Patents by Inventor Sandor Eckhardt

Sandor Eckhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10258598
    Abstract: The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field. A novel tumor manifestation suppression (TMS) regulation in a mammalian brain is recognized. The invention relates to compounds, pharmaceutical preparations, in particular medicaments for use in the prevention and treatment of cancer, in particular suppression of tumor manifestation based on said TMS regulation as well as methods for the same.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: April 16, 2019
    Assignees: Semmelweis University, Fujimoto Co. Ltd.
    Inventors: József Knoll, Ildikó Miklya, Péter Ferdinandy, Dezso Schuler, Zsuzsanna Schaff, Sándor Eckhardt
  • Patent number: 10258599
    Abstract: The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field. A novel tumor manifestation suppression (TMS) regulation in a mammalian brain is recognized. The invention relates to compounds, pharmaceutical preparations, in particular medicaments for use in the prevention and treatment of cancer, in particular suppression of tumor manifestation based on said TMS regulation as well as methods for the same.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: April 16, 2019
    Assignees: Semmelweis University, Fujimoto Co. Ltd.
    Inventors: József Knoll, Ildikó Miklya, Péter Ferdinandy, Dezso Schuler, Zsuzsanna Schaff, Sándor Eckhardt
  • Publication number: 20170340582
    Abstract: The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field. A novel tumour manifestation suppression (TMS) regulation in a mammalian brain is recognized. The invention relates to compounds, pharmaceutical preparations, in particular medicaments for use in the prevention and treatment of cancer, in particular suppression of tumor manifestation based on said TMS regulation as well as methods for the same.
    Type: Application
    Filed: December 7, 2015
    Publication date: November 30, 2017
    Inventors: József KNOLL, Ildikó MIKLYA, Péter FERDINANDY, Dezso SCHULER, Zsuzsanna SCHAFF, Sándor ECKHARDT
  • Publication number: 20170319535
    Abstract: The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field. A novel tumour manifestation suppression (TMS) regulation in a mammalian brain is recognized. The invention relates to compounds, pharmaceutical preparations, in particular medicaments for use in the prevention and treatment of cancer, in particular suppression of tumor manifestation based on said TMS regulation as well as methods for the same.
    Type: Application
    Filed: December 7, 2015
    Publication date: November 9, 2017
    Inventors: József KNOLL, Ildikó MIKLYA, Péter FERDINANDY, Dezso SCHULER, Zsuzsanna SCHAFF, Sándor ECKHARDT
  • Patent number: 4757077
    Abstract: The invention relates to novel bis-indole derivatives of the general formula (I) ##STR1## wherein R.sub.1 stands for a hydrogen atom or an acetyl group;R.sub.2 stands for a hydrogen atom;R.sub.3 means an ethyl group of .alpha.-position; orR.sub.2 and R.sub.3 together represent an oxygen bridge;R.sub.4 represents an ethyl or hydroxyl group of .beta.-position; andR.sub.5 stands for a hydrogen atom or a hydroxyl group;A represents a C.sub.1-10 straight-chain or C.sub.3-10 branched-chain alkyl group, hydroxy-alkyl, acetyl-alkyl, benzyl, C.sub.3-6 alkenyl or alkynyl or C.sub.5-7 cycloalkyl group or an aromatic group or a heteroaromatic group containing one nitrogen or one oxygen atom, andX stands for oxygen or sulphur atom,as well as their acid addition salts and pharmaceutical preparations containing these compounds.Further on, the invention relates to a process for preparing these compounds and preparations.
    Type: Grant
    Filed: June 12, 1986
    Date of Patent: July 12, 1988
    Assignee: Richter Gedeon Vegyeszeti Gyar R.T.
    Inventors: Csaba Szantay, Lajos Szabo, Katalin Honty, Tibor Keve, Tibor Acs, Sandor Eckhardt, Janos Sugar, Zsuzsa Somfai, Eva Ivan, Zsuzsa Kneffel
  • Patent number: 4753948
    Abstract: The invention relates to novel furfuryl derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for a hydrogen atom or an acetyl group,R.sub.2 stands for a hydroxyl or ethyl group of.beta.-position;R.sub.3 means an ethyl group of .alpha.-position;R.sub.4 represents a hydrogen atom; orR.sub.3 and R.sub.4 together represent an oxygen bridge; andB stands for a hydroxyl of an O-acyl group, as well as their acid addition salts and pharmaceutical preparations containing these compounds. Further on, the invention relates to a process for preparing these compounds and preparations.The compounds of the general formula (I) show a cytostatic activity with less toxicity than that of the commerically available known vinblastine-type bis-indole alkaloid drugs.
    Type: Grant
    Filed: June 12, 1986
    Date of Patent: June 28, 1988
    Assignee: Richter Gedeon Vegyeszeti Gyar R.T.
    Inventors: Csaba Szantay, Lajos Szabo, Katalin Honty, Tibor Keve, Tibor Acs, Sandor Eckhardt, Janos Sugar, Zsuzsa Somjai, Eva Ivan, Zsuzsa Kneffel
  • Patent number: 4746665
    Abstract: The invention relates to novel nitro derivatives of the general formula (I) ##STR1## wherein R.sub.1 stands for a methyl or a formyl group;R.sub.2 stands for a hydroxy or ethyl group of .beta.-position;R.sub.3 means an ethyl group of .alpha.-position;R.sub.4 represents a hydrogen atom; orR.sub.3 and R.sub.4 together represent an oxygen bridge or a double bond;R.sub.5, R.sub.6 and R.sub.7 stand for a nitro group or hydrogen atom, with the proviso that simultaneously only one of them may stand for hydrogen atom; andY stands for --N.dbd. when R.sub.5 stands for a nitro group; whereasY stands for --NH-- when R.sub.5 stands for a hydrogen atom and a valence bond exists between the C.sub.2, and C.sub.7, atoms,as well as their acid addition salts and pharmaceutical preparations containing these compounds.Further on, the invention relates to a process for preparing these compounds and preparations.
    Type: Grant
    Filed: June 12, 1986
    Date of Patent: May 24, 1988
    Assignee: Richter Gedeon Vegyeszeti Gyar
    Inventors: Csaba Szantay, Lajos Szabo, Katalin Honty, Tibor Keve, Tibor cs, Sandor Eckhardt, Janos Sugar, Zsuzsa Somfai, Eva Ivan, Zsuzsa Kneffel
  • Patent number: 4490378
    Abstract: The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl andR.sup.3 is .alpha.-ethyl; orR.sup.4 is hydrogen andR.sup.3 is .beta.-ethyl;R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a --CH.sub.2 --O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety;R.sup.1 is methoxy andR.sup.2 is acetyl, provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl,R.sup.4 is other than ethyl.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: December 25, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Dancsi, Tibor Keve, Gyorgy Fekete, Eszter Dezseri, Sandor Gorog, Tibor cs, Csaba Szantay, Lajos Szabo, Katalin Honty, Sandor Eckhardt, Ivan Hindi, Sandor Kerpel-Fronius, Zsuzsanna Relle nee Somfa, Janos Sugar
  • Patent number: 4419522
    Abstract: The invention relates to new hexitols having the general formula (I) and (II), ##STR1## wherein the hexitol skeleton is dulcitol, mannitol or iditol,X represents halogen, preferably bromine,R is a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains a free carboxy group, andR.sup.1 is hydrogen, a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains a free carboxy group, a saturated or unsaturated C.sub.2-10 alkylcarbonyl group, a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains an alkoxycarbonyl group, or a saturated or unsaturated C.sub.8-10 aralkylcarbonyl group,and salts of these compounds. The new compounds according to the invention have tumor-inhibiting affects.The above compounds are prepared according to the invention so that(a) a compound of the general formula (IX), whereinthe hexitol skeleton is dulcitol, mannitol or iditol,Q is a saturated or unsaturated C.sub.
    Type: Grant
    Filed: October 26, 1981
    Date of Patent: December 6, 1983
    Assignee: Chinoin Gyogyszer Vegyeszeti Termekek Gyara Rt.
    Inventors: Ilona Elekes, Laszlo Institoris, Kalman Medzihradsz, Laszlo tvos, Hedvig Medzihradszky-Schweiger, Katalin De Gleria, Janos Sugar, Somfai Relle, Sandor Eckhardt, Ivan Hidy, Sandor Kerpel-Fronius
  • Patent number: 4410459
    Abstract: The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl andR.sup.3 is .alpha.-ethyl; orR.sup.4 is hydrogen andR.sup.3 is .beta.-ethyl;R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a -CH.sub.2 -O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety;R.sup.1 is methoxy andR.sup.2 is acetyl,provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl, R.sup.4 is other than ethyl.
    Type: Grant
    Filed: August 17, 1981
    Date of Patent: October 18, 1983
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Dancsi, Tibor Keve, Lajos Szabo, Katalin Honty, Sandor Eckhardt, Ivan Hindi, Sandor Kerpel-Fronius, Gyorgy Fekete, Eszter Dezseri, Sandor Gorog, Tibor Acs, Csaba Szantay, Zsuzsanna Relle nee Somfai, Janos Sugar
  • Patent number: 4237273
    Abstract: The invention relates to bis(nitrosoureido)-polyol derivatives of general formula IB.sub.1 --A--B.sub.2 (I)whereinA stands for an open chain polyol comprising 4 to 6 carbon atoms or a six-membered cyclic polyol, andB.sub.1 and B.sub.2 being attached to two different carbon atoms of the chain A, are identical or different, and stand for a group of general formula II ##STR1## wherein X stands for a halogen atom andY and Z stand for a hydrogen atom or a nitroso group, with the restriction, that in B.sub.1 and B.sub.2 Y and Z must be different.The above compounds possess valuable cytostatic activity.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: December 2, 1980
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Tibor Horvath, Endre Csanyi, Sandor Eckhardt, Emilia Kiraly nee Vida
  • Patent number: 4209443
    Abstract: A mixture of minor diindole alkaloids from Vinca-containing vinblastine and 4-deacetoxy-vinblastine vines, are separated by subjecting the mixture to a deacetylation to correct the vinblastine to deacetyl-vinblastine prior to chromatographic separation of said mixture in a single stage.
    Type: Grant
    Filed: March 1, 1978
    Date of Patent: June 24, 1980
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Karola Jovanovics, Lajos Dancsi, Sandor Eckhardt, Csaba Lorincz, Janos Sugar, Zsuzsa Relle nee Somfai, Kalman Szasz, Jozsef Tamas, Aron Szollosy