KORTAGERE, Carol M. ARTLETT
  • Compounds and methods of treating or ameliorating an IL-1R-mediated disease or disorder using same
    Patent number: 10428059
    Abstract: The present invention provides compounds useful for treating or preventing an IL-1R-mediated disease or disorder. In certain embodiments, the disease or disorder comprises scleroderma.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: October 1, 2019
    Assignee: Drexel University
    Inventors: Sandhya Kortagere, Carol M. Artlett
  • NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME
    Publication number: 20190241578
    Abstract: The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.
    Type: Application
    Filed: April 19, 2019
    Publication date: August 8, 2019
    Inventors: Sandhya KORTAGERE, Ole MORTENSEN, Andreia C. K. MORTENSEN, Joseph M. SALVINO
  • Compositions useful in treating brain-related diseases or disorders and methods using same
    Patent number: 10287290
    Abstract: The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: May 14, 2019
    Assignee: Drexel University
    Inventors: Sandhya Kortagere, Ole Mortensen, Andreia C. K. Mortensen, Joseph M. Salvino
  • NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER
    Publication number: 20180092865
    Abstract: The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention. The present invention further provides a method of treating or preventing dementia associated with a neurodegenerative disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention.
    Type: Application
    Filed: November 22, 2017
    Publication date: April 5, 2018
    Applicant: Drexel University
    Inventor: Sandhya KORTAGERE