Patents by Inventor Sandor Batori
Sandor Batori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7176213Abstract: The present invention relates to adenosine A3 receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containings them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and (III) and to the preparation thereof.Type: GrantFiled: December 17, 2002Date of Patent: February 13, 2007Assignee: Sanofi-AventisInventors: Péter Arányi, László Balázs, Mária Balogh, Sándor Bátori, Kinga Boér, Katalin Gerber, Zoltán Kapui, Endre Mikus, Geza Tímári, T. Nagy Lajos, Katalin Urbán-Szabó, Judit Vargáné Szeredi
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Publication number: 20070021459Abstract: The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.Type: ApplicationFiled: June 21, 2006Publication date: January 25, 2007Applicant: SANOFI-AVENTISInventors: Michel ALETRU, Peter ARANYI, Maria BALOGH, Sandor BATORI, Judit BENCE, Philippe BOVY, Zoltan KAPUI, Endre MIKUS, Claudie NAMANE, Christophe PHILIPPO, Tibor SZABO, Zsuzsanna TOMOSKOZI, Katalin URBAN-SZABO
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Publication number: 20060276487Abstract: The present invention relates to the novel compounds of the general formula (I) possessing dipeptidyl peptidase IV enzyme inhibitory activity, pharmaceutical compositions thereof, methods of using said compounds, processes for their preparation and intermediates of the general formulae (II), (IV), (V), (VII), (VIII) and (IX).Type: ApplicationFiled: February 28, 2006Publication date: December 7, 2006Applicant: Sanofi-aventisInventors: Peter Aranyi, Imre Bata, Sandor Batori, Eva Boronkay, Philippe Bovy, Zoltan Kapui, Edit Susan, Tibor Szabo, Katalin Urban-Szabo, Marton Varga
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Publication number: 20060211689Abstract: The present invention relates to an adenosine A3 receptor ligand of the general formula (I), within those preferably to the antagonists, including a salt, solvate or isomer (tautomer, desmotrop, and optically active isomer) thereof, to a pharmaceutical composition containing the ligand, to the use of the ligand, to its preparation, and intermediates of the ligand of the general formula (II?), (III?), (IV?), (V?), (VI?), (VII?), (VIII?) and (XIII?) and their preparation.Type: ApplicationFiled: January 31, 2006Publication date: September 21, 2006Applicant: sanofi-aventis U.S. LLCInventors: Peter Aranyi, Sandor Batori, Geza Timari, Kinga Boer, Zoltan Kapui, Endre Mikus, Katalin Urban-Szabo, Katalin Gerber, Judit Vargane Szeredi, Michel Finet
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Patent number: 6969723Abstract: Compounds of general formula (I), wherein R4 and R5 stand for hydrogen atom or form together an 1,3-butadienyl group, optionally substituted by a methylenedioxy group or one or more straight or branched C1-4 alkyl group, straight or branched C1-4 alkoxy group, hydroxy group or halogen atom; are strong adenosine A3 receptor ligands preferably antagonists.Type: GrantFiled: May 29, 2002Date of Patent: November 29, 2005Assignee: Sanofi - AventisInventors: Peter Arányi, László Balázs, Mária Balogh, Imre Bata, Sándor Bátori, Lajos T. Nagy, Geza Tímári, Kinga Boér, Olivier Finance, Zoltán Kapui, Endre Mikus, Zsuzsanna Szamosvölgyi, Gábor Szeleczky, Katalin Urbán-Szabó
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Publication number: 20050234056Abstract: This invention is directed to a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, Z, m, n, o, p and r are as defined herein, its preparation, pharmaceutical composition and use as an adenosine A3 receptor ligand preferably an antagonist.Type: ApplicationFiled: May 16, 2005Publication date: October 20, 2005Applicant: sanofi-aventisInventors: Peter Aranyi, Laszlo Balazs, Maria Balogh, Sandor Batori, Lajos Nagy, Geza Timari, Kinga Boer, Zoltan Kapui, Endre Mikus, Katalin Gerber, Judit Vargane Szeredi, Katalin Szabo, Erzsebet Walcz
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Publication number: 20050153973Abstract: Heterocyclic amides useful as inhibitors of dipeptylpeptidase-IV (DPP-IV) enzyme, process for the preparation thereof and intermediates therefore.Type: ApplicationFiled: June 11, 2003Publication date: July 14, 2005Inventors: Peter Aranyl, Laszlo Balazs, Imre Bata, Sandor Batori, Eva Boronkay, Zoltan Kapui, Edit Susan, Tibor Szabo, Lajos Nagy, Katalin Urban-Szabo, Marton Varga
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Publication number: 20050130981Abstract: The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.Type: ApplicationFiled: March 4, 2003Publication date: June 16, 2005Inventors: Peter Aranyl, Laszlo Balazs, Imre Bata, Sandor Batori, Eva Boronkay, Philippe Bovy, Karoly Kanai, Zoltan Kapui, Edit Susan, Tibor Szabo, Lajos Nagy, Katalin Urban-Szabo, Marton Varga
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Publication number: 20050124648Abstract: The present invention relates to adenosine A-3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and theirs salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.Type: ApplicationFiled: December 17, 2002Publication date: June 9, 2005Inventors: Peter Aranyi, Laszlo Balazs, Sandor Batori, Judit Bence, Kinga Boer, Felix Hadju, Zoltan Kapui, Endre Mikus, Tibor Szabo, Lajos T. Nagy, Geza Timari, Katalin Urban-Szabo, Erzsebet Walcz
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Publication number: 20050070566Abstract: The present invention relates to adenosine A3 receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containings them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and (heir salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and (III) and to the preparation thereof.Type: ApplicationFiled: December 17, 2002Publication date: March 31, 2005Inventors: Peter Aranyl, Laszlo Balazs, Maria Balogh, Sandor Batori, Kinga Boer, Katalin Gerber, Zoltan Kapui, Endre Mikus, Geza Timari, T. Lajos, Katalin Urban-Szabo, Judit Vargane Szeredi
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Publication number: 20040186133Abstract: Compounds of general formula (I), wherein R4 and R5 stand for hydrogen atom or form together an 1,3-butadienyl group, optionally substituted by a methylenedioxy group or one or more straight or branched C1-4 alkyl group, straight or branched C1-4 alkoxy group, hydroxy group or halogen atom; are strong adenosine A3 receptor ligands preferably antagonists.Type: ApplicationFiled: May 13, 2004Publication date: September 23, 2004Inventors: Peter Aranyl, Laszlo Balazs, Maria Balogh, Imre Bata, Sandor Batori, Lajos T. Nagy, Geza Timari, Kinga Boer, Olivier Finance, Zoltan Kapul, Endre Mikus, Zsuzsanna Szamosvolgyi, Gabor Szeleczky, Katalin Urban-Szabo
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Publication number: 20030114449Abstract: Orally active compounds of general formula (I) wherein R1 is methyl, ethyl or 2-morpholino-ethyl group, R2 is piperidino, morpholino or 4-methyl-piperazinyl group, n is 2 or 3 and their salts, solvates and hydrates.Type: ApplicationFiled: October 7, 2002Publication date: June 19, 2003Inventors: Peter Aranyi, Sandor Batori, Stephane Dessilla, Istvan Hermecz, Zoltan Kapui, Ferenc Levai, Endre Mikus, Marc Pascal, Lajos T. Nagy, Bruno Simonot, Katalin Urban Szabo, Marton Varga, Lelle Vasvarine Debreczy
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Patent number: 6191161Abstract: The present invention relates to new prolylendopeptidase inhibitors of general formula (I).Type: GrantFiled: April 17, 1998Date of Patent: February 20, 2001Assignee: Chinoin Gyogyszer es VegyeszetiInventors: Károly Kánai, Sándor Erdö, Andrea Szappanos, Judit Bence, István Hermecz, Györgyné Szvoboda, Sándor Bátori, Gergely Héja, Mariá Balogh, Ágnes Horváth, Judit Sipos, Bodor Veronika Bártáne, Zsolt Párkányi, Viktor Lakics, Péter Molnár
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Patent number: 4871846Abstract: A process for the preparation of condensed as-triazinium derivatives of the formula I ##STR1## and isomers thereof, wherein R.sub.1 inter alia is an alkyl group, R.sub.2 inter alia is hydrogen or an alkyl group and R.sub.3 is hydrogen and where Z is a group of the formula a or b ##STR2## which comprises reacting a compound of the formula II ##STR3## where Y is a group of the formula c or d ##STR4## with a compound of the formula IIaNH.sub.2 --CO--R.sub.2 (IIa)in the presence of a dehydrating agent. The advantage of the process is that it consists of fewer reaction steps and provides higher yields than the known methods. The compounds of formula I are pharmaceutically active known derivatives.Type: GrantFiled: April 28, 1987Date of Patent: October 3, 1989Assignee: EGIS GyogyszergyarInventors: Sandor Batori, Gyorgy Hajos, Andras Messmer, Pal Benko, Laszlo Pallos, Lujza Petocz, Katalin Grasser, Ibolya Kosoczky, Eniko Szirt nee Kiszelly
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Patent number: 4753938Abstract: The invention relates to new compounds of the general Formula I ##STR1## and isomers thereof wherein R.sub.1 is C.sub.1-10 alkyl, C.sub.3-6 cycloalkyl or phenyl, naphthyl or phenyl-(C.sub.1-4 alkyl), wherein the aryl ring of the three latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy substituent(s);R.sub.2 stands for hydrogen, halogen, hydroxy, oxo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenyl or naphthyl, wherein the two latter groups may optionally bear one or more halogen, nitro, trifluoromethyl, amino, hydroxy, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy substituent(s);R.sub.3 represents hydrogen, hydroxy or C.sub.1-4 alkoxy;Z is buta-1,3-dienyl or a group of the general Formula (a) ##STR2## or (b) ##STR3## and X is hydrogen or halogen.The compounds of the general Formula I possess useful pharmacological properties, particularly antidepressant and antiarrhythmial effect.Type: GrantFiled: October 15, 1985Date of Patent: June 28, 1988Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Andras Messmer, Sandor Batori, Gyorgy Hajos, Pal Benko, Laszlo Pallos, Lujza Petocz, Katalin Grasser, Eniko Szirt nee Kiszelly
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Patent number: 4697013Abstract: A one step process for the preparation of compounds having antidepressant activity of the formula I ##STR1## and isomers thereof, wherein R.sub.1, R.sub.2, Z and A.sup.- have the meanings indicated in the claims, which process comprises: heating a compound of the formula II ##STR2## wherein Z, A.sup.-, R.sub.1 and R.sub.2 have the meanings set out in the claims and R.sub.3 stands for hydrogen or C.sub.1-4 alkyl, in the presence of a dehydrating agent to split off a compound of the formula R.sub.3 OH. The invention is also directed to compounds of the formula I, wherein R.sub.2 is halogen and to compositions containing a compound of the formula I which exhibit antidepressant activity.Type: GrantFiled: September 20, 1984Date of Patent: September 29, 1987Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Andras Messmer, Sandor Batori, Gyorgy Hajos, Pal Benko, Laszlo Pallos, Lujza Petocz, Grasser Katalin, Ibolya Kosoczky
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Patent number: 4602018Abstract: The invention relates to new condensed as-triazine derivatives of the general Formula I ##STR1## and isomers thereof (wherein R.sub.1 stands for C.sub.1-10 alkyl or phenyl or naphthyl, wherein the two latter groups may be optionally substituted by one or more halogen, nitro, amino, hydroxy, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy substituent(s);R.sub.2 is hydrogen, C.sub.1-4 alkyl, hydroxy, halogen or phenyl or naphthyl, wherein the two latter groups may be optionally substituted by one or more halogen, nitro, amino, hydroxy, C.sub.1-4 alkyl and/or C.sub.1-4 alkoxy substituent(s);R.sub.3 represents hydrogen or C.sub.1-4 alkyl;Z is buta-1,3-dienyl or a group of the Formula (a) ##STR2## and A.sup.- is an anion).The compounds of the general Formula I possess useful pharmacological properties, particularly antiarrhythmial and antidepressant effect.Type: GrantFiled: September 20, 1984Date of Patent: July 22, 1986Assignee: Egyt Gyogyszevegyeszeti GyarInventors: Andras Messmer, Sandor Batori, Gyorgy Hajos, Pal Benko
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Patent number: 4419355Abstract: The invention relates to new condensed as-triazine derivatives of the general formula (I) ##STR1## wherein Z represents a buta-1,3-dienyl group or a group of the formula (a), (b), (c) or (d) ##STR2## R.sub.1 denotes a C.sub.1-10 alkyl group, an oxo group or a C.sub.6-10 aryl or C.sub.6-10 aryl-(C.sub.1-3 alkyl) group optionally substituted by one or more identical or different substituents selected from the group consisting of amino, nitro, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy and halogen,R.sub.2 stands for hydrogen, C.sub.1-10 alkyl or amino,R.sub.3 represents hydrogen, C.sub.1-10 alkyl or C.sub.6-10 aryl or C.sub.6-10 aryl-(C.sub.1-3 alkyl) optionally substituted by one or more identical or different substituents selected from the group consisting of nitro, amino, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy and halogen,X.sup.- denotes an anion, andn is 0 or 1,with the proviso that if n is O, R.sub.1 is other than an oxo group and R.sub.1 ' and R.sub.Type: GrantFiled: July 16, 1981Date of Patent: December 6, 1983Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Ibolya Kosoczky, Eva Toncsev, nee Ravasz, Pal Benko, Laszlo Pallos, Lujza Petocz, Sandor Batori, Gyorgy Hajos, Andras Messmer, Katalin Grasser
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Patent number: 4320127Abstract: The invention relates to new pyrido[3,2-e]-as-triazine derivatives of the formula I and pharmaceutically acceptable acid addition salts thereof, ##STR1## wherein R.sub.1 stands for a C.sub.1-20 alkyl-carbonyl group, halogen-C.sub.1-4 alkyl-carbonyl, benzoyl, phenyl-C.sub.1-4 alkyl-carbonyl, or pyridyl-carbonyl group;R.sub.2 is a hydrogen atom or a C.sub.1-4 alkyl-carbonyl group; or R.sub.1 and R.sub.2 form together with the adjacent nitrogen atoms a pyrazole-2,4-dione ring which carries a C.sub.1-6 alkyl substituent in position 3;R.sub.3 is a hydrogen atom, a C.sub.1-20 alkyl, phenyl, phenyl-C.sub.1-3 alkyl, furyl or pyridyl group or a phenyl group optionally substituted by one to three C.sub.1-4 alkoxy-groups.The compounds of the formula I are prepared by acylating the respective 1,2-un-substituted 1,2-dihydropyrido [3,2-e]-as-triazine derivatives. The new compounds exert valuable effects on the central nervous system and possess analgesic, antiphlogistic effects, and can be applied to advantage in therapy.Type: GrantFiled: May 23, 1980Date of Patent: March 16, 1982Assignee: Edyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Andras Messmer, Gyorgy Hajos, Sandor Batori, Lujza Petocz, Iboly Kosoczky, Peter Gorog