Abstract: Saxitoxin analogue compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogues, methods of imaging, methods of treatment, including methods of treating pain, are provided. Saxitoxin (STX), gonyautoxin (GTX), and zetekitoxin, and variant STX compounds bind to sodium channels and are effective to reduce or block flow of sodium ions through such channels. Such channel block affects nerve and muscle action, and may be effective to reduce or block pain sensations, relax muscles, reduce muscle spasm, and reduce wrinkles. STX analogue binding to sodium channels may also be useful to locate, image, or mark sodium channels, and so be useful in studying sodium channels and sodium channel disorders, and in the diagnosis and treatment of patients suffering from sodium channel disorders. In embodiments, the variant STX compounds include conjugates having increased serum half-life as compared to STX when administered to a subject.

Abstract: A method for localizing and quantifying S1R role in nociceptive processing; for providing a guide to providing an analgesic therapy; of using an S1R selective ligand as a biomarker for pathphysiological study of memory deficits and cognitive disorders; or of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising using as a probe at least one SR1 selective compound or radioligand of the general formula III?, or IV?:

Abstract: Saxitoxin analogue compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogues, methods of imaging, methods of treatment, including methods of treating pain, are provided. Saxitoxin (STX), gonyautoxin (GTX), and zetekitoxin, and variant STX compounds bind to sodium channels and are effective to reduce or block flow of sodium ions through such channels. Such channel block affects nerve and muscle action, and may be effective to reduce or block pain sensations, relax muscles, reduce muscle spasm, and reduce wrinkles. STX analogue binding to sodium channels may also be useful to locate, image, or mark sodium channels, and so be useful in studying sodium channels and sodium channel disorders, and in the diagnosis and treatment of patients suffering from sodium channel disorders. In embodiments, the variant STX compounds include conjugates having increased serum half-life as compared to STX when administered to a subject.

Abstract: Saxitoxin analog compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogs, methods of imaging, methods of treatment, including methods of treating pain, are provided. Saxitoxin (STX), gonyautoxin (GTX), and zetekitoxin, and variant STX compounds bind to sodium channels and are effective to reduce or block flow of sodium ions through such channels. Such channel block affects nerve and muscle action, and may be effective to reduce or block pain sensations, relax muscles, reduce muscle spasm, and reduce wrinkles. STX analog binding to sodium channels may also be useful to locate, image, or mark sodium channels, and so be useful in studying sodium channels and sodium channel disorders, and in the diagnosis and treatment of patients suffering from sodium channel disorders. In embodiments, the variant STX compounds include conjugates having increased serum half-life as compared to STX when administered to a subject.

Abstract: A method for localizing and quantifying S1R role in nociceptive processing; for providing a guide to providing an analgesic therapy; of using an S1R selective ligand as a biomarker for pathphysiological study of memory deficits and cognitive disorders; or of detecting increased S1R density at the site of nerve injury arising from neuropathic pain comprising using as a probe at least one SR1 selective compound or radioligand of the general formula III?, or IV?:

Abstract: Certain embodiments of the present invention provide methods and systems for synchronizing a view of a patient image with an atlas image. Certain embodiments provide a method for synchronizing a patient image with an atlas image. The method includes retrieving an image atlas including at least one atlas image, registering an atlas image to a patient image and synchronizing a view of the atlas image to a view of the patient image. In certain embodiments, the method further includes registering a plurality of atlas images to a plurality of patient images. In certain embodiments, the step of synchronizing further includes synchronizing at least one of orientation, zoom level, window level and pan of the atlas image to the patient image.

Abstract: Methods and apparatus to classify reports are disclosed herein. An example method includes determining a type of an examination associated with a report; obtaining an identification of a person associated with the report; using the identification to determine whether the person associated with the report is specialized in the type of the examination; when the person associated with the report is specialized in the type of the examination, classifying the report as associated with a specialist; when the person associated with the report is unspecialized in the type of the examination, classifying the report as associated with a non-specialist; and presenting a document consumer with an indication of the classification of the report.

Abstract: Certain embodiments of the present invention provide methods and systems for synchronizing a view of a patient image with an atlas image. Certain embodiments provide a method for synchronizing a patient image with an atlas image. The method includes retrieving an image atlas including at least one atlas image, registering an atlas image to a patient image and synchronizing a view of the atlas image to a view of the patient image. In certain embodiments, the method further includes registering a plurality of atlas images to a plurality of patient images. In certain embodiments, the step of synchronizing further includes synchronizing at least one of orientation, zoom level, window level and pan of the atlas image to the patient image.

Abstract: Certain embodiments of the present invention provide methods and systems for synchronizing a view of a patient image with an atlas image. Certain embodiments provide a method for synchronizing a patient image with an atlas image. The method includes retrieving an image atlas including at least one atlas image, registering an atlas image to a patient image and synchronizing a view of the atlas image to a view of the patient image. In certain embodiments, the method further includes registering a plurality of atlas images to a plurality of patient images. In certain embodiments, the step of synchronizing further includes synchronizing at least one of orientation, zoom level, window level and pan of the atlas image to the patient image.

Abstract: Briefly described, embodiments of the present disclosure relate to methods and compositions for imaging pain and/or stress in a subject and methods and compositions for treating associated conditions. In particular, the present disclosure relates to the use of labeled compounds to provide objective diagnosis of pain and/or stress, for imaging regions associated with pain and/or stress, and for treating pain in a subject.

Abstract: Briefly described, embodiments of the present disclosure relate to methods and compositions for imaging pain and/or stress in a subject and methods and compositions for treating associated conditions. In particular, the present disclosure relates to the use of labeled compounds to provide objective diagnosis of pain and/or stress, for imaging regions associated with pain and/or stress, and for treating pain in a subject.

Abstract: Saxitoxin analogue compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogues, methods of imaging, methods of treatment, including methods of treating pain, are provided. Saxitoxin (STX), gonyautoxin (GTX), and zetekitoxin, and variant STX compounds bind to sodium channels and are effective to reduce or block flow of sodium ions through such channels. Such channel block affects nerve and muscle action, and may be effective to reduce or block pain sensations, relax muscles, reduce muscle spasm, and reduce wrinkles. STX analogue binding to sodium channels may also be useful to locate, image, or mark sodium channels, and so be useful in studying sodium channels and sodium channel disorders, and in the diagnosis and treatment of patients suffering from sodium channel disorders. In embodiments, the variant STX compounds include conjugates having increased serum half-life as compared to STX when administered to a subject.

Abstract: Certain embodiments of the present invention provide a system for the identification and retrieval of relevant archived medical information. The system includes a user interface component and a processing component. The user interface component is adapted to determine a key, which includes one or more key values. The key values may represent one or more anatomical feature of a patient. The processing component is adapted to aggregate data based at least in part on the key values. The system may also include a searchable database containing relevant archived medical information. The system may also include a display device and a storage device adapted to, respectively, display and store data retrieved from the database.

Abstract: Certain embodiments of the present invention provide methods and systems for synchronizing a view of a patient image with an atlas image. Certain embodiments provide a method for synchronizing a patient image with an atlas image. The method includes retrieving an image atlas including at least one atlas image, registering an atlas image to a patient image and synchronizing a view of the atlas image to a view of the patient image. In certain embodiments, the method further includes registering a plurality of atlas images to a plurality of patient images. In certain embodiments, the step of synchronizing further includes synchronizing at least one of orientation, zoom level, window level and pan of the atlas image to the patient image.

Abstract: Briefly described, embodiments of the present disclosure relate to methods and compositions for imaging pain and/or stress in a subject and methods and compositions for treating associated conditions. In particular, the present disclosure relates to the use of labeled compounds to provide objective diagnosis of pain and/or stress, for imaging regions associated with pain and/or stress, and for treating pain in a subject.

Abstract: Certain embodiments of the present invention provide a method of coordinating scheduling including: evaluating patient associated information corresponding to a patient having a scheduled examination; evaluating healthcare service provider associated information corresponding to at least one healthcare service provider; predicting an efficiency for one of the at least one healthcare service provider performing the scheduled examination based at least in part on the patient associated information and the healthcare service provider associated information; and adjusting a state of a coordination indicator based at least in part on the efficiency.