Patents by Inventor Sandor Karady

Sandor Karady has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the Preparation of 2,2-Disubstituted Pyrroles
    Publication number: 20070225499
    Abstract: The present invention relates to the stereoselective preparation of 2,2-disubstituted-4-carbonatepyrroles from readily available chiral starting materials. Such pyrroles are useful as intermediates in the preparation of 2,2,4-trisubstituted 2,5-dihydropyrroles, that are inhibitors of mitotic kinesins and are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The product of the process of the invention may be illustrated by the Formula (I).
    Type: Application
    Filed: April 15, 2005
    Publication date: September 27, 2007
    Inventors: Gary Javadi, Sandor Karady, Kenji Maeda, Ross Miller, Ronald Szumigala
  • Piperazine carboxamide intermediates of HIV protease inhibitors and processes for their preparation
    Publication number: 20030191121
    Abstract: Piperazine carboxamide intermediates of HIV protease inhibitors and a process for their preparation are disclosed.
    Type: Application
    Filed: August 6, 2002
    Publication date: October 9, 2003
    Inventors: Ross A. Miller, Sandor Karady, Paul J. Reider
  • Efficient synthesis of cyclopropylacetylene
    Patent number: 6072094
    Abstract: An efficient and facile process for the preparation of cyclopropylacetylene from thioanisole and cyclopropyl substituted ketones or aldehydes is disclosed.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: June 6, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Sandor Karady, Benjamin Marcune
  • Trialkylsilyl trifluoromethanesulfonate mediated .alpha.-methylenic carbon functionalization of 4-aza-5.alpha.-androstan-3-one steroids
    Patent number: 5187278
    Abstract: A novel single-pot trialkylsilyl trifluoromethanesulfonate (R.sub.3 Si-OTf) mediated process produces derivatives of 4-aza 3-keto steroids at the .alpha.-methylenic carbon through electrophilic substitution. These derivatives are useful in the preparation, through elimination of the substituent on the .alpha.-methylene carbon, of .DELTA.-1 olefin 4-aza 3-keto steroids which are potent inhibitors of 5-.alpha. reductase.
    Type: Grant
    Filed: November 1, 1991
    Date of Patent: February 16, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Anthony O. King, Kevin Anderson, Sandor Karady, Alan W. Douglas, Newton L. Abramson, Richard F. Shuman
  • Process for iodinating or brominating the .alpha.-methylenic carbon of a secondary amide
    Patent number: 5120847
    Abstract: A novel, facile, and specific process for .alpha.-iodinating or .alpha.-brominating the .alpha.-methylenic carbon of a straight chain, branched chain, or cyclic secondary amide, such as a lactam or an azasteroid, comprises reacting the amide with trialkylsilyl-X (R.sub.3 Si--X), where X is Br, I, or Cl, and R is methyl, ethyl, or n-propyl, in the presence of I.sub.2 or Br.sub.2. The .alpha.-iodo- or .alpha.-bromo-amide is useful for making the .alpha.,.beta.-unsaturated amide through dehydrohalogenation.
    Type: Grant
    Filed: August 27, 1990
    Date of Patent: June 9, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Anthony O. King, Sandor Karady, Kevin Anderson, Newton L. Abramson, Richard F. Shuman
  • Trialkylsilyl trifluoromethanesulfonate mediated .alpha.-methylenic carbon functionalization of 4-AZA-5.alpha.-androstan-3-one steroids
    Patent number: 5091534
    Abstract: A novel single-pot trialkylsilyl trifluoromethanesulfonate (R.sub.3 Si--OTf) mediated process produces derivatives of 4-aza 3-keto steroids at the .alpha.-methylenic carbon through electrophilic substitution. These derivatives are useful in the preparation, through elimination of the substituent on the .alpha.-methylene carbon, of .DELTA.-1 olefin 4-aza 3-keto steroids which are potent inhibitors of 5-.alpha. reductase.
    Type: Grant
    Filed: August 27, 1990
    Date of Patent: February 25, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Anthony O. P. King, Sandor Karady, Kevin Anderson, Alan W. Douglas, Newton L. Abramson, Richard F. Shuman
  • Process for preparing 10,11-dihydro-11-exo-hydroxy-5-methyldibenzo[a,d]cyclohepten-5,10-imine
    Patent number: 4869791
    Abstract: 10,11 Dihydro-11-exo-hydroxy-5-methyldibenzo[a,d]cyclohepten-5,10-imine is prepared in a four step synthesis which uses an electrochemical cyclization to form the 5,10-imine bridge in about a 50% yield.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: September 26, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Sandor Karady, Leonard M. Weinstock
  • Process for deblocking N-substituted .beta.-lactams
    Patent number: 4834846
    Abstract: This invention relates to a process for preparing .beta.-lactams by electrochemically deblocking N-substituting .beta.-lactams using anodic oxidation.
    Type: Grant
    Filed: December 7, 1987
    Date of Patent: May 30, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Newton L. Abramson, Sandor Karady, Edward G. Corley, Leonard M. Weinstock
  • Preparation of an enantiomer of a substituted fluorenyloxyacetic acid
    Patent number: 4704472
    Abstract: A process for direct preparation of an enantiomer of a substituted fluorenyloxyacetic acid is disclosed. The acetic acid derivative is useful for treating brain edema.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: November 3, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Robin S. E. Conn, Sandor Karady
  • Silyl, benzyl, p-nitrobenyl, or methyl esters of diazoacetate, a synthon used in the conversion of penicillin to thienamycin
    Patent number: 4525582
    Abstract: A novel synthon useful in the conversion of penicillin is a compound of the formula ##STR1## wherein R.sub.3 is a number of the group consisting of trimethyl-silyl, t-butyl dimethyl silyl, trimethyl silyl, methyl, benzyl or nitrobenzyl, and R.sub.5 is the same or different member of the group R.sub.3 is prepared by the naphthalene sulfonyl azide exchange reaction with benzyl acetoacetate, p-nitrobenzylacetoacetate, or methylacetoacetate to obtain the corresponding 2-diazo compound which is then silylated in hexamethyl-disalazine.
    Type: Grant
    Filed: January 23, 1984
    Date of Patent: June 25, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Joseph S. Amato, Sandor Karady, Leonard M. Weinstock
  • Process for preparation of alpha-alkyl amino acids
    Patent number: 4508921
    Abstract: A process for preparing .alpha.-alkyl amino acids by enantioretentive .alpha.-alkylation of .alpha.-amino acids is described. The products are bioactive compounds including some useful as therapeutic agents.
    Type: Grant
    Filed: June 28, 1984
    Date of Patent: April 2, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Joseph S. Amato, Leonard M. Weinstock, Sandor Karady
  • Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
    Patent number: 4477668
    Abstract: (+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine, and its pharmaceutically acceptable salts is useful as an anxiolytic, antidepressant, anticonvulsant, muscle relaxant and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease. The racemate of the compound is produced by a four-step synthetic process in about 65% yield from 5H-dibenzo[a,d]cyclohepten-5-one.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: October 16, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Dean R. Bender, Sandor Karady, Theresa Rothauser
  • Stereospecific synthesis of thienamycin from penicillin
    Patent number: 4444685
    Abstract: A stereospecific conversion of penicillin to thienamycin, using diisopropylamine borane and magnesium trifluoroacetate to prepare the hydroxyethyl side chain and acetoacetate dianion equivalent disilylethyl to prepare the .beta.-ketoester side chain.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: April 24, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Joseph S. Amato, Sandor Karady, Leonard M. Weinstock
  • Substituted-1,2,5-thiadiazole-1-oxide compounds, compositions and use
    Patent number: 4362726
    Abstract: Substituted-1,2,5-thiadiazole-1-oxides, their preparation and pharmaceutical use as elastase inhibitors are disclosed.
    Type: Grant
    Filed: April 24, 1981
    Date of Patent: December 7, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Joseph S. Amato, Sandor Karady, Leonard M. Weinstock
  • 3-Substituted-7-methoxy-7-amino-3-cephem-4-carboxylic acids
    Patent number: 4343937
    Abstract: Process and intermediate products useful in the preparation of cephalosporin compounds having a substituent at the 7-position in place of hydrogen are provided. The new cephalosporin compounds are active against various gram-negative and gram-positive organisms.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: August 10, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Sandor Karady, Lovji D. Cama, Meyer Sletzinger
  • Cephalosporin antibiotic compositions
    Patent number: 4342757
    Abstract: Process and intermediate products useful in the preparation of cephalosporin compounds having a substituent at the 7-position in place of hydrogen are provided. The new cephalosporin compounds are active against various gram-negative and gram-positive organisms.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: August 3, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Sandor Karady, Lovji D. Cama, Meyer Sletzinger
  • Cephalosporin antibiotics
    Patent number: 4342869
    Abstract: Process and intermediate products useful in the preparation of cephalosporin compounds having a substituent at the 7-position in place of hydrogen are provided. The new cephalosporin compounds are active against various gram-negative and gram-positive organisms.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: August 3, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Sandor Karady, Lovji D. Cama, Meyer Sletzinger
  • Cephalosporin antibiotics
    Patent number: 4338438
    Abstract: Process and intermediate products useful in the preparation of cephalosporin compounds having a substituent at the 7-position in place of hydrogen are provided. The new cephalosporin compounds are active against various gram-negative and gram-positive organisms.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: July 6, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Sandor Karady, Lovji D. Cama, Meyer Sletzinger
  • Cephalosporin antibiotics
    Patent number: 4338437
    Abstract: Process and intermediate products useful in the preparation of cephalosporin compounds having a substituent at the 7-position in place of hydrogen are provided. The new cephalosporin compounds are active against various gram-negative and gram-positive organisms.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: July 6, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Sandor Karady, Lovji D. Cama, Meyer Sletzinger
  • Cephalosporin intermediates
    Patent number: 4324890
    Abstract: Process and intermediate products useful in the preparation of cephalosporin compounds having a substituent at the 7-position in place of hydrogen are provided. The new cephalosporin compounds are active against various gram-negative and gram-positive organisms.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: April 13, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Sandor Karady, Lovji D. Cama, Meyer Sletzinger