Patents by Inventor Sandra Chaplan

Sandra Chaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying modulators of NAion channels
    Patent number: 7195879
    Abstract: The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Nav expression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Nav1.3 and/or Nav1.7.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: March 27, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Adrienne Dubin, Sandra Chaplan, Sean Brown, Edward Kaftan
  • Combination of tramadol and substances that comprise gabapentin
    Publication number: 20060257484
    Abstract: Disclosed are substances, compositions, dosage forms and methods that comprise tramadol and substances that comprise gabapentin.
    Type: Application
    Filed: April 13, 2006
    Publication date: November 16, 2006
    Inventors: Stephen Hwang, Sandra Chaplan, Dong Yan, Patrick Wong, David Abraham
  • Assay systems and methods for detecting molecules that interact with SK2 channels
    Publication number: 20050250090
    Abstract: The invention provides methods including steps of: providing cells capable of expressing SK2; contacting the cells with a test molecule; obtaining information indicative of cellular SK2 expression to obtain an SK2 Expression Value; comparing the SK2 Expression Value with a control SK2 Expression Value; and identifying a test molecule that causes the cells to display an SK2 Expression Value that is different from the control SK2 Expression Value. Also provided are methods including steps of: providing a sample comprising an SK2 channel; contacting the sample with a test molecule; obtaining information indicative of SK2 channel activity in the sample to obtain an SK2 Channel Activity Value; comparing the SK2 Channel Activity Value with a control Channel Activity Value; and identifying a test molecule that causes the SK2 Channel Activity Value to be different from the control Channel Activity Value. Methods of identifying a molecule useful for treating neuropathic pain are also described.
    Type: Application
    Filed: October 28, 2004
    Publication date: November 10, 2005
    Inventors: Edward Kaftan, Adrienne Dubin, Sandra Chaplan
  • Method for identifying modulators of ion channels
    Publication number: 20030194751
    Abstract: The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Nav expression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Nav1.3 and/or Nav1.7.
    Type: Application
    Filed: April 12, 2002
    Publication date: October 16, 2003
    Inventors: Adrienne Dubin, Sandra Chaplan, Sean Brown, Edward Kaftan
  • Treating pain by targeting hyperpolarization-activated, cyclic nucleotide-gated channels
    Publication number: 20030022813
    Abstract: Markedly enhanced activity of pacemaker (hyperpolarization-activated, cation-nonselective, HCN) ion channels governs spontaneous firing in sensory cells of allodynic rats. An HCN ion channel specific blocker, ZD7288, dose-dependently and completely suppresses allodynia. Nerve injury increases the population of large DRG neurons expressing a high density of Ih and modulates HCN mRNA expression. New methods of treating pain by targeting HCN pacemaker channels are developed. In addition, new methods for identifying compositions useful for treating pain are disclosed.
    Type: Application
    Filed: May 30, 2002
    Publication date: January 30, 2003
    Inventors: Sandra Chaplan, Adrienne Dubin, Hong-Qing Guo, Doo Hyun Lee, Changlu Liu, Lin Luo, Sean Brown
  • Treating pain by targeting hyperpolarization-activated, cyclic nucleotide-gated channels
    Publication number: 20030022812
    Abstract: Markedly enhanced activity of pacemaker (hyperpolarization-activated, cation-nonselective, HCN) ion channels governs spontaneous firing in sensory cells of allodynic rats. An HCN ion channel specific blocker, ZD7288, dose-dependently and completely suppresses allodynia. Nerve injury increases the population of large DRG neurons expressing a high density of Ih and modulates HCN mRNA expression. New methods of treating pain by targeting HCN pacemaker channels are developed. In addition, new methods for identifying compositions useful for treating pain are disclosed.
    Type: Application
    Filed: May 30, 2002
    Publication date: January 30, 2003
    Inventors: Sandra Chaplan, Adrienne Dubin, Doo Hyun Lee, Changlu Liu