Patents by Inventor Sandhya Rani

Sandhya Rani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Beta R-1 chemokine
    Patent number: 6414118
    Abstract: The present invention provides an isolated polypeptide, designated Beta R1, whose production is selectively induced by IFN-&bgr; as compared to IFN-&agr;. The Beta R1 polypeptide is a chemokine whose expression is stimulated in T cells, astrocytes, and fibroblasts that have been—exposed to IFN-&bgr;. The present invention also provides an isolated polynucleotide that encodes the Beta R1 polypeptide and an isolated polynucleotide that encodes the Beta R1 promoter. The present invention also provides a method of identifying putative IFN-&bgr; mimics. In one embodiment, the method comprises the steps of providing cultured cells transfected with a polynucleotide construct that comprises a DNA sequence that encodes the Beta R1 promoter operatively linked to a reporter gene that encodes an assayable product; treating the transfected cells with the putative IFN-&bgr; mimic; and detecting the assayable product produced by the treated cells.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: July 2, 2002
    Assignee: The Cleveland Clinic Foundation
    Inventors: Richard Ransohoff, Sandhya Rani
  • DNA encoding a chemokine, Beta R1, comprising the Beta R1 promoter
    Patent number: 5977334
    Abstract: The invention provides a chemokine designated Beta R1, whose production in T cells, astrocytes, a fibroblasts is preferentially induced by IFN-.beta. as compared to IFN-.alpha.. A cDNA encoding the Beta R1 polypeptide and comprising the endogenous Beta R1 promoter is described. When coupled to a reporter gene, the promoter sequence may be used to screen for mimics of IFN-.beta. activity.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: November 2, 1999
    Assignee: The Cleveland Clinic Foundation
    Inventors: Richard Ransohoff, Sandhya Rani