Patents by Inventor Sandra Amaral

Sandra Amaral has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multispecific binding proteins with mutant fab domains
    Patent number: 11965030
    Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: April 23, 2024
    Assignee: SANOFI
    Inventors: Marta Amaral, Christian Beil, Ingo Focken, Gerhard Hessler, Soraya Hoelper, Jennifer Jung, Christian Lange, Wulf-Dirk Leuschner, Ercole Rao, Garima Tiwari, Sandra Weil
  • Methods of modulating angiogenesis and cancer cell proliferation
    Publication number: 20050124618
    Abstract: Methods for regulating angiogenesis by modulating the activity of 20-HETE are disclosed. Further disclosed are methods of inhibiting cancer and tumor cell growth by exposing the cancer and tumor cells to 20-HETE inhibitors.
    Type: Application
    Filed: November 12, 2004
    Publication date: June 9, 2005
    Inventors: Richard Roman, Andrew Greene, Sandra Amaral, Alfonso Scicli, Stephen Brown