Patents by Inventor Sandra C. Tobias

Sandra C. Tobias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Poly(amide) polymers for the delivery of oligonucleotides
    Patent number: 8987377
    Abstract: The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: March 24, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Stephanie E. Barrett, Marina Busuek, Steven L. Colletti, Robert M. Garbaccio, Erin N. Guidry, Robert A. Kowtoniuk, Jing Liao, Craig A. Parish, Rubina G. Parmar, Tao Pei, Kevin M. Schlosser, David M. Tellers, Sandra C. Tobias, Quang T. Truong, Jacob H. Waldman, Weimin Wang, J. Michael Williams
  • POLY(AMIDE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES
    Publication number: 20130253135
    Abstract: The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Application
    Filed: November 16, 2011
    Publication date: September 26, 2013
    Inventors: Stephanie E. Barrett, Marina Busuek, Steven L. Colletti, Robert M. Garbaccio, Erin N. Guidry, Robert A. Kowtoniuk, Jing Liao, Craig A. Parish, Rubina G. Parmar, Tao Pei, Kevin M. Schlosser, David M. Tellers, Sandra C. Tobias, Quang T. Truong, Jacob H. Waldman, Weimin Wang, J. Michael Williams
  • Phosphoramidates and methods therefor
    Patent number: 7173020
    Abstract: Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable enhanced intracellular delivery of drugs as their corresponding phosphate esters or amides. Described phosphoramidate compounds exhibit antiproliferative activity. Pharmaceutical formulations are provided for treatment of cancers.
    Type: Grant
    Filed: February 8, 2005
    Date of Patent: February 6, 2007
    Assignee: Purdue Research Foundation
    Inventors: Richard F. Borch, Hugo Garrido-Hernandez, Sandra C. Tobias
  • Phosphoramidates and methods therefor
    Patent number: 6903081
    Abstract: Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable enhanced intracellular delivery of drugs as their corresponding phosphate esters or amides. Described phosphoramidate compounds exhibit antiproliferative activity. Pharmaceutical formulations are provided for treatment of cancers.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: June 7, 2005
    Assignee: Purdue Research Foundation
    Inventors: Richard F. Borch, Hugo Garrido-Hernandez, Sandra C. Tobias
  • Phosphoramidates and methods therefor
    Publication number: 20020004594
    Abstract: Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable enhanced intracellular delivery of drugs as their corresponding phosphate esters or amides. Described phosphoramidate compounds exhibit antiproliferative activity. Pharmaceutical formulations are provided for treatment of cancers.
    Type: Application
    Filed: March 30, 2001
    Publication date: January 10, 2002
    Inventors: Richard F. Borch, Hugo Garrido-Hernandez, Sandra C. Tobias