Patents by Inventor SANDOR GYORKE

SANDOR GYORKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered calmodulin for treatment of ryanopathies
    Patent number: 10214574
    Abstract: Compositions and methods are disclosed for altering the binding affinity of calmodulin for ryanodine receptor 2 (RyR2). As disclosed herein, these therapeutic calmodulin (TCaM) proteins can be used to correct ryanopathies by prolonging the RyR2 refractory period. Therefore, also disclosed is a method for treating a ryanopathy-associated disease in a subject that involves administering to the subject a composition comprising a TCaM disclosed herein.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: February 26, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Jonathan Paul Davis, Sandor Gyorke
  • ENGINEERED CALMODULIN FOR TREATMENT OF RYANOPATHIES
    Publication number: 20180086803
    Abstract: Compositions and methods are disclosed for altering the binding affinity of calmodulin for ryanodine receptor 2 (RyR2). As disclosed herein, these therapeutic calmodulin (TCaM) proteins can be used to correct ryanopathies by prolonging the RyR2 refractory period. Therefore, also disclosed is a method for treating a ryanopathy-associated disease in a subject that involves administering to the subject a composition comprising a TCaM disclosed herein.
    Type: Application
    Filed: April 15, 2016
    Publication date: March 29, 2018
    Inventors: JONATHAN PAUL DAVIS, SANDOR GYORKE