Patents by Inventor Sandhya PANDE

Sandhya PANDE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Auxotrophic Cells for Virus Production and Compositions and Methods of Making
    Publication number: 20240124850
    Abstract: Disclosed herein are cells and cell lines that are selected for retention of at least two exogenous nucleic acid constructs using a single selective pressure. Also disclosed herein are compositions and methods for generating recombinant cells and cell lines using a single selective pressure.
    Type: Application
    Filed: March 3, 2022
    Publication date: April 18, 2024
    Inventors: Kenneth Prentice, Lindsey Nicole Deis Huffman, Sandhya Pande
  • STABLE CELL LINES FOR INDUCIBLE PRODUCTION OF rAAV VIRIONS
    Publication number: 20220145328
    Abstract: Described herein are polynucleotide constructs and stable cell lines for inducible production of rAAV virions within which are packaged a payload polynucleotide.
    Type: Application
    Filed: July 30, 2021
    Publication date: May 12, 2022
    Inventors: Kenneth Prentice, Sandhya Pande
  • Use of monensin to regulate glycosylation of recombinant proteins
    Patent number: 11299760
    Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell-cycle inhibitors to growing cell cultures.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: April 12, 2022
    Assignee: Amgen Inc.
    Inventors: Sandhya Pande, Mirna Mujacic
  • USE OF MONENSIN TO REGULATE GLYCOSYLATION OF RECOMBINANT PROTEINS
    Publication number: 20210395793
    Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell-cycle inhibitors to growing cell cultures.
    Type: Application
    Filed: September 1, 2021
    Publication date: December 23, 2021
    Applicant: Amgen Inc.
    Inventors: Sandhya PANDE, Mirna MUJACIC
  • Use of monensin to regulate glycosylation of recombinant proteins
    Patent number: 11130980
    Abstract: Methods of modulating high mannose glycoform content of a protein in a cell culture by contacting the cells expressing the protein of interest with monesin are provided.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: September 28, 2021
    Assignee: Amgen Inc.
    Inventors: Sandhya Pande, Mirna Mujacic
  • BIDIRECTIONAL CHEF1 VECTORS
    Publication number: 20210062217
    Abstract: The invention provides bidirectional expression vectors comprising Chinese hamster ovary elongation factor 1-a (CHEF1) transcriptional regulatory DNA elements, a gene of interest (GO I), a minimal cytomegalovirus (minCMV) and a selectable marker (SM) and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention also provides method for increasing heterologous protein expression in a host cell comprising culturing the host cell the bidirectional expression vector(s).
    Type: Application
    Filed: January 9, 2019
    Publication date: March 4, 2021
    Inventor: Sandhya Pande
  • USE OF MONENSIN TO REGULATE GLYCOSYLATION OF RECOMBINANT PROTEINS
    Publication number: 20160281124
    Abstract: Methods of modulating high mannose glycoform content of a protein in a cell culture by contacting the cells expressing the protein of interest with monesin are provided.
    Type: Application
    Filed: October 30, 2014
    Publication date: September 29, 2016
    Applicant: AMGEN INC.
    Inventors: Sandhya PANDE, Mirna MUJACIC