Abstract: A needle shield assembly of the present invention includes a needle cannula having a proximal end, a distal end and a lumen therethrough. A hub having a proximal end for connecting to a medical instrument and a distal end connected to the proximal end of the needle cannula is provided. A base member is connected to the hub. An elongate needle shield includes a proximal end hingedly connected to the base member, a distal end and a longitudinal axis therebetween. The needle shield includes a longitudinal opening therein. The needle shield is capable of rotating from a first position exposing at least the distal end the needle cannula and a second position wherein the needle cannula is within the longitudinal opening of the needle shield. A sleeve having a longitudinal slot is rotatably connected to the needle shield.

Abstract: The invention relates to novel N-hydroxy-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives of the formula ##STR1## wherein A, B, D, E, G, I and R are as defined in the specification, m is 0, 1 or 2, with the proviso that:m is 0 or 2, or both G and I are hydrogen, when A is benzyl or halogen-monosubstituted benzyl group; andm is 1, when A is 2-picolyl, as well as their pharmaceutically acceptable acid addition salts. The compounds of formula (I) are useful for enhancing the tolerance of mammals (including man) against hypoxic and/or ischaemic states as well as for treating the degenerative and functional disturbances arising from hypoxic and/or ischaemic results.

Abstract: A safety needle assembly for providing secure connection of a needle cannula to a straight-site or Y-site of an intravenous fitting. The assembly includes a base portion and a protective shield disposed about the needle cannula to at least partially envelop the needle cannula within the shield. A latch is pivoted to the shield so as to releasably lock the intravenous fitting within the shield. The latch includes a pivot arm having at least one shield engaging finger member disposed to biasingly engage at least a portion of the shield, and at least one member disposed through a passageway formed in the shield to trap the intravenous fitting within the shield.

Abstract: New compounds with the ability to inhibit calcium uptake in the brains of mammals are disclosed of the Formula (I) ##STR1## wherein R.sup.1 is hydrogen, C.sub.1 to C.sub.4 alkyl, phenyl, or phenyl-C.sub.1 to C.sub.4 alkyl;one of R.sup.2 and R.sup.3 is C.sub.1 to C.sub.4 alkoxy and the other one is phenyl-C.sub.1 to C.sub.4 alkoxy optionally substituted by C.sub.1 to C.sub.4 alkyl in the aromatic nucleus; andR.sup.4 is phenyl optionally substituted by C.sub.1 to C.sub.4 alkyl in the aromatic nucleus, or their solvates, individual optically active and geometric isomers, mixtures of such isomers, as well as pharmaceutically acceptable acid addition salts thereof. The compounds of the Formula (I) are capable of inhibiting calcium uptake to brain cells and have a protective effect on hypobaric hypoxia.

Abstract: The invention is directed to novel angiotropic (angiogenic and angiostatic) steroids. They are halogenated in the 21 position. The invention is also directed to novel methods of treating gastrointestinal ulcers by the administration of the novel angiotropic (angiogenic) steroids.

Abstract: Disclosed is a method for treating ulcers of the gastrointestinal tract in a mammal which includes administering to the mammal a therapeutically effective amount of Platelet-Derived Growth Factor (PDGF) to the gastrointestinal tract of the mammal.

Abstract: The present invention relates to novel 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) ##STR1## wherein R stands for hydrogen or an alkyl group,X stands for an unsubstituted phenyl or benzyl group or for a phenyl or benzyl group substituted with a halogen atom,Y stands for hydrogen or halogen or a trifluoro-methyl groupas well as enantiomers acid addition salts thereof.The invention further extends to pharmaceutical compositions containing said compounds as active ingredient mainly for improving cerebral blood circulation and antihypoxic activity.

Abstract: The invention relates to a method of preventing or treating gastrointestinal ulcer disease and microvascular injury in a mammal comprising administering to said mammal a pyrazole derivative alone or in combination with an ulcerogenic agent. The invention further relates to pharmaceutical compositions comprising a pyrazole derivative in combination with an ulcerogenic therapeutic agent to inhibit or prevent the ulcerogenic effect of that agent.

Abstract: A new animal model for Inflammatory Bowel Disease, including idiopathic ulcerative colitis and Chron's disease, as well as methods for problems such as an animal, is provided. Chronic ulcerative condition is induced by topical administration of a sulfhydryl blocker, such as N-ethylmaleimide or iodoacetamide, to the colon. The new animal model is useful for studying the pathogenesis of chronic ulcerative disease, and prevention and treatment thereof, and for evaluating drugs suspected of being useful in the treatment of same.

Abstract: The invention relates to novel 15-nitro-2.beta.,3.beta.-dihydro- and 15-nitro-2.beta.,3.beta.,6,7-tetrahydrotabersonine derivatives of the formula (I), ##STR1## wherein R.sup.1 stands for hydrogen;R.sup.2 stands for hydrogen or a C.sub.1-6 alkyl group; and the symbolrepresents a single or double bond as well as their salts.The invention further relates to pharmaceutical compositions containing the above compounds as well as a process for the preparation of the above compounds of formula (I) and of the pharmaceutical compositions.The compounds of formula (I) exert a reducing or inhibitory effect on cerebral edema and show antihypoxic properties. Thus, they are useful for the prevention or treatment of brain injuries of various origin induced by hypoxia of the brain.

Abstract: A stereophonic microphone system for improving stereophonic hearing utilizes intensity stereophonic and/or time difference stereophonic pickup methods with the use of replicas of the human head. The microphones are mounted in the replicas of the outer auditory meatus. The replica of the human head is limited to replicas of the pinna with outer auditory meatus. In addition to the known stereophonic recording device used as a position association stage, two replicas of human pinnas are used, with pressure microphones in each opening of the auditory meatus as a shape association stage. The pinna replicas are arranged spaced apart and oriented on the human head or closely next to each other with the same orientation. The pinna replicas are arranged preferably immediately adjacent the arrangement of known directional microphones for the interaural sound recording in the horizontal and median planes.

Abstract: Ganglioside mixtures and/or lipid mixtures e.g. from brain and omentum, are found to be effective to treat peptic ulcers.

Abstract: A device for the stereophonic recording of sound events by means of two microphones arranged with essentially oppositely directed orientation and mounted in replicas of the human head. The microphones are mounted in the replicas of the outer auditory meatus. The replica of the human head is limited to the replicas of the pinnae with the outer auditory meatus. Microphones with unilateral pickup effect are used and are mounted preferably in positions corresponding to the positions of the pinna openings in human heads. The microphones operate in the low-frequency range of up to approximately 1500 Hz as directional microphones and, in the frequency range above approximately 1500 Hz, operate with spectral resolution of the outer ear transmission function. The device according to the present invention provides compatibility of headset reproduction and loudspeaker reproduction.

Abstract: A method of treating gastrointgestinal ulcer disease is provided which involves administration of a proteinase inhibitor or analogue to patients suffering from same. Of particular interest is the use of inhibitors of serine, cysteine, carboxyl, and metallo proteinases.

Abstract: A method of increasing the clearance of particles from the blood stream of a vertebrate, which comprises administering to a vertebrate having a surplus of particles in the blood stream of the vertebrate an amount of a somatostatin analogue sufficient to increase phagocytosis in the vertebrate is disclosed along with a method treating vascular lesions or deterioration of biological membranes comprising the step of administering to a human or other mammal suspected of having one or more vascular lesions or of having deterioration of a biological membrane in the liver of said human or mammal an amount of a somatostatin analogue sufficient to reduce the number or severity of said lesions or to prevent further deterioration or reduce the extent of deterioration of said membrane.

Abstract: A method of increasing the clearance of particles from the blood stream of a vertebrate, which comprises administering to a vertebrate having a surplus of particles in the blood stream of the vertebrate an amount of somatostatin sufficient to increase phagocytosis in the vertebrate, is disclosed.

Abstract: A method treating vascular lesions or deterioration of biological membranes comprising the step of administering to a human or other mammal suspected of having one or more vascular lesions or of having deterioration of a biological membrane in the liver of said human or mammal an amount of somatostatin sufficient to reduce the number or severity of said lesions or to prevent further deterioration or reduce the extent of deterioration of said membrane.

Abstract: A spring leg with load proportional limited damping for use on a vehicle, includes a telescoping shock absorber including a piston and cylinder and a load bearing air suspension connected to a gas pressure system and having the walls surrounding the air space thereof comprising an elastic jacket and two rigid walls fixed to the body and the axle gear of the vehicle wherein the binding units of the shock absorber are partly arranged in the air space of the air suspension. An auxiliary diaphragm has an inner rim fixed to the cylinder of the shock absorber and an outer rim fixed to one of the two rigid walls of the air suspension to define the auxiliary diaphragm as one of the bordering walls, of the air space of the air suspension. A pilot ring limits the outward movement of the cylinder of the telescopic hydraulic shock absorber from the air space of the air suspension and is fixed to the rigid wall bearing the outer rim of the auxiliary diaphragm.