Patents by Inventor Sandor Gorog

Sandor Gorog has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4410459
    Abstract: The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl andR.sup.3 is .alpha.-ethyl; orR.sup.4 is hydrogen andR.sup.3 is .beta.-ethyl;R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a -CH.sub.2 -O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety;R.sup.1 is methoxy andR.sup.2 is acetyl,provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl, R.sup.4 is other than ethyl.
    Type: Grant
    Filed: August 17, 1981
    Date of Patent: October 18, 1983
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Dancsi, Tibor Keve, Lajos Szabo, Katalin Honty, Sandor Eckhardt, Ivan Hindi, Sandor Kerpel-Fronius, Gyorgy Fekete, Eszter Dezseri, Sandor Gorog, Tibor Acs, Csaba Szantay, Zsuzsanna Relle nee Somfai, Janos Sugar
  • Patent number: 4390625
    Abstract: The invention relates to a new method for controlling the level and distribution of alkaloids produced by Claviceps purpurea variant strains capable of producing primarily ergocornine, .alpha.-ergocryptine and .beta.-ergocryptine under saprophytic conditions. According to the invention a compound of the biosynthesis path of isoleucine or a compound which promotes the formation of isoleucine by biochemical control is added to the fermentation broth. In other respects fermentation is performed under conditions known per se.By the method of the invention the ratio of .alpha.- and .beta.-ergocryptine formed in the fermentation broth can be adjusted to the optimum value.
    Type: Grant
    Filed: February 6, 1981
    Date of Patent: June 28, 1983
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Eva Udvardy Nagy nee Cserey Pechany, Miklos Budai, Gyorgy Fekete, Sandor Gorog, Bulcsu Herenyi, Geza Wack, Karoly Zalai
  • Patent number: 4310528
    Abstract: A process for the preparation of diindole-alkaloids, especially new compounds corresponding to vinblastine or leurosine, in which the N-methyl group is replaced by an N--CH.sub.2 --O--R group wherein R is lower alkyl, having antitumor properties. The starting materials are subjected to oxidation by chromic acid or an alkali metal dichromate at temperatures from -90.degree. C. to -30.degree. C. and preferably below -45.degree. C. where the new compounds are to be produced, a lower alkanol being present in this case.
    Type: Grant
    Filed: April 8, 1980
    Date of Patent: January 12, 1982
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Karola Jovanovics, Sandor Gorog
  • Patent number: 4298525
    Abstract: A process for the preparation of diindolealkaloids, especially new compounds corresponding to vinblastine or leurosine, in which the N-methyl group is replaced by an N--CH.sub.2 --OC.sub.2 H.sub.5 group having antitumor properties. The starting compounds are subjected to oxidation by chromic acid or an alkali metal dichromate at temperatures from -90.degree. C. to -30.degree. C. but preferably below about -45.degree. C. when the new compounds are to be produced, ethanol being present in this case.
    Type: Grant
    Filed: July 27, 1979
    Date of Patent: November 3, 1981
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Karola Jovanovics, Sandor Gorog
  • Patent number: 4221739
    Abstract: Compounds of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 each is saturated or unsaturated, straight-chained or branched alkyl phenyl, alkylphenyl or saturated or unsaturated cycloalkyl;but when R.sub.1 is methyl, R.sub.2 is a group other than methyl, are prepared by reacting a compound of the formula (II), ##STR2## wherein X is halogen, with a secondary amine of the formula (III),R.sub.1 --NH--R.sub.2 (III)The new compounds of the formula (I), as well as their pharmaceutically acceptable acid addition salts are active primarily in the induction of liver microsomal enzyme, but also possess antipyretic activity.
    Type: Grant
    Filed: August 12, 1975
    Date of Patent: September 9, 1980
    Assignee: Richter Gedeon Vegyeszeti Gyar R.T.
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szabolos Szeberenyi, Laszlo Szporny, Sandor Gorog, Csilla Meszaros
  • Patent number: 4201723
    Abstract: New compounds of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 each is a saturated or unsaturated, straight-chained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, orR.sub.1 and R.sub.2 together with the adjacent nitrogen atom forms a substituted or unsubstituted heterocyclic group with or without a further oxygen or nitrogen heteroatom, andR.sub.3 is hydrogen or an acyl group derived from a C.sub.1-18 carboxylic acid. The compounds are prepared by reducing the corresponding nitro compounds of the formula (II) ##STR2## and optionally acylating the obtained product. The compounds of the formula (I) and their acid addition salts and quaternary ammonium salts are active primarily in the induction of liver microsomal enzymes, but they also possess valuable antipyretic activity and a yohimbine lethality increasing effect characteristic of antidepressants.
    Type: Grant
    Filed: June 22, 1977
    Date of Patent: May 6, 1980
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szaboles Szeberenyi, Laszlo Szporny, Sandor Gorog, Csilla Meszaros
  • Patent number: 4200636
    Abstract: The invention relates to new 3-amino-17a-aza-D-homo-5.alpha.-androstane derivatives of the general formula I ##STR1## wherein R.sub.1 represents a methylene or an >N--CH.sub.3 group, and n stands for 1 or 2, and the acid addition salts and the quaternary salts of the general formula ##STR2## thereof, wherein R.sub.2 stands for an alkyl or alkenyl group having from 1 to 4 carbon atoms, and A represents a halogen atom, provided that if R.sub.1 stands for an >N--CH.sub.3 group, R.sub.2 is attached to the nitrogen of that >N--CH.sub.3 group. The new compound possess a non-polarizing neuromuscular blocking activity and have a short activity period.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: April 29, 1980
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltan Tuba, Maria Marsai, Sandor Gorog, Katalin Biro, Egon Karpati, Laszlo Szporny
  • Patent number: 4094908
    Abstract: The invention relates to new .alpha.
    Type: Grant
    Filed: September 9, 1976
    Date of Patent: June 13, 1978
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Szabolcs Szeberenyi, Eva Palosi, Laszlo Szporny, Sandor Gorog, Csilla Meszaros
  • Patent number: 4082813
    Abstract: The invention is directed to a new substituted derivative of .alpha.-ethylnyl-benzophenone, namely, the 3-iodo-.alpha.-ethynyl-benzhydrol which has high antifungal activity.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: April 4, 1978
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Sandor Gorog, Laszlo Szporny, Eva Palosi, Szabolcz Szeberenyi
  • Patent number: 4075249
    Abstract: The new compound 3,4,5-trimethoxy-.alpha.-ethynyl benzhydrol which has been found to be an effective fungicide.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: February 21, 1978
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Edit Toth, Jozsef Torley, Sandor Gorog, Laszlo Szporny, Eva Palosi, Szabolcz Szeberenyi
  • Patent number: 4066709
    Abstract: .alpha.-ethynyl-benzhydrols, namely 2,5-dimethyl-.alpha.-ethynyl and 4-n-butyl-.alpha.-ethynyl benzhydrol, are made by reacting the starting benzophenone with acetylene in a solvent delivering no protons, in the presence of an alkali metal tertiary alcoholate, preferably potassium-ter.-butylate or potassium-tert.-amylate.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: January 3, 1978
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Sandor Gorog, Laszlo Szporny, Eva Palosi, Szabolcs Szeberenyi
  • Patent number: 4064121
    Abstract: New compounds of the general formula (I), ##STR1## wherein R.sub.1 and R.sub.2 each stand for a saturated or unsaturated, straight-chained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, orR.sub.1 and R.sub.2 together with the adjacent nitrogen atom may form an optionally substituted heterocyclic group optionally containing a further oxygen or nitrogen hetero atom,But if R.sub.1 stands for methyl, R.sub.2 may only stand for a group other than methyl, are prepared by reacting a compound of the general formula ##STR2## wherein X stands for halogen, with a secondary amine of the general formula (III),r.sub.1 --nh--r.sub.2 (iii)wherein R.sub.1 and R.sub.2 each have the same meanings as defined above.The new compounds of the general formula (I), as well as their pharmaceutical acceptable acid addition salts or quaternary ammonium salts are active primarily in the induction of liver microsomal enzyme, but they also possess antipyretic activity.
    Type: Grant
    Filed: August 12, 1975
    Date of Patent: December 20, 1977
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szaboles Szeberenyi, Laszlo Szporny, Sandor Gorog, Csilla Meszaros
  • Patent number: 4039589
    Abstract: A compound of the formula: ##STR1## wherein Z is ethyl or vinyl,R.sub.1 and R.sub.2 are hydrogen, lower alkyl, lower alkenyl or trihalomethyl,R.sub.3 and R.sub.4 are hydrogen, lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl or phenyl, andR.sub.5 is lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl, or phenyl with the proviso that where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each is hydrogen, R.sub.5 is not methyl attached to the 4-position of the benzene ring, or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof is disclosed as effective in the regulation of the liver microsomal enzyme system.
    Type: Grant
    Filed: August 8, 1974
    Date of Patent: August 2, 1977
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Szabolcs Szeberenyi, Eva Palosi, Laszlo Szporny, Sandor Gorog, Csilla Meszaros
  • Patent number: 3989701
    Abstract: New compounds of the general formula (I) ##SPC1##whereinR.sub.1 and R.sub.2 each is a saturated or unsaturated, straight-chained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, orR.sub.1 and R.sub.2 together with the adjacent nitrogen atom may form substituted or unsubstituted heterocyclic group with or without a further oxygen or nitrogen heteroatom, andR.sub.3 is hydrogen or an acyl group derived from a C.sub.1.sub.-18 carboxylic acid.The compounds are prepared by reducing the corresponding nitro compounds of the general formula (II) ##SPC2##and optionally acylating the obtained product.The compounds of the general formula (I) and their acid addition salts and quaternary ammonium salts are active primarily in the induction of liver microsomal enzyme, but they also possess valuable antipyretic activity and a yohimbine lethality increasing effect characteristic of antidepressants.
    Type: Grant
    Filed: July 3, 1974
    Date of Patent: November 2, 1976
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szaboles Szeberenyi, Laszlo Szporny, Sandor Gorog, Csilla Meszaros
  • Patent number: 3975390
    Abstract: New compounds of the general formula (I), ##SPC1##whereinR.sub.1 and R.sub.2 each stand for a saturated or unsaturated, straight-chained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, orR.sub.1 and R.sub.2 together with the adjacent nitrogen atom may form an optionally substituted heterocyclic group optionally containing a further oxygen or nitrogen hetero atom,But if R.sub.1 stands for methyl, R.sub.2 may only stand for a group other than methyl,Are prepared by reacting a compound of the general formula (II), ##SPC2##wherein X stands for halogen, with a secondary amine of the general formula (III),r.sub.1 --nh--r.sub.2 (iii)wherein R.sub.1 and R.sub.2 each have the same meanings as defined above.The new compounds of the general formula (I), as well as their pharmaceutical acceptable acid addition salts or quaternary ammonium salts are active primarily in the induction of liver microsomal enzyme, but they also possess antipyretic activity.
    Type: Grant
    Filed: August 12, 1975
    Date of Patent: August 17, 1976
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szaholes Szeberenyi, Laszlo Szporny, Sandor Gorog, Csilla Meszaros
  • Patent number: 3965179
    Abstract: The invention is a new process for the preparation of .alpha.-ethynyl-benzohydrols and of ring-substituted derivatives thereof by reacting the starting benzophenone or a ring-substituted derivative thereof with acetylene in a solvent delivering no protons, in the presence of an alkali metal tertiary alcoholate, preferably potassium-tert.-butylate or potassium-tert.-amylate. Also new substituted derivatives of .alpha.-ethynyl-benzhydrol are prepared by the invention.
    Type: Grant
    Filed: August 8, 1974
    Date of Patent: June 22, 1976
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Sandor Gorog, Laszlo Szporny, Eva Palosi, Szabolcz Szeberenyi
  • Patent number: 3957777
    Abstract: New compounds of the formula (I), ##SPC1##whereinR.sub.1 and R.sub.2 each stand for a saturated or unsaturated, straightchained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, orR.sub.1 and R.sub.2 together with the adjacent nitrogen atom form a substituted or unsubstituted heterocyclic group which can contain a further oxygen or nitrogen hetero atom,But when R.sub.1 is methyl, R.sub.2 is a group other than methyl, are prepared by reacting a compound of the formula (II), ##SPC2##wherein X stands for halogen, with a secondary amine of the general formula (III),r.sub.1 --nh--r.sub.2. (iii)the new compounds of the general formula (I), as well as their pharmaceutical acceptable acid addition salts or quaternary ammonium salts are active primarily in the induction of liver microsomal enzyme, but they also possess antipyretic activity.
    Type: Grant
    Filed: July 3, 1974
    Date of Patent: May 18, 1976
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szaboles Szeberenyi, Laszlo Szporny, Sandor Gorog, Csilla Meszaros