Abstract: Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that provide enhanced efficacy when used in the treatment of schizophrenia and/or bipolar mania.

Abstract: The present invention provides a method for the treatment of psychiatric patients having or at risk of hepatic impairment comprising administering a therapeutically effective amount of paliperidone, its pharmaceutically acceptable acid addition salts, enantiomeric forms and esters thereof to psychiatric patients in need thereof.

Abstract: The present invention relates to the use of paliperidone, its pharmaceutically acceptable acid addition salts, enantiomeric forms, or esters thereof, for the treatment of substance abuse in a patient in need thereof. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of paliperidone, its pharmaceutically acceptable acid addition salts, enantiomeric forms, or esters thereof, together with a pharmaceutically acceptable carrier, for the treatment of substance abuse in a patient in need thereof. The invention also provides for the use of a pharmaceutical composition as defined above for the treatment of substance abuse in a patient, and for the use of this pharmaceutical composition in the manufacture of a medicament for the treatment of substance abuse in a patient in need thereof.

Abstract: Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that provide enhanced efficacy when used in the treatment of schizophrenia and/or bipolar mania.