Patents by Inventor Sandra Bartoli

Sandra Bartoli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of intermediates of Nebivolol
    Patent number: 10392361
    Abstract: The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl)chromans of formula I. The intermediates thus obtained can be used for the synthesis of Nebivolol.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: August 27, 2019
    Assignee: Menarini International Operations Luxembourg S.A.
    Inventors: Sandra Bartoli, Serena Mannucci, Alessio Griselli, Alessio Stefanini
  • PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL
    Publication number: 20190031636
    Abstract: The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl)chromans of formula I. The intermediates thus obtained can be used for the synthesis of Nebivolol.
    Type: Application
    Filed: January 23, 2017
    Publication date: January 31, 2019
    Inventors: Sandra BARTOLI, Serena MANNUCCI, Alessio GRISELLI, Alessio STEFANINI
  • Process for the preparation of nebivolol
    Patent number: 8785664
    Abstract: The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: July 22, 2014
    Assignee: Menarini International Operations Luxembourg S.A.
    Inventors: Sandra Bartoli, Amalia Cipollone, Daniela Fattori
  • PROCESS FOR THE PREPARATION OF NEBIVOLOL
    Publication number: 20130274486
    Abstract: The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
    Type: Application
    Filed: May 31, 2013
    Publication date: October 17, 2013
    Inventors: Sandra BARTOLI, Amalia Cipollone, Daniela Fattori
  • Process for the preparation of nebivolol
    Patent number: 8487122
    Abstract: The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: July 16, 2013
    Assignee: Menarini International Operations Luxembourg S.A.
    Inventors: Sandra Bartoli, Amalia Cipollone, Daniela Fattori
  • PROCESS FOR THE PREPARATION OF NEBIVOLOL
    Publication number: 20120316351
    Abstract: The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
    Type: Application
    Filed: February 9, 2011
    Publication date: December 13, 2012
    Inventors: Sandra Bartoli, Amalia Cipollone, Daniela Fattori