Patents by Inventor Sandor Kerpel-Fronius

Sandor Kerpel-Fronius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-Desmethyl-N-(allyloxymethyl)-vinblastine and antileukemic and antilymphomic compositions and method of treatment
    Patent number: 4490378
    Abstract: The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl andR.sup.3 is .alpha.-ethyl; orR.sup.4 is hydrogen andR.sup.3 is .beta.-ethyl;R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a --CH.sub.2 --O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety;R.sup.1 is methoxy andR.sup.2 is acetyl, provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl,R.sup.4 is other than ethyl.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: December 25, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Dancsi, Tibor Keve, Gyorgy Fekete, Eszter Dezseri, Sandor Gorog, Tibor cs, Csaba Szantay, Lajos Szabo, Katalin Honty, Sandor Eckhardt, Ivan Hindi, Sandor Kerpel-Fronius, Zsuzsanna Relle nee Somfa, Janos Sugar
  • Hexitols containing free carboxy groups and a process for the preparation thereof
    Patent number: 4419522
    Abstract: The invention relates to new hexitols having the general formula (I) and (II), ##STR1## wherein the hexitol skeleton is dulcitol, mannitol or iditol,X represents halogen, preferably bromine,R is a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains a free carboxy group, andR.sup.1 is hydrogen, a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains a free carboxy group, a saturated or unsaturated C.sub.2-10 alkylcarbonyl group, a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains an alkoxycarbonyl group, or a saturated or unsaturated C.sub.8-10 aralkylcarbonyl group,and salts of these compounds. The new compounds according to the invention have tumor-inhibiting affects.The above compounds are prepared according to the invention so that(a) a compound of the general formula (IX), whereinthe hexitol skeleton is dulcitol, mannitol or iditol,Q is a saturated or unsaturated C.sub.
    Type: Grant
    Filed: October 26, 1981
    Date of Patent: December 6, 1983
    Assignee: Chinoin Gyogyszer Vegyeszeti Termekek Gyara Rt.
    Inventors: Ilona Elekes, Laszlo Institoris, Kalman Medzihradsz, Laszlo tvos, Hedvig Medzihradszky-Schweiger, Katalin De Gleria, Janos Sugar, Somfai Relle, Sandor Eckhardt, Ivan Hidy, Sandor Kerpel-Fronius
  • Process for preparation of cytostatic compounds
    Patent number: 4410459
    Abstract: The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl andR.sup.3 is .alpha.-ethyl; orR.sup.4 is hydrogen andR.sup.3 is .beta.-ethyl;R" is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >N.sub.a -CH.sub.2 -O-- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety;R.sup.1 is methoxy andR.sup.2 is acetyl,provided that if R.sup.3 is .alpha.-ethyl and R.sup.4 .beta.-hydroxyl, R.sup.4 is other than ethyl.
    Type: Grant
    Filed: August 17, 1981
    Date of Patent: October 18, 1983
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Lajos Dancsi, Tibor Keve, Lajos Szabo, Katalin Honty, Sandor Eckhardt, Ivan Hindi, Sandor Kerpel-Fronius, Gyorgy Fekete, Eszter Dezseri, Sandor Gorog, Tibor Acs, Csaba Szantay, Zsuzsanna Relle nee Somfai, Janos Sugar